, 2015 Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning.
Akopian, Garnik +5 more
core +1 more source
Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study.
PLoS ONE, 2018 A majority of patients with orofacial cleft deformity requires cleft repair through a bone graft. However, elevated amount of bone resorption and subsequent bone graft failure remains a significant clinical challenge.
Christine Hong +10 more
doaj +1 more source
The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background [PDF]
, 2015 Chronic exposure to cocaine induces modifications to neurons in the brain regions involved in addiction. Hence, we evaluated cocaine-induced changes in the hippocampal CA1 field in Fischer 344 (F344) and Lewis (LEW) rats, 2 strains that have been widely ...
Ambrosio, Emilio +6 more
core +2 more sources
Fetal-Adult Cardiac Transcriptome Analysis in Rats with Contrasting Left Ventricular Mass Reveals New Candidates for Cardiac Hypertrophy [PDF]
, 2015 Reactivation of fetal gene expression patterns has been implicated in common cardiac diseases in adult life including left ventricular (LV) hypertrophy (LVH) in arterial hypertension.
Grabowski, Katja +6 more
core +3 more sources
Genetic loci for ventricular dilatation in the LEW/Jms rat with fetal-onset hydrocephalus are influenced by gender and genetic background [PDF]
, 2005 Background The LEW/Jms rat strain has inherited hydrocephalus, with more males affected than females and an overall expression rate of 28%. This study aimed to determine chromosomal positions for genetic loci causing the hydrocephalus.
Mayorga David A +4 more
core +2 more sources
Sex Differences in Metabolite–Immune Circuits of Neuroinflammation
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan +6 more
wiley +1 more source
Gene expression microarray analysis of early oxygen-induced retinopathy in the rat [PDF]
, 2009 Different inbred strains of rat differ in their susceptibility to oxygen-induced retinopathy (OIR), an animal model of human retinopathy of prematurity. We examined gene expression in Sprague–Dawley (susceptible) and Fischer 344 (resistant) neonatal rats
Melinda Tea +52 more
core +1 more source
Updated Neuronal Numbers of the Rat Hippocampal Formation: Redesigning the Hippocampal Model
Hippocampus, Volume 36, Issue 1, January 2026.ABSTRACT The hippocampal formation is a functional entity that includes the hippocampus, subicular complex, and the entorhinal cortex, and has an essential role in learning and memory, emotional processing, and spatial coding. The well‐defined structure of hippocampal fields and the segregation of the connections have made this structure a favorite ...
Jon I. Arellano, Pasko Rakic
wiley +1 more source
Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains [PDF]
, 2009 Background Cognitive function might be affected by the subjects' emotional reactivity. We assessed whether behavior in different tests of emotional reactivity is correlated with performance in aversively motivated learning tasks, using four strains of ...
van der Staay, F.J. +7 more
core +2 more sources
Cutaneous photosensitivity of phototheranostic porphyrin–lipid nanoparticles
Photochemistry and Photobiology, Volume 101, Issue 6, Page 1541-1558, November/December 2025.Porphyrin‐lipid nanoparticles (PORPHYSOMES) exhibit significantly less severe and shorter‐lasting skin photosensitivity to sunlight compared to a therapeutically equivalent dose of porfimer sodium (PHOTOFRIN) in a rat skin model. The difference was due to altered intradermal distribution and faster clearance of PORPHYSOMES from skin after intravenous ...
Michael S. Valic +20 more
wiley +1 more source