Results 11 to 20 of about 20,819 (124)
Frontiers in Behavioral Neuroscience, 2022 Genetic background and age at first exposure have been identified as critical variables that contribute to individual vulnerability to drug addiction. Evidence shows that genetic factors may account for 40–70% of the variance in liability to addiction ...
Silvia Corongiu +7 more
doaj +1 more source
Derivation of a germline competent transgenic Fischer 344 embryonic stem cell line. [PDF]
PLoS ONE, 2013 Embryonic stem (ES) cell-based gene manipulation is an effective method for the generation of mutant animal models in mice and rats. Availability of germline-competent ES cell lines from inbred rat strains would allow for creation of new genetically ...
Hongsheng Men, Elizabeth C Bryda
doaj +1 more source
Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study. [PDF]
PLoS ONE, 2018 A majority of patients with orofacial cleft deformity requires cleft repair through a bone graft. However, elevated amount of bone resorption and subsequent bone graft failure remains a significant clinical challenge.
Christine Hong +10 more
doaj +1 more source
Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex [PDF]
Laboratory Animals, 1991 Data on the blood enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were collected from control male and female F344 rats participating in toxicity studies at 17, 30, 56, 80 and 106 weeks of age. The data were skewed to the right with significant deviation from normality.
T, Waner, A, Nyska, R, Chen
openaire +2 more sources
Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats
Journal of Applied Toxicology, Volume 43, Issue 9, Page 1293-1305, September 2023., 2023 Abstract We recently developed a rat whole exome sequencing (WES) panel and used it to evaluate early somatic mutations in archival liver tissues from F344/N rats exposed to the hepatocarcinogen, Aflatoxin B1 (AFB1), a widely studied, potent mutagen and hepatocarcinogen associated with hepatocellular carcinoma (HCC).
Julie F. Foley +10 more
wiley +1 more source
Advanced models for respiratory disease and drug studies
Medicinal Research Reviews, Volume 43, Issue 5, Page 1470-1503, September 2023., 2023 Abstract The global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed recently, along with increased air pollution and wildfire events, increases the urgency of identifying the most effective therapeutic measures to combat these diseases even ...
Jesus Shrestha +8 more
wiley +1 more source
BMC Biotechnology, 2007 Background Immune-mediated rejection of labeled cells is a general problem in transplantation studies using cells labeled with any immunogenic marker, and also in gene therapy protocols.
Sandgren Eric P +4 more
doaj +1 more source
Cell Proliferation, Volume 56, Issue 5, May 2023., 2023 We established a novel inducible haematopoietic cell‐depleting mouse model and tested the feasibility of using chimeric complementation to regenerate HSCs and their progeny cells. Large populations of syngeneic and major histocompatibility‐mismatched haematopoietic cells were successfully regenerated by this model.
Weiyun Cao +7 more
wiley +1 more source
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +1 more source
Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature
Birth Defects Research, Volume 115, Issue 7, Page 687-709, April 15, 2023., 2023 Abstract Background Based on new testing, we re‐assess U.S. EPA and California OEHHA conclusions regarding male reproductive toxicity associated with cyanide exposure. Methods Literature identified by ATSDR, ECETOC and EPA was complemented by studies conducted after 2006. Relevant studies were scored for quality using ToxRTool. Results Eleven pertinent
Amy Lavin Williams, John M. DeSesso
wiley +1 more source