Results 11 to 20 of about 7,066 (108)

The evidence for old age motor neuron death: A scoping review. [PDF]

Physiol Rep
We systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Cheung SW, Fogarty MJ.
europepmc   +2 more sources

Statement on the findings presented in the Toxicological Profile for Mercury issued by the US ATSDR. [PDF]

EFSA J
Abstract The European Food Safety Authority (EFSA) was requested by the European Commission to deliver a statement on the findings presented in the Toxicological Profile for Mercury issued by the US Agency for Toxic Substances and Disease Registry (ATSDR) in 2024. The statement was endorsed by the CONTAM Panel before approval by EFSA. Although some key
European Food Safety Authority (EFSA), Bastaki M, Eskes C, Halldorsson T, Muñoz Guajardo IP, Vejdovszky K, Viviani B, Steinkellner H.   +7 more
europepmc   +2 more sources

Early Alterations in Operant Performance and Prominent Huntingtin Aggregation in a Congenic F344 Rat Line of the Classical CAGn51trunc Model of Huntington Disease

Frontiers in Neuroscience, 2018
The transgenic rat model of Huntington disease expressing a fragment of mutant HTT (tgHD rat) has been thoroughly characterized and reproduces hallmark symptoms of human adult-onset HD.
Anne-Christine Plank, Fabio Canneva, Kerstin A. Raber, Yvonne K. Urbach, Julia Dobner, Maja Puchades, Jan G. Bjaalie, Clarissa Gillmann, Tobias Bäuerle, Olaf Riess, Hoa H. P. Nguyen, Stephan von Hörsten   +11 more
doaj   +1 more source

Pressure–natriuretic and hemodynamic adjustments to chronic ACE inhibition in inbred F344 and Lewis rat strains

The FASEB Journal, 2012
Genetic background has a major influence on the severity of renovascular disease. Previously we showed that Lewis rats with inducible hypertension caused by transgenic renin expression have lower blood pressure, higher renal plasma flow (RPF) and glomerular filtration rate (GFR) and are relatively protected from hypertensive renal microvascular injury ...
Robert Ian Menzies, Christopher J Kenyon, John J Mullins, Matthew A Bailey   +3 more
openaire   +1 more source

Salivary α-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed.
Bertram Catharina, Hass Ralf, Fedrowitz Maren, Löscher Wolfgang   +3 more
doaj   +1 more source

Effect of chronic alcohol ingestion on the progression of periodontitis induced in Fisher-344 rats [PDF]

RGO: Revista Gaúcha de Odontologia, 2009
Objective: Understand the effect of chronic alcohol on the progression of periodontitis induced in Fischer-344 rats.Methods: For the study, 22 Fischer-344 rats, two months old were used, divided into groups: alcohol (n=8), ligature (n=7) and control (n=7)
Éder Ricardo Biasoli, Tereza Aparecida Delle Vedove Semenoff, Alex Semenoff Segundo   +2 more
doaj  

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon

BMC Gastroenterology, 2009
Background Blueberries may lower relative risk for cancers of the gastrointestinal tract. Previous work indicated an inhibitory effect of consumed blueberry (BB) on formation of aberrant crypt foci (ACF) in colons of male Fisher F344 rats (inbred strain).
Wu Xianli, Frank Julie A, Simmen Frank A, Xiao Rijin, Hennings Leah J, Prior Ronald L   +5 more
doaj   +1 more source

Screening and Analysis of Microsatellite Genetic Markers in Commonly Used Inbred Rat Strains

Shiyan dongwu yu bijiao yixue
ObjectiveTo screen a set of short tandem repeat (STR) markers covering rat chromosomes 1-20 and the X chromosome, with 2-4 markers on each chromosome, and establish a dedicated marker panel for genetic contamination detection and strain identification of
TANG Jianping, ZHAO Liya, ZHAO Ying
doaj   +1 more source

Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study.

PLoS ONE, 2018
A majority of patients with orofacial cleft deformity requires cleft repair through a bone graft. However, elevated amount of bone resorption and subsequent bone graft failure remains a significant clinical challenge.
Christine Hong, Alison Quach, Lawrence Lin, Jeffrey Olson, Taewoo Kwon, Olga Bezouglaia, Jaime Tran, Michael Hoang, Kimberly Bui, Reuben H Kim, Sotirios Tetradis   +10 more
doaj   +1 more source