Advanced Healthcare Materials, EarlyView.Wound closure is governed by geometry‐orientation coupling: aligned fibers speed migration along their axis but hinder perpendicular advance. In vivo diabetic wound experiments with composition‐matched fibrin, combined with an anisotropic diffusion (biased random‐walk) model, quantify this trade‐off and generate a healing landscape.
Yin‐Yuan Huang +13 more
wiley +1 more source
Metabolic Bone Disease in Coeliac Disease: Protecting Bone, Resources, or Both? [PDF]
United European Gastroenterol JTovoli F, Granito A, Zavatta G.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise +4 more
wiley +1 more source
Editorial: Design and bioapplication of nanozymes. [PDF]
Front ChemCheng Y, Huang C, Zhang Z.
europepmc +1 more source
CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads
Advanced Healthcare Materials, EarlyView.In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura +4 more
wiley +1 more source
Soliton dynamics of the fourth-order nonlinear Boussinesq equation arising in shallow-water via advanced analytical techniques. [PDF]
Sci RepMalik S +3 more
europepmc +1 more source
Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
Advanced Healthcare Materials, EarlyView.A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Construction of complex non-uniform rational B-spline volume parametric models with G<sup>1</sup> continuity. [PDF]
Vis Comput Ind Biomed ArtWang D, Chen L, Zhang J.
europepmc +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Azure A Dye Interaction with Double-Stranded DNA Can Be Modulated by the Ionic Strength: Choosing the Binding Mode. [PDF]
ACS Omegade Rezende AGS +3 more
europepmc +1 more source