Results 11 to 20 of about 37 (37)
Inbred F344 rats as a biologic model of intra-abdominal sepsis
Brazilian Journal of Veterinary Research and Animal Science, 2002 Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1. Six hours after inoculation with E.
Damy, Sueli Blanes +5 more
openaire +4 more sources
Impact of the Aversive Effects of Drugs on Their Use and Abuse
Behavioural Neurology, Volume 2022, Issue 1, 2022., 2022 Drug use and abuse are complex issues in that the basis of each may involve different determinants and consequences, and the transition from one to the other may be equally multifaceted. A recent model of the addiction cycle (as proposed by Koob and his colleagues) illustrates how drug‐taking patterns transition from impulsive (acute use) to compulsive
Anthony L. Riley +3 more
wiley +1 more source
Aging Cell, Volume 20, Issue 11, November 2021., 2021 In this study, we reevaluated the effect of the genotype and sex of recombinant inbred strains of mice on their response to dietary restriction. Out of the eight groups studied, half showed an increase in lifespan when the diet was restricted by 40% and the other half either did not respond or showed a decrease in lifespan. The recombinant inbred lines
Archana Unnikrishnan +8 more
wiley +1 more source
The FASEB Journal, 2012 Genetic background has a major influence on the severity of renovascular disease. Previously we showed that Lewis rats with inducible hypertension caused by transgenic renin expression have lower blood pressure, higher renal plasma flow (RPF) and glomerular filtration rate (GFR) and are relatively protected from hypertensive renal microvascular injury ...
John J. Mullins +3 more
openaire +2 more sources
Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?
Health Science Reports, Volume 8, Issue 5, May 2025.ABSTRACT Background and Aim Antiretroviral therapy (ART) has reduced human immunodeficiency virus (HIV)/AIDS to a manageable chronic condition even though no cure exists. Despite ART control, latent HIV infection results in failed memory CD4 T‐cell responses, immune overactivation, inflammation, oxidative stress, genomic instability, deoxyribonucleic ...
Esimebia Adjovi Amegashie +5 more
wiley +1 more source
FASEB BioAdvances, Volume 7, Issue 5, May 2025.Physiology is closely synchronized to daily and seasonal light/dark cycles. Wild‐derived white‐footed mice were housed in long‐day (LD – 16L:8D) or short‐day (SD – 8L:16D) photoperiods at thermoneutrality (27°C). LD selectively increased visceral WAT mass and decreased Adrβ3 and Ucp1 expression while inducing misalignment of clock genes compared to SD.
Margaret E. Newport +6 more
wiley +1 more source
Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats
Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King +23 more
wiley +1 more source
Risks to human and animal health from the presence of bromide in food and feed
EFSA Journal, Volume 23, Issue 1, January 2025.Abstract The European Commission mandated EFSA to assess the toxicity of bromide, the existing maximum residue levels (MRLs), and possible transfer from feed into food of animal origin. The critical effects of bromide in experimental animals are on the thyroid and central nervous system.
EFSA Scientific Committee +34 more
wiley +1 more source
Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives
EFSA Journal, Volume 22, Issue 11, November 2024.Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF) +42 more
wiley +1 more source
Bioprinted research models of urological malignancy
Exploration, Volume 4, Issue 4, August 2024.In this review, a series of bioprinted research models are presented for the fundamental research of urological malignancies. This review summarizes and discusses five aspects, including bioprinting technology, polymer‐based inks, collection of seeding cells, culturing of cancer models, and the applications for biomedical research.
Guanyi Wang +5 more
wiley +1 more source