Results 11 to 20 of about 22,238 (163)
Whole exome and transcript profiling of liver following aflatoxin B1 exposure in rats
Journal of Applied Toxicology, Volume 43, Issue 9, Page 1293-1305, September 2023., 2023 Abstract We recently developed a rat whole exome sequencing (WES) panel and used it to evaluate early somatic mutations in archival liver tissues from F344/N rats exposed to the hepatocarcinogen, Aflatoxin B1 (AFB1), a widely studied, potent mutagen and hepatocarcinogen associated with hepatocellular carcinoma (HCC).
Julie F. Foley +10 more
wiley +1 more source
Advanced models for respiratory disease and drug studies
Medicinal Research Reviews, Volume 43, Issue 5, Page 1470-1503, September 2023., 2023 Abstract The global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed recently, along with increased air pollution and wildfire events, increases the urgency of identifying the most effective therapeutic measures to combat these diseases even ...
Jesus Shrestha +8 more
wiley +1 more source
Cell Proliferation, Volume 56, Issue 5, May 2023., 2023 We established a novel inducible haematopoietic cell‐depleting mouse model and tested the feasibility of using chimeric complementation to regenerate HSCs and their progeny cells. Large populations of syngeneic and major histocompatibility‐mismatched haematopoietic cells were successfully regenerated by this model.
Weiyun Cao +7 more
wiley +1 more source
Frontiers in Neurology, 2015 The rat is the most common animal model for the preclinical validation of neuroprotective therapies in spinal cord injury (SCI). Lipid peroxidation (LP) is a hallmark of the damage triggered after SCI.
Humberto eMestre +8 more
doaj +1 more source
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature
Birth Defects Research, Volume 115, Issue 7, Page 687-709, April 15, 2023., 2023 Abstract Background Based on new testing, we re‐assess U.S. EPA and California OEHHA conclusions regarding male reproductive toxicity associated with cyanide exposure. Methods Literature identified by ATSDR, ECETOC and EPA was complemented by studies conducted after 2006. Relevant studies were scored for quality using ToxRTool. Results Eleven pertinent
Amy Lavin Williams, John M. DeSesso
wiley +1 more source
The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats [PDF]
, 2011 Aim To investigate the site of alloantigen presentation in the rat following orthotopic corneal transplantation. Methods Adult inbred Fischer 344 rats received penetrating corneal allografts from inbred Wistar Furth donors (n¼17), without lymphadenectomy.
Brereton, Helen Mary +4 more
core +1 more source
EFSA Journal, Volume 21, Issue 4, April 2023., 2023 Abstract In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the risks to public health from the presence of BPA in foodstuffs and to establish a tolerable daily intake (TDI). For this re‐evaluation, a pre‐established protocol was
EFSA Panel on Food Contact Materials +37 more
wiley +1 more source
Lymphoma caused by intestinal microbiota. [PDF]
, 2014 The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions ...
Schiestl, Robert H, Yamamoto, Mitsuko L
core +2 more sources
Strain specific effects of low level lead exposure on associative learning and memory in rats. [PDF]
, 2017 Exposure to lead (Pb) remains a significant public health concern. Lead exposure in early life impairs the normal development of numerous cognitive and neurobehavioral processes.
Schneider, J. S., Verma, Megha
core +2 more sources