Results 31 to 40 of about 19,451 (267)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Advances in Mathematics, 1978 Let \(\pi_m\) denote the class of all real polynomials of degree at most \(m\) and \(\pi_{m,n}\) denote the collection of all rational functions \(r_{m,n}(x)=\frac{p(x)}{q(x)}, p\in\pi_m, q\in\pi_n\). Let \(\lambda_{m,n}\equiv\lambda_{m,n}(f^{-1})=\inf_{r_{m,n}\in\pi_{m,n}}\left\|\frac1{f(x)}-\gamma_{m,n}(x)\right\|_{l_{\infty}[0,\infty]}\) where \(f\),
Erdös, Paul +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Operational characteristic and approximation performance analysis of Oustaloup fractance circuits
四川大学学报. 自然科学版, 2016 In this paper, we investigated operational characteristics and approximation performance of Oustaloup fractance rational approximation from a new perspective of fractional calculus operation.
LIU Pan-Pan, YUAN Xiao, TAO Lei, YI Zhou
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A Note on Rational Approximation [PDF]
Mathematics of Computation, 1960 p(x) = qo(x) * Tn +1 (x) + ro(x) YTn~l(x =-q1(x)W ro(x) + r1(x) ro(x) = q2-(X) * ri(x) + r2(x) r1() = q3(x) *r2(x) + r3(X), etc., where the (degrees of thie ri formr a strictly decreasing sequence. From these equations we may write r,(Q) = i(x) -.p(.x) + bi(x) . T.+1(x), where ai and bi are defined recursively by (a,=ai-. -qiai-?, a-1=O, a2= 1 lbi = bi-
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Approximation performance analysis of Oustaloup rational approximation of ideal fractance
工程科学与技术, 2016 :Starting from operational characteristics, in this paper, the operational characteristics localization of zero-pole subsystem of Oustaloup was analyzed based on order-frequency and phase-frequency characteristic function.
Liu Panpan, Yuan Xiao
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