Platelet-activating factor and hyperacute rejection: The effect of a platelet-activating factor antagonist, sri 63-441, on rejection of xenografts and allografts in sensitized hosts [PDF]
, 1990 The pathogenesis of hyperacute transplantation reactions includes the activation of a cascade of nonspecific inflammatory reactions that precipitates the destruction of the target organ.
Chapman, FA +5 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic +9 more
wiley +1 more source
Induction of donor-specific transplantation tolerance to skin and cardiac allografts using mixed chimerism in (A + B → A) in rats [PDF]
, 1993 Mixed allogeneic chimerism (A + B → A) was induced in rats by reconstitution of lethally irradiated LEW recipients with a mixture of T-cell depleted (TCD) syngeneic and TCD allogeneic ACI bone marrow. Thirty-seven percent of animals repopulated as stable
Cai, X +4 more
core +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.In this paper, we describe a common recurrent founder variant in the BRCA gene that was observed in the native Qatari population among high‐risk individuals seen in the cancer genetic clinic at the National Center for Cancer Care and Research. BRCA gene is associated with Hereditary breast and ovarian cancer syndrome (HBOC); it is very common in Qatar ...
Salha Bujassoum Al‐Bader +9 more
wiley +1 more source
The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation:relevance to autosomal dominant hypocalcemia type 1 (ADH1) [PDF]
, 2015 Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum parathyroid hormone (PTH) concentrations and ...
Allen M. Spiegel +44 more
core +1 more source
Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging
Aging Cell, Volume 25, Issue 1, January 2026.A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi +17 more
wiley +1 more source
Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]
, 2014 The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt +18 more
core +1 more source
Mortality and Neurodevelopmental Outcome in an Italian Cohort of Very Low Birth Weight Infants
Acta Paediatrica, Volume 115, Issue 1, Page 153-165, January 2026.ABSTRACT Aim Preterm infants face high risks of mortality and neurodevelopmental impairment. We aimed to evaluate the outcomes in an Italian cohort of very low birth weight infants. Methods This multicenter prospective study included very low birth weight infants born in Italy between 2016 and 2020. Severe functional disability was defined as cognitive
Licia Lugli +28 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Real‐World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors
Acta Paediatrica, Volume 114, Issue 11, Page 2874-2884, November 2025.ABSTRACT Aim This study assessed neurodevelopmental outcomes in neonates with hypoxic‐ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) outside randomised controlled trials (RCTs). It also aimed to identify predictors of outcomes and evaluate TH practices across centres.
Luca Bedetti +23 more
wiley +1 more source