Results 251 to 260 of about 30,459 (317)

Natural Products Targeting PAD4 in NETosis: Structural and Mechanistic Insights into Direct and Indirect Inhibition. [PDF]

Biomolecules
Moon DO.
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Data-Driven Exploration of Critical Factors for Single-Phase High-Entropy Oxide Anode Materials. [PDF]

J Phys Chem Lett
Kanno M, Taniike T, Honma I.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Adaptive lattice breathing enabled by Cu/Mg co-doping for stable anionic redox chemistry in sodium layered oxides. [PDF]

Chem Sci
Zhang Z, Yin W, Peng J, Zheng F, Pan Q, Wang H, Li Q, Hu S.   +7 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

The Thermodynamic and Gelation Properties of Ovalbumin and Lysozyme. [PDF]

Gels
Wang L, Li R, Lv S, Liu Y, Fang S, Zang J, Qing M, Chi Y.   +7 more
europepmc   +1 more source

Oxygen-Vacancy-Rich V₂O₅@NC Composite with Enhanced Zinc-Storage Performance for Aqueous Zinc-Ion Batteries. [PDF]

Materials (Basel)
Zhou T, Liang P, Li S, Cheng Y, Li X.
europepmc   +1 more source

Epigenetic and transcriptional control of classical and basal-like cell states in pancreatic ductal adenocarcinoma. [PDF]

Gastroenterol Rep (Oxf)
Parassiadis C, Johnsen SA.
europepmc   +1 more source