Results 71 to 80 of about 2,841,411 (301)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Isometric Mid-Thigh Pull Performance in Rugby Players: A Systematic Literature Review

Journal of Functional Morphology and Kinesiology, 2020
The isometric mid-thigh pull (IMTP) is a multi-joint test of whole-body force production relevant to rugby players. “Rugby AND (mid-thigh pull OR midthigh pull OR mid thigh pull” were searched in PubMed, Sportdiscus, Academic Search Premier, CINAHL Plus ...
Eric A. Martin, George K. Beckham
doaj   +1 more source

Weekly Versus Monthly Testosterone Administration On Fast and Slow Skeletal Muscle Fibers in Older Adult Males [PDF]

, 2014
Context: In older adults, loss of mobility due to sarcopenia is exacerbated in men with low serum T. T replacement therapy is known to increase muscle mass and strength, but the effect of weekly (WK) vs monthly (MO) administration on specific fiber types
Dillon, E. Lichar, Durham, William J., Fitts, Robert, Peters, James R., Sheffield-Moore, Melinda, Urban, Randall J.   +5 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Symposium on Labour Force Participation in Canada in the 1990s: An Introduction and Overview [PDF]

A major development in the Canadian labour market in the 1990s has been the decline in labour force participation. This issue of Canadian Business Economics consists of a symposium of articles that explore this issue. The idea for this symposium came out
Andrew Sharpe, Andrew Sharpe, Louis Grignon, Louis Grignon   +3 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Economic Development and Female Labor Force Participation in Turkey: Time-Series Evidence and Cross-Province Estimates [PDF]

Recently, several researchers hypothesized that female labor force participation rate exhibits a U-shape during the process of economic development.
Aysit Tansel
core  

Kinetic Quantification of Plyometric Take Off, Flight, and Landing Characteristics [PDF]

, 2010
This study assessed the kinetic characteristics of a variety of plyometric exercises and assessed gender differences therein. Twenty-six men and 23 women performed a variety of plyometric exercises including line hops, 15.24 cm cone hops, squat jumps ...
Ebben, William, Feldmann, Christina, Garceau, Luke, Petushek, Erich, VanderZanden, Tyler, Wurm, Brad   +5 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Faster movement speed results in greater tendon strain during the loaded squat exercise

Frontiers in Physiology, 2016
Introduction: Tendon dynamics influence movement performance and provides the stimulus for long-term tendon adaptation. As tendon strain increases with load magnitude and decreases with loading rate, changes in movement speed during exercise should ...
Jacob Edward Earp, Jacob Edward Earp, Robert U Newton, Prue Cormie, Prue Cormie, Anthony John Blazevich   +5 more
doaj   +1 more source