Results 11 to 20 of about 7,063 (108)

Hypoglossal and lumbar motor neuron death in old Sprague-Dawley rats. [PDF]

Physiol Rep
Hypoglossal and lumbar motor neurons (MNs) surival is essential for maintiaining neuromotor health into old age. We observed loss of predominantly larger hypoglossal and lumbar MNs in 24 compared to 6 months old Sprague‐Dawley rats. This shows MN loss in old age is common between rat strains and is similar to elderly humans.
Cheung SW, Bjerke L, Dasgupta D, Sieck GC, Fogarty MJ.   +4 more
europepmc   +2 more sources

The evidence for old age motor neuron death: A scoping review. [PDF]

Physiol Rep
We systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Cheung SW, Fogarty MJ.
europepmc   +2 more sources

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats. [PDF]

Aging Cell
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Biswas S, Nguyen HVM, Converse A, Matsuzaki S, Kinter MT, Humphries KM, Freeman WM, Ocañas SR, Richardson A, Duncan FE, Lewis TL, Stout MB.   +11 more
europepmc   +2 more sources

Statement on the findings presented in the Toxicological Profile for Mercury issued by the US ATSDR. [PDF]

EFSA J
Abstract The European Food Safety Authority (EFSA) was requested by the European Commission to deliver a statement on the findings presented in the Toxicological Profile for Mercury issued by the US Agency for Toxic Substances and Disease Registry (ATSDR) in 2024. The statement was endorsed by the CONTAM Panel before approval by EFSA. Although some key
European Food Safety Authority (EFSA), Bastaki M, Eskes C, Halldorsson T, Muñoz Guajardo IP, Vejdovszky K, Viviani B, Steinkellner H.   +7 more
europepmc   +2 more sources

Inhalation of 1-bromopropane alters hippocampal expression of pathways related to immune system/inflammation and insulin signaling in experimental rats [PDF]

Scientific Reports
1-Bromopropane, an alternative to ozone-depleting solvents, exhibits neurotoxicity in humans and rats. The aim of the present study was to identify the genes or signaling pathways involved in the neurotoxicity and hepatotoxicity of 1-bomopropane in two ...
Fen Huang, Sahoko Ichihara, Ying Cheng, Wataru Fujibuchi, Emiko Kitagawa, Satomi Mizukami, Hitoshi Iwahashi, Sahabudeen Sheik Mohideen, Junzoh Kitoh, Seiichiroh Ohsako, Yousra Reda, Cai Zong, Gaku Ichihara   +12 more
doaj   +2 more sources

Hi-C sequencing data from frontal cortex of laboratory rats [PDF]

Scientific Data
The three-dimensional structure of chromosomes is integral to nuclear organization and influences processes such as DNA replication, repair, and gene expression.
Panjun Kim, Rachel R. Ward, Burt M. Sharp, Robert W. Williams, Hao Chen   +4 more
doaj   +2 more sources

Salivary α-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed.
Bertram Catharina, Hass Ralf, Fedrowitz Maren, Löscher Wolfgang   +3 more
doaj   +1 more source

Effect of chronic alcohol ingestion on the progression of periodontitis induced in Fisher-344 rats [PDF]

RGO: Revista Gaúcha de Odontologia, 2009
Objective: Understand the effect of chronic alcohol on the progression of periodontitis induced in Fischer-344 rats.Methods: For the study, 22 Fischer-344 rats, two months old were used, divided into groups: alcohol (n=8), ligature (n=7) and control (n=7)
Éder Ricardo Biasoli, Tereza Aparecida Delle Vedove Semenoff, Alex Semenoff Segundo   +2 more
doaj  

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon

BMC Gastroenterology, 2009
Background Blueberries may lower relative risk for cancers of the gastrointestinal tract. Previous work indicated an inhibitory effect of consumed blueberry (BB) on formation of aberrant crypt foci (ACF) in colons of male Fisher F344 rats (inbred strain).
Wu Xianli, Frank Julie A, Simmen Frank A, Xiao Rijin, Hennings Leah J, Prior Ronald L   +5 more
doaj   +1 more source