Results 101 to 110 of about 2,841,411 (301)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Effects of a 7-day step taper, training cessation, and retraining on lower body physical and morphological aspects in elite female ice hockey players

Frontiers in Sports and Active Living
PurposeThis study investigated the effects of a 7-day step taper before a national championship, followed by 2 weeks of training cessation and 2 weeks of retraining on lower body physical and morphological aspects.MethodsSeven elite female ice hockey ...
Daichi Nishiumi, Daichi Yamashita, Takanori Kurokawa, Naoki Hirase, Kazuki Wakamiya, Iñigo Mujika, Iñigo Mujika, Norikazu Hirose   +7 more
doaj   +1 more source

DEMOGRAPHIC AND LABOUR FORCE AGEING – RISK FACTORS FOR THE SOCIAL PROTECTION SYSTEM IN ROMANIA [PDF]

Population ageing is one of the main challenges to the economic and social development in the next decades. This article examines the main implications of demographic and labour force ageing on the future of social protection in Romania.
Maria POENARU
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

ON-THE-JOB SEARCH, URBAN INFORMAL SECTOR AND THE DEVELOPMENT POLICIES-A GENERAL EQUILIBRIUM ANALYSIS [PDF]

The purpose of this paper is to examine the Fields (1989) proposition1 in a multi sector general equilibrium model with perfect and imperfect capital mobility2.
Titas Bandopadhyay
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development of a mechanism for adjusting force distribution rate in force sensors to implement variable admittance control

Nihon Kikai Gakkai ronbunshu
A novel force distribution adjustment mechanism for force sensors is proposed to implement variable admittance control in robotic systems. While admittance control is widely utilized in physical human–robot interactions (pHRI), existing approaches face ...
Shujiro SUGIYAMA, Toru TSUMUGIWA, Ryuichi YOKOGAWA   +2 more
doaj   +1 more source

China's Economic Growth and its Real Exchange Rate [PDF]

The recent influx of financial capital to China implies expectations of continued real appreciation and, indeed, rapid expansion had previously led to real appreciations elsewhere in East Asia. In a world of open economies and differentiated traded goods,
Bu Yongxiang, Ian Bain, Jane Golley, Rod Tyers   +3 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source