Results 61 to 70 of about 5,213,242 (382)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody [PDF]

, 1989
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized,
A. Pascualone, A.L. Hoffman, B.F. Banner, Barclay A, Berenson R J, Beschorner W E, Bril H, D.G. Sheahan, D.V. Cramer, Dallman M J, Elkins W L, Farnsworth A, Filipovich A H, Kvalheim G, L. Makowka, Lubaroff D M, Martin P J, Monchik G J, Oaks M K, P. Rettinger, Prentice H G, Reisner Y, Rodt H, Slavin R E, T.E. Starzl, Thtschka P J, Tsoi M-S, Van Bekkum D W, Vartdal F, Waldman H, X. Cai   +30 more
core   +1 more source

“Eek! A Rat!” [PDF]

, 2021
AbstractRats are often despised. In what way does such aversion affect moral deliberation, and if so, how should we accommodate any distorting effects on our normative judgements? These questions are explored in this chapter with regard to recent proposals in (1) the ethics of pest management and (2) animal political theory.
Franck L. B. Meijboom, Joachim Nieuwland
openaire   +3 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

An Efficient Satellite Images Classification Approach Based on Fuzzy Cognitive Map Integration With Deep Learning Models Using Improved Loss Function

IEEE Access
Classification applications in order to obtain the desired information from satellite images are one of the increasing areas of study. Remote sensing satellite images are very difficult to obtain, but nevertheless, they can be used in many different ...
Ebru Karakose
doaj   +1 more source

“Ferocity of Rats” [PDF]

Nature, 1886
IN reference to the correspondence that appeared in last week's issue (p. 513) upon the above subject, permit me to state I have found by practical experience that the ferocity and voracity of rats is very great. They devour one another at all times and under all circumstances, whether living in a wild state or under the influence of domestication.
openaire   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Controlling composition factors of a finite group by its character degree ratio [PDF]

, 2013
For a finite nonabelian group $G$ let $\rat(G)$ be the largest ratio of degrees of two nonlinear irreducible characters of $G$. We show that nonabelian composition factors of $G$ are controlled by $\rat(G)$ in some sense.
Hung, James P. Cossey, Ngoc Nguyen
core  

Pathfinder cells provide a novel therapeutic intervention for acute kidney injury [PDF]

, 2013
Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they enable the functional mitigation of ischemia reperfusion (I/R) injury in a mouse model of renal ...
Alan MacIntyre, Alasdair I. MacDonald, Christian Koppelstaetter, David Russell, Herrera MB, Iwatani H, Kathrin Eller, Liane M. McGlynn, Megyesi J, Paul G. Shiels, R.W. Davies, Thakar CV   +11 more
core   +1 more source