Results 81 to 90 of about 1,523,647 (396)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Adaptive mechanisms of social and asocial learning in immersive collective foraging
Nature CommunicationsHuman cognition is distinguished by our ability to adapt to different environments and circumstances. Yet the mechanisms driving adaptive behavior have predominantly been studied in separate asocial and social contexts, with an integrated framework ...
Charley M. Wu +5 more
doaj +1 more source
Mind, rationality, and cognition: An interdisciplinary debate
Psychonomic Bulletin & Review, 2017 This paper features an interdisciplinary debate and dialogue about the nature of mind, perception, and rationality. Scholars from a range of disciplines — cognitive science, applied and experimental psychology, behavioral economics, biology and ...
N. Chater +11 more
semanticscholar +1 more source
Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength [PDF]
, 2021 Eric R. Samuels, Irina F. Sevrioukova
openalex +1 more source
Litigation and new technologies in post-conventional societies [PDF]
, 2012 The increase in the volume of litigation verified since the 1990’s, having the Brazilian society as context, made the judiciary open itself to new technologies which facilitate the access to justice, as well as to a faster resolution of the demands ...
Bannwart Junior, Clodomiro José +1 more
core
It’s time for rational rationing [PDF]
British Journal of General Practice, 2013 > ‘Ask me my three main priorities for the NHS, and I tell you: efficiency, efficiency, efficiency.’ No government minister said this, at least not yet. Of course, the government wants quality too, but its war is on spending, and efficiency is its weapon. NHS spending power is set to remain stable at best for the foreseeable future.
openaire +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Social Influence in Adolescent Decision-Making: A Formal Framework
Frontiers in Psychology, 2019 Adolescence is a period of life during which peers play a pivotal role in decision-making. The narrative of social influence during adolescence often revolves around risky and maladaptive decisions, like driving under the influence, and using illegal ...
Simon Ciranka +4 more
doaj +1 more source