Results 51 to 60 of about 8,306 (159)

Risks to human and animal health from the presence of bromide in food and feed

EFSA Journal, Volume 23, Issue 1, January 2025.
Abstract The European Commission mandated EFSA to assess the toxicity of bromide, the existing maximum residue levels (MRLs), and possible transfer from feed into food of animal origin. The critical effects of bromide in experimental animals are on the thyroid and central nervous system.
EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford   +34 more
wiley   +1 more source

Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives

EFSA Journal, Volume 22, Issue 11, November 2024.
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Monika Batke, Ellen Bruzell, James Chipman, Karlien Cheyns, Riccardo Crebelli, Cristina Fortes, Peter Fürst, Thorhallur Halldorsson, Jean‐Charles LeBlanc, Manuela Mirat, Oliver Lindtner, Alicja Mortensen, Evangelia Ntzani, Romina Shah, Heather Wallace, Matthew Wright, Stefania Barmaz, Consuelo Civitella, Petra Georgelova, Federica Lodi, Elena Mazzoli, Josef Rasinger, Ana Maria Rincon, Alexandra Tard, Panagiota Zakidou, Maged Younes   +42 more
wiley   +1 more source

Bioprinted research models of urological malignancy

Exploration, Volume 4, Issue 4, August 2024.
In this review, a series of bioprinted research models are presented for the fundamental research of urological malignancies. This review summarizes and discusses five aspects, including bioprinting technology, polymer‐based inks, collection of seeding cells, culturing of cancer models, and the applications for biomedical research.
Guanyi Wang, Xiongmin Mao, Wang Wang, Xiaolong Wang, Sheng Li, Zijian Wang   +5 more
wiley   +1 more source

Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking [PDF]

, 2017
Background A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats.
Bell, Richard L., Ding, Zheng-Ming, Hauser, Sheketha R., Ingraham, Cynthia M., Lasek, Amy W., McBride, William J.   +5 more
core   +1 more source

Re‐evaluation of guar gum (E 412) as a food additive in foods for infants below 16 weeks of age and follow‐up of its re‐evaluation as food additive for uses in foods for all population groups

EFSA Journal, Volume 22, Issue 5, May 2024.
Abstract Guar gum (E 412) was re‐evaluated in 2017 by the former EFSA Panel on Food Additives and Nutrient sources added to Food (ANS). As a follow‐up to this assessment, the Panel on Food Additives and Flavourings (FAF) was requested to assess the safety of guar gum (E 412) for its uses as food additive in food for infants below 16 weeks of age ...
EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Rainer Gürtler, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Birgit Dusemund, Alicja Mortensen, Dominique Turck, Detlef Wölfle, Stefania Barmaz, Agnieszka Mech, Alexandra Tard, Ursula Gundert‐Remy   +25 more
wiley   +1 more source

Differential Behavioral Responses to\ud Cocaethylene of Long-Evans and\ud Sprague-Dawley Rats: Role of Serotonin [PDF]

, 1997
Cocaethylene is a neuroactive metabolite derived from the concurrent consumption of cocaine and ethanol. The effects of cocaethylene on locomotor activity, stereotypy, and rearing in Long-Evans and Sprague-Dawley rats were compared.A single cocaine ...
Horowitz, Dr. J.M., Kristal, Dr. M.B., Torres, Dr. G.   +2 more
core  

Genetic background and sex influence somatosensory sensitivity and oxycodone analgesia in the Hybrid Rat Diversity Panel

Genes, Brain and Behavior, Volume 23, Issue 2, April 2024.
Using the Hybrid Rat Diversity Panel, we demonstrated that sex and genetic background confer differences in mechanical sensitivity, thermal sensitivity, and oxycodone‐induced analgesia. Created with BioRender.com. Abstract Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how ...
Eamonn P. Duffy, J. O. Ward, L. H. Hale, K. T. Brown, Andrew J. Kwilasz, Laura M. Saba, Marissa A. Ehringer, Ryan K. Bachtell   +7 more
wiley   +1 more source

Long term methionine restriction: Influence on gut microbiome and metabolic characteristics

Aging Cell, Volume 23, Issue 3, March 2024.
A long‐term Methionine restriction diet in mice had less impact on the gut microbiome compared to short‐term feeding, with aging showing more significant effects on bacterial taxa. Specific dietary changes in bacterial taxa occurred at 1 or 18‐week intervals, while consistent age‐related changes were noted in certain taxa across both diet groups ...
Akash Nagarajan, Alexander Tate Lasher, Casey D. Morrow, Liou Y. Sun   +3 more
wiley   +1 more source

A Brain Motivated to Play: Insights into the Neurobiology of Playfulness

, 2016
Play is an important part of normal childhood development and is seen in varied forms among many mammals. While not indispensable to normal development, playful social experiences as juveniles may provide an opportunity to develop flexible behavioural ...
Siviy, Stephen M.
core   +1 more source

Recent Advances in Genetics of the Spontaneously Hypertensive Rat [PDF]

, 2010
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. Multiple quantitative trait loci associated with hemodynamic and metabolic parameters have been mapped in the ...
Michal Pravenec, Theodore W. Kurtz
core   +3 more sources