Results 111 to 120 of about 60,078 (296)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Do Credit Rating Agencies Add to the Dynamics of Emerging Market Crises? [PDF]
The experience in the period during and after the Asian crisis of 1997-98 has provoked an extensive debate about the credit rating agencies’ evaluation of sovereign risk in emerging markets lending.
Roman Kraeussl
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Rating Assignments: Lessons from International Banks [PDF]
This paper estimates ordered logit and probit regression models for bank ratings which also include a country index to capture country-specific variation.
Guglielmo Maria Caporale +2 more
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The Reform of the Credit Rating Agencies: A Comparative Perspective. ECMI Policy Brief No. 12, February 2009 [PDF]
, 2009 Credit ratings are a quasi-public good, and investors and financial markets regulators need an independent assessment of the credit-worthiness of an issuing entity because of information asymmetries and principal agent problems.
Cinquegrana, Piero.
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Corporate ESG performance, digital transformation and climate risk disclosure
Sustainable FuturesThis paper uses the data of all listed companies in China's A-share market from 2010 to 2022, and employs textual analysis to construct climate risk disclosure indicators using corporate annual reports to validate the relationship between ESG ratings and
Yufei Yan, Changhao Gong, Hua Zhang
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Rating de crédito no Brasil: fatores determinantes e impacto de anúncios nos preços das ações [PDF]
, 2013 Tese (doutorado] - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em Administração, Florianópolis, 2013.O presente estudo teve como objetivo analisar o rating de crédito de companhias abertas no Brasil, com ...
Murcia, Flávia Cruz de Souza
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source