Results 41 to 50 of about 6,259 (153)

Animal models of benign airway stenosis: Advances in construction techniques, evaluation systems, and perspectives

Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 280-297, February 2026.
Currently, the animals commonly used to establish animal models of benign airway stenosis (BAS) include mice, rats, pigs, dogs, rabbits, and ferrets. The establishment methods involve one or a combination of two methods such as mechanical injury, tracheal cautery, cuff overpressure intubation, laser injury, and endoscopic silver nitrate cauterization ...
Wusheng Zhang, Yilin Chen, Chengcheng Yang, Yuchao Dong, Haidong Huang, Hui Shi, Chong Bai   +6 more
wiley   +1 more source

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]

, 2014
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt, Galione, Antony, He, Hong, Hessner, Martin, Hoffmann, Raymond G., Holl, Katie, Jacob, Howard, Jia, Shuang, Kaldunski, Mary, Li, Shun-Hua, Meigs, James, Parrington, John, Ruas da Silva, Margarida, Simpson, Pippa, Solberg Woods, Leah C., Stoddard, Alex, Tsaih, Shirng-Wern, Tschannen, Michael, Wiederhold, Andrew   +18 more
core   +1 more source

Genome‐Edited Maize Expressing Two Native Genes Confers Broad‐Spectrum Resistance to Northern Corn Leaf Blight

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
We identified a novel resistance allele, NLB18‐R, at the Htn1 locus. Using CRISPR‐Cas9, we replaced the susceptible allele (NLB18‐S) with NLB18‐R in an elite inbred. We stacked NLB18‐R and the resistance gene Ht1‐R. The resulting genome‐edited plants exhibited resistance to Setosphaeria turcica races 0, 1 and 23N.
Huirong Gao, Bailin Li, Kevin Fengler, Meizhu Yang, Megan Schroder, Melissa Rahe, Nathalie Sanyour‐Doyel, Julie Qi, Victor LIaca, Mary Beatty, Wang‐Nan Hu, Brittany Barrett, Bret Norman, Hua Mo, April Leonard, Bill Wilson, Robert B. Meeley, Leandro Perugini, Nandini Krishnamurthy, Jeffrey E. Habben, Girma Tabor   +20 more
wiley   +1 more source

Identifying a Recurrent BRCA1 Variant in the Qatari Population With Unique Genotype—Phenotype Correlations

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
In this paper, we describe a common recurrent founder variant in the BRCA gene that was observed in the native Qatari population among high‐risk individuals seen in the cancer genetic clinic at the National Center for Cancer Care and Research. BRCA gene is associated with Hereditary breast and ovarian cancer syndrome (HBOC); it is very common in Qatar ...
Salha Bujassoum Al‐Bader, Hajer Al‐Mulla, Hind Al‐Habish, Sitti Kusasi, Nema Abduo, Nawal Bakheet, Hafedh Ghazouani, Mariem Sidenna, Fatemeh Abbaszadeh, Reem Alsulaiman   +9 more
wiley   +1 more source

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, Volume 25, Issue 1, January 2026.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Mortality and Neurodevelopmental Outcome in an Italian Cohort of Very Low Birth Weight Infants

Acta Paediatrica, Volume 115, Issue 1, Page 153-165, January 2026.
ABSTRACT Aim Preterm infants face high risks of mortality and neurodevelopmental impairment. We aimed to evaluate the outcomes in an Italian cohort of very low birth weight infants. Methods This multicenter prospective study included very low birth weight infants born in Italy between 2016 and 2020. Severe functional disability was defined as cognitive
Licia Lugli, Luca Bedetti, Marisa Pugliese, Isotta Guidotti, Gina Ancora, Giancarlo Gargano, Serafina Perrone, Agostina Solinas, Mario Motta, Luigi Tommaso Corvaglia, Alessandra Sansavini, Marcello Stella, Riccardo Cuoghi Costantini, Antonella DiCaprio, Elisa Della Casa Muttini, Maria Federica Roversi, Natascia Bertoncelli, Piero Catenazzi, Elisa Ballardini, Sara Grandi, Sabrina Moretti, Daniela Turoli, Arianna Aceti, Silvia Braibanti, Anna Insalaco, Camilla Migliozzi, Monica Fumagalli, Fabrizio Ferrari, Alberto Berardi   +28 more
wiley   +1 more source

Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]

, 2015
Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
core   +1 more source

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing-receptor (CaSR) mutation:relevance to autosomal dominant hypocalcemia type 1 (ADH1) [PDF]

, 2015
Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum parathyroid hormone (PTH) concentrations and ...
Allen M. Spiegel, Breitwieser, Dong, Drude, Enikö Kallay, Fadil M. Hannan, Gerard V. Walls, Gowen, Hannan, Hannan, Harding, Hofer, Hough, Hu, Hu, Huang, Jianxin Hu, John, Kinoshita, Kumar, Leach, Leach, Letz, Letz, Lia-Baldini, Loupy, M. Andrew Nesbit, Miedlich, Nemeth, Nemeth, Nesbit, Pearce, Pearce, Petrel, Rajesh V. Thakker, Raue, Roger D. Cox, Stechman, Tertius A. Hough, Thim, Valerie N. Babinsky, Vargas-Poussou, Watanabe, William D. Fraser, Yamamoto   +44 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Small RNA expression and strain specificity in the rat [PDF]

, 2010
Background Digital gene expression (DGE) profiling has become an established tool to study RNA expression. Here, we provide an in-depth analysis of small RNA DGE profiles from two different rat strains (BN-Lx and SHR) from six different rat tissues ...
Sam EV Linsen, Elzo de Wit, Ewart de Bruijn, Edwin Cuppen   +3 more
core   +1 more source