Results 41 to 50 of about 6,402 (133)

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation:relevance to autosomal dominant hypocalcemia type 1 (ADH1) [PDF]

, 2015
Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum parathyroid hormone (PTH) concentrations and ...
Allen M. Spiegel, Breitwieser, Dong, Drude, Enikö Kallay, Fadil M. Hannan, Gerard V. Walls, Gowen, Hannan, Hannan, Harding, Hofer, Hough, Hu, Hu, Huang, Jianxin Hu, John, Kinoshita, Kumar, Leach, Leach, Letz, Letz, Lia-Baldini, Loupy, M. Andrew Nesbit, Miedlich, Nemeth, Nemeth, Nesbit, Pearce, Pearce, Petrel, Rajesh V. Thakker, Raue, Roger D. Cox, Stechman, Tertius A. Hough, Thim, Valerie N. Babinsky, Vargas-Poussou, Watanabe, William D. Fraser, Yamamoto   +44 more
core   +1 more source

Development of a cost‐effective high‐throughput mid‐density 5K genotyping assay for germplasm characterization and breeding in groundnut

The Plant Genome, Volume 18, Issue 2, June 2025.
Abstract Groundnut (Arachis hypogaea L.), also known as peanut, is an allotetraploid legume crop composed of two different progenitor sub‐genomes. This crop is an important source for food, feed, and confectioneries. Leveraging translational genomics research has expedited the precision and speed in making selections of progenies in several crops ...
Manish K. Pandey, Vinay Sharma, Aamir W. Khan, Pushpesh Joshi, Sunil S. Gangurde, Prasad Bajaj, Pasupuleti Janila, Annapurna Chitikineni, Ramesh Bhat, Babu N. Motagi, Chandramohan Sangh, Thankappan Radhakrishnan, Sandip K. Bera, Gregor Gorjanc, Krishna Reddy Gujjula, Nathan Hall, Claudio D. Carrasco, Kandalam Arjun, Srinivas Chandram, Rajeev K. Varshney   +19 more
wiley   +1 more source

Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation [PDF]

, 2008
The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance.
Akdis, Benichou, Buiting, Cebon, Csencsits, Dai, Demetris, Demetris, Demetris, Fleisch, Ganta, Gould, Heeger, Huitinga, Ichikawa, Josien, Jurcevic, Ko, Konieczny, Lakkis, Larsen, Lechler, Mellor, Munn, Murase, Murase, Murase, Nakao, Neto, Nikolic, Okuda, Rabinovich, Raisanen-Sokolowski, Sawitzki, Sekine, Sims, Slegers, Smith, Starzl, Starzl, Sun, Talmage, Van Rooijen, Van Rooijen, Van Rooijen, Wu, Yagihashi, Yan, Zhang   +48 more
core   +2 more sources

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Applying refinement to the use of mice and rats in rheumatoid arthritis research [PDF]

, 2015
Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo
A Dinda, A Julià, A Livingston, AL Whittaker, AM Pulichino, B Bolon, BN Gaskill, BN Gaskill, C Kilkenny, C Kilkenny, CA Christianson, CL Karp, CM Sherwin, D Baker, D Pretzel, D Volker, DB Bas, DD Brand, DJ Langford, DS McQueen, E Hutchinson, Elliot Lilley, European Commission, FC Colpaert, FC Colpaert, FC Colpaert, G Kollias, GK Ford, H Smolian, H Yoshitomi, HB Patel, HB Worp van der, HE Krug, J Havey, JL Hurst, JR Earl, K Gouveia, K Ren, Katherine Knight, KM Kokolus, KR Jacobsen, KSP Abelson, L Bevaart, L Carbone, L Moja, LF Mikkelsen, LM Khachigian, M Bara, M Bianchi, M Neidhart, MH Ullman-Culleré, Michael Seed, Michael Wilkinson, MJ Gentle, MJ Molina-Cimadevila, ML Andersen, MW Festing, N Maicas, N Malik, National Research Council, NJ Osborne, P Hawkins, P Honoré, P Loo Van, P McGonigle, Paul Garside, Penny Hawkins, PH Wooley, R McCarthy, Rachel Armstrong, Richard O. Williams, RS Ulrich, S Ribel-Madsen, SA Tischkau, SC Chan, SG Sotocinal, SG Trivedi, SH Richter, T Montero-Melendez, Tania Boden, TL Vincent, V Baumans, V Marashi, V Strand, W Paska, Y Jasemian, Y Peck   +86 more
core   +2 more sources

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

Aging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud   +9 more
wiley   +1 more source

Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]

, 2015
We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Diez, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Mont-Cardona, Carme, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +16 more
core   +1 more source

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies

Exploration, Volume 5, Issue 2, April 2025.
The monkeypox virus (MPXV) has spread to many countries and caused thousands of infections all over the world. This review comprehensively introduces the biology, epidemiological characteristics of MPXV, and clinical manifestations of Mpox. The approaches for diagnosis, treatment, and prevention are also introduced, aiming to improve the general ...
Lin Jiang, Ailan Xu, Lin Guan, Yong Tang, Guangshuai Chai, Junya Feng, Yueqi Wu, Maochen Li, Chuxie Zhang, Xiaojing Liu, Xiaolong Xu, Qingquan Liu, Lihua Song, Yigang Tong, Renald Blundell, Huahao Fan   +15 more
wiley   +1 more source

Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats

Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.
A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King, Apurva S. Chitre, Joel D. Leal‐Gutiérrez, Jordan A. Tripi, Alesa H. Netzley, Aidan P. Horvath, Alexander C. Lamparelli, Anthony George, Connor Martin, Celine L. St. Pierre, Thiago Missfeldt Sanches, Hannah V. Bimschleger, Jianjun Gao, Riyan Cheng, Khai‐Minh Nguyen, Katie L. Holl, Oksana Polesskaya, Keita Ishiwari, Hao Chen, Terry E. Robinson, Shelly B. Flagel, Leah C. Solberg Woods, Abraham A. Palmer, Paul J. Meyer   +23 more
wiley   +1 more source

FK506 suppression of heart and liver allograft rejection: II: The induction of graft acceptance in rats [PDF]

, 1990
Lewis recipients of orthotopic ACI livers had permanent graft acceptance induced with 3 doses of i.m. FK506 in the early postoperative period. They were studied 100 and 300 days posttransplantation.
Cramer, DV, Dong-Goo, K, Fung, J, Murase, N, Starzl, TE, Todo, S   +5 more
core   +1 more source