Results 11 to 20 of about 6,967 (96)

Updated Neuronal Numbers of the Rat Hippocampal Formation: Redesigning the Hippocampal Model. [PDF]

Hippocampus
ABSTRACT The hippocampal formation is a functional entity that includes the hippocampus, subicular complex, and the entorhinal cortex, and has an essential role in learning and memory, emotional processing, and spatial coding. The well‐defined structure of hippocampal fields and the segregation of the connections have made this structure a favorite ...
Arellano JI, Rakic P.
europepmc   +2 more sources

Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats

Journal of Applied Toxicology, Volume 43, Issue 9, Page 1293-1305, September 2023., 2023
Abstract We recently developed a rat whole exome sequencing (WES) panel and used it to evaluate early somatic mutations in archival liver tissues from F344/N rats exposed to the hepatocarcinogen, Aflatoxin B1 (AFB1), a widely studied, potent mutagen and hepatocarcinogen associated with hepatocellular carcinoma (HCC).
Julie F. Foley, Brian Elgart, Dhiral Phadke, Deepak Mav, Ignacio Tripodi, Nicholas Clausen, Madeleine Weick, Wes Gladwell, Kevin Gerrish, Ruchir Shah, B. Alex Merrick   +10 more
wiley   +1 more source

Advanced models for respiratory disease and drug studies

Medicinal Research Reviews, Volume 43, Issue 5, Page 1470-1503, September 2023., 2023
Abstract The global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed recently, along with increased air pollution and wildfire events, increases the urgency of identifying the most effective therapeutic measures to combat these diseases even ...
Jesus Shrestha, Keshav Raj Paudel, Hojjatollah Nazari, Vivek Dharwal, Sajad Razavi Bazaz, Matt D. Johansen, Kamal Dua, Philip M. Hansbro, Majid Ebrahimi Warkiani   +8 more
wiley   +1 more source

A novel inducible haematopoietic cell‐depleting mouse model for chimeric complementation of blood cells

Cell Proliferation, Volume 56, Issue 5, May 2023., 2023
We established a novel inducible haematopoietic cell‐depleting mouse model and tested the feasibility of using chimeric complementation to regenerate HSCs and their progeny cells. Large populations of syngeneic and major histocompatibility‐mismatched haematopoietic cells were successfully regenerated by this model.
Weiyun Cao, Jiani Cao, Xing Li, Haoyu Xu, Jiayi Tian, Xiaoyan Li, Fengchao Wang, Tongbiao Zhao   +7 more
wiley   +1 more source

Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature

Birth Defects Research, Volume 115, Issue 7, Page 687-709, April 15, 2023., 2023
Abstract Background Based on new testing, we re‐assess U.S. EPA and California OEHHA conclusions regarding male reproductive toxicity associated with cyanide exposure. Methods Literature identified by ATSDR, ECETOC and EPA was complemented by studies conducted after 2006. Relevant studies were scored for quality using ToxRTool. Results Eleven pertinent
Amy Lavin Williams, John M. DeSesso
wiley   +1 more source

Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAGn51trunc Model of Huntington Disease

Frontiers in Neuroscience, 2018
The transgenic rat model of Huntington disease expressing a fragment of mutant HTT (tgHD rat) has been thoroughly characterized and reproduces hallmark symptoms of human adult-onset HD.
Anne-Christine Plank, Fabio Canneva, Kerstin A. Raber, Yvonne K. Urbach, Julia Dobner, Maja Puchades, Jan G. Bjaalie, Clarissa Gillmann, Tobias Bäuerle, Olaf Riess, Hoa H. P. Nguyen, Stephan von Hörsten   +11 more
doaj   +1 more source

Salivary α-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed.
Bertram Catharina, Hass Ralf, Fedrowitz Maren, Löscher Wolfgang   +3 more
doaj   +1 more source

Pressure–natriuretic and hemodynamic adjustments to chronic ACE inhibition in inbred F344 and Lewis rat strains

The FASEB Journal, 2012
Genetic background has a major influence on the severity of renovascular disease. Previously we showed that Lewis rats with inducible hypertension caused by transgenic renin expression have lower blood pressure, higher renal plasma flow (RPF) and glomerular filtration rate (GFR) and are relatively protected from hypertensive renal microvascular injury ...
Robert Ian Menzies, Christopher J Kenyon, John J Mullins, Matthew A Bailey   +3 more
openaire   +1 more source

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Effect of chronic alcohol ingestion on the progression of periodontitis induced in Fisher-344 rats [PDF]

RGO: Revista Gaúcha de Odontologia, 2009
Objective: Understand the effect of chronic alcohol on the progression of periodontitis induced in Fischer-344 rats.Methods: For the study, 22 Fischer-344 rats, two months old were used, divided into groups: alcohol (n=8), ligature (n=7) and control (n=7)
Éder Ricardo Biasoli, Tereza Aparecida Delle Vedove Semenoff, Alex Semenoff Segundo   +2 more
doaj