Results 51 to 60 of about 709,545 (374)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The evolution of online news headlines
Humanities & Social Sciences CommunicationsAs the written word has moved online, new technological affordances and pressures – such as accelerated cycles of production and consumption – have changed how news headlines are produced and selected. Previous literature has linked certain strategies (e.
Pietro Nickl +2 more
doaj +1 more source
Are rational expectations really rational? [PDF]
Economics Letters, 1992 Abstract This article investigates whether ‘rational expectations’ are really rational, i.e. whether they maximize agents' utilities in some way. For that purpose we construct a model where each agent may have a whole array of expectations schemes, including the rational expectations one.
openaire +3 more sources
Rationalizing rational expectations: Characterizations and tests
Quantitative Economics, 2021 In this paper, we build a new test of rational expectations based on the marginal distributions of realizations and subjective beliefs. This test is widely applicable, including in the common situation where realizations and beliefs are observed in two different data sets that cannot be matched.
Xavier D'Haultfoeuille +3 more
openaire +9 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Complementarity and Scientific Rationality [PDF]
, 2004 Bohr's interpretation of quantum mechanics has been criticized as incoherent and opportunistic, and based on doubtful philosophical premises. If so Bohr's influence, in the pre-war period of 1927-1939, is the harder to explain, and the acceptance of his ...
A. Einstein +25 more
core +4 more sources
On the rationality of Case [PDF]
Language Sciences, 2014 Case marking has long resisted rationalization in terms of language-external systems of cognition, representing a classical illustration in the generative tradition for an apparently purely 'formal' or 'syntactic' aspect of grammatical organization. I argue that this impasse derives from the prevailing absence of a notion of grammatical meaning, i.e ...
openaire +4 more sources
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source
The institutional context of rationality [PDF]
, 2017 In the last three decades, mainstream economics has been influenced by authors associated with new institutional economics and new behavioral economics.
Godłów-Legiędź, Janina
core +1 more source
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source