Results 211 to 220 of about 1,864,302 (297)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A second generation of C3 humanized rats for preclinical evaluation of human C3 inhibitors. [PDF]

Blood Vessel Thromb Hemost
Chen JY, Yang M, Parab S, Zhang H, Freeman ZT, Saunders TL, Lin F.   +6 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Development of an anti-rat complement C2 antibody that improves renal outcome in a rat kidney transplant model. [PDF]

Front Immunol
Bracke L, Delaere J, Haspeslagh E, De Winter K, Driege Y, Bilgraer R, Delahaye T, Hack CE, Van de Walle I.   +8 more
europepmc   +1 more source

Three-dimensional structure of the rat intestinal wall (Mucosa and submucosa).

, 1990
Terumasa Komuro, Yoshie Hashimoto
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Correction to "Presynaptic Glycine Receptors Increase Glutamatergic Neurotransmission in Rat Periaqueductal Gray Neurons". [PDF]

Neural Plast
europepmc   +1 more source

Prediction of tumour hypoxia status from the washout of positron emitters in beam-monitoring PET: carbon-ion irradiation to tumour rat models. [PDF]

EJNMMI Res
Toramatsu C, Wakizaka H, Tashima H, Sudo H, Akamatsu G, Ishikawa T, Kang HG, Seki C, Kanno I, Yamaya T.   +9 more
europepmc   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models. [PDF]

Signal Transduct Target Ther
Xiong K, Wang G, Li D, Shao B, Chen Z, Zou Q, Zhang X, Dong Y, Zhao X, Yuan Y, Xu H, Liu Y, Liang D, Wang L, Zhou B, Dong N, Xie D, Chen YH.   +17 more
europepmc   +1 more source