Results 61 to 70 of about 1,841,501 (298)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Sleep Deprivation in the Rat: III. Total Sleep Deprivation [PDF]

, 1989
Carol A. Everson, Bernard M. Bergmann, Allan Rechtschaffen   +2 more
openalex   +1 more source

Rat Coronavirus Infection, Lung, Rat [PDF]

, 1985
Naturally infected adult rats rarely have grossly observable changes. Experimentally infected 9–10 week old axenic rats develop gross lesions in the lung on postinoculation days 6 and 7, which consist of randomly dispersed red-brown to gray foci, less than 1 mm in diameter (Bhatt and Jacoby 1977). Although rat coronavirus may cause fatal pneumonia in a
openaire   +2 more sources

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Comparative Analysis of Reinforcement Learning Algorithms for Bipedal Robot Locomotion

IEEE Access
In this research, an optimization methodology was introduced for improving bipedal robot locomotion controlled by reinforcement learning (RL) algorithms.
Omur Aydogmus, Musa Yilmaz
doaj   +1 more source

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity [PDF]

, 2010
Alice L. Rodriguez, Mark D. Grier, Carrie K. Jones, Elizabeth J. Herman, Alexander S. Kane, Randy L. Smith, Richard D. Williams, Ya Zhou, Joy E. Marlo, Emily Days, Tasha N. Blatt, Satyawan Jadhav, Usha N. Menon, Paige N. Vinson, Jerri M. Rook, Shaun R. Stauffer, Colleen M. Niswender, Craig W. Lindsley, C. David Weaver, P. Jeffrey Conn   +19 more
openalex   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Mapping Deprivation in Rural Areas from Transylvania: Reflections on a Methodological Exercise

Studia Universitatis Babes-Bolyai Sociologia, 2015
The aim of the present paper is to present and critically discuss the potentialities and limits of using official data (collected and reported by state-institutions) in order to shed light on consequences of uneven development and measure area ...
Raţ Cristina, Tobias Andrada, Veres Valér   +2 more
doaj   +1 more source

Indication of circadian oscillations in the rat pancreas [PDF]

, 2004
Eckhard Mühlbauer, Sabine Wolgast, Ulrich Finckh, D. Peschke, Elmar Peschke   +4 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source