Results 91 to 100 of about 11,489,693 (332)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Central Point Notice of Adopted Amendment (2008-12-29) [PDF]
, 2008 162 pp. Adopted 2008-12-29. Department of Land Conservation and Development Notice of Adopted AmendmentThe attached proposed amendment is the Central Point Transportation System Plan (TSP) which will be an element of the updated Central Point ...
Central Point (Or.)
core
Fractal Behavior of a Ternary 4-Point Rational Interpolation Subdivision Scheme
Mathematical and Computational Applications, 2018 In this paper, a ternary 4-point rational interpolation subdivision scheme is presented, and the necessary and sufficient conditions of the continuity are analyzed.
Kaijun Peng +3 more
doaj +1 more source
ON THE RATIONAL POINTS ON CUBIC SURFACES [PDF]
Glasgow Mathematical Journal, 2000 Let \(N(P)\) denote the number of solutions in integers \(x_i\) with \(|x_i|\leq P\) of \(\sum_{1 \leq i \leq 4}a_ix_i^3 = 0\), in which \(a_i \neq 0\), and let \(N_1(P)\) denote the number of these solutions that do not lie on rational lines in the projective surface \(\mathcal S\) defined by this equation. \textit{D. R. Heath-Brown} [Philos. Trans. R.
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Cuspidal representations of rational Cherednik algebras at t=0 [PDF]
, 2010 We study those finite dimensional quotients of the rational Cherednik algebra at t=0 that are supported at a point of the centre. It is shown that each such quotient is Morita equivalent to a certain cuspidal quotient of a rational Cherednik algebra ...
Bellamy, G., Gwyn Bellamy
core +1 more source
Common fixed point theorems under rational contractions in complex valued metric spaces
, 2015 In this paper, we prove some common fixed point theorems for a pair of mappings satisfying certain rational contractions in the frame work of complex valued metric besides discussing consequences of our main results.
H. Nashine, M. Imdad, M. Hasan
semanticscholar +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Fixed point results in ordered metric spaces for rational type expressions with auxiliary functions
, 2015 In this paper, we establish some fixed point results for mappings involving ( ϕ , ψ ) -rational type contractions in the framework of metric spaces endowed with a partial order.
S. Chandok, B. Choudhury, N. Metiya
semanticscholar +1 more source