Results 41 to 50 of about 8,306 (159)

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, Volume 24, Issue 8, August 2025.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. [PDF]

, 2016
Severe, repeated or chronic stress produces negative health outcomes including disruptions of the sleep/wake cycle and gut microbial dysbiosis. Diets rich in prebiotics and glycoproteins impact the gut microbiota and may increase gut microbial species ...
Berg, Brian M, Chichlowski, Maciej, Fleshner, Monika, Greenwood, Benjamin N, Knight, Rob, Mika, Agnieszka, Roller, Rachel, Thompson, Robert S   +7 more
core   +1 more source

Studies on transplantability of four strains of osteosarcoma in inbred F344 rats and successiveness of their bone-forming character.

Japanese Journal of Oral & Maxillofacial Surgery, 1991
A number of transplantable animal models of osteosarcoma have been developed so far, but the available strains of the rat that keep their bone-forming ability through many serial transplantations are limited both in the number of strains and their applicability.
openaire   +2 more sources

Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aim Antiretroviral therapy (ART) has reduced human immunodeficiency virus (HIV)/AIDS to a manageable chronic condition even though no cure exists. Despite ART control, latent HIV infection results in failed memory CD4 T‐cell responses, immune overactivation, inflammation, oxidative stress, genomic instability, deoxyribonucleic ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +5 more
wiley   +1 more source

Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease

Frontiers in Neuroscience
In Huntington disease (HD) the prodromal phase has been increasingly investigated and is currently in focus for early interventional treatments. Also, the influence of sex on disease progression and severity in patients is under discussion, as a sex ...
Veronika Ratz-Wirsching, Veronika Ratz-Wirsching, Johanna Habermeyer, Johanna Habermeyer, Sandra Moceri, Julia Harrer, Christoph Schmitz, Stephan von Hörsten, Stephan von Hörsten   +8 more
doaj   +1 more source

Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats [PDF]

, 2000
Processed meat intake is associated with increased risk of colorectal cancer. This association may be explained by the endogenous formation of N-nitroso compounds (NOC).
Corpet, Denis E., Parnaud, Géraldine, Peiffer, Ginette, Pignatelli, Brigitte, Taché, Sylviane   +4 more
core   +1 more source

Photoperiod influences visceral adiposity and the adipose molecular clock independent of temperature in wild‐derived Peromyscus leucopus

FASEB BioAdvances, Volume 7, Issue 5, May 2025.
Physiology is closely synchronized to daily and seasonal light/dark cycles. Wild‐derived white‐footed mice were housed in long‐day (LD – 16L:8D) or short‐day (SD – 8L:16D) photoperiods at thermoneutrality (27°C). LD selectively increased visceral WAT mass and decreased Adrβ3 and Ucp1 expression while inducing misalignment of clock genes compared to SD.
Margaret E. Newport, Paul Wilson, Shanna Lowes, Marthe Behrends, Alexis Coons, Jeff Bowman, Holly E. Bates   +6 more
wiley   +1 more source

Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure. [PDF]

, 2004
Aging is associated with profound changes in the structure and function of the heart. A fundamental understanding of these processes, using relevant animal models, is required for effective prevention and treatment of cardiovascular disease in the ...
Evgenov, O.V., Haskó, G., Kollai, M., Liaudet, L., Mabley, J.G., Marton, A., Pacher, P., Szabó, C.   +7 more
core   +2 more sources

Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats

Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.
A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King, Apurva S. Chitre, Joel D. Leal‐Gutiérrez, Jordan A. Tripi, Alesa H. Netzley, Aidan P. Horvath, Alexander C. Lamparelli, Anthony George, Connor Martin, Celine L. St. Pierre, Thiago Missfeldt Sanches, Hannah V. Bimschleger, Jianjun Gao, Riyan Cheng, Khai‐Minh Nguyen, Katie L. Holl, Oksana Polesskaya, Keita Ishiwari, Hao Chen, Terry E. Robinson, Shelly B. Flagel, Leah C. Solberg Woods, Abraham A. Palmer, Paul J. Meyer   +23 more
wiley   +1 more source

High-resolution genome screen for bone mineral density in heterogeneous stock rat [PDF]

, 2014
We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model ...
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Dieze, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +15 more
core   +1 more source