Results 21 to 30 of about 8,306 (159)

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]

, 2014
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt, Galione, Antony, He, Hong, Hessner, Martin, Hoffmann, Raymond G., Holl, Katie, Jacob, Howard, Jia, Shuang, Kaldunski, Mary, Li, Shun-Hua, Meigs, James, Parrington, John, Ruas da Silva, Margarida, Simpson, Pippa, Solberg Woods, Leah C., Stoddard, Alex, Tsaih, Shirng-Wern, Tschannen, Michael, Wiederhold, Andrew   +18 more
core   +1 more source

Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats [PDF]

, 2012
To investigate whether expression of an anti-CD4 antibody fragment (scFv) by a lentivector-transduced donor cornea can prolong rat corneal allograft survival.
Appleby, Sarah Louise, Brereton, Helen Mary, Coster, Douglas John, Jessup, Claire Frances, Kirk, Kirsty, Mortimer, Lauren A, Tan, Chuan K, Williams, Keryn Anne   +7 more
core   +1 more source

Pressure–natriuretic and hemodynamic adjustments to chronic ACE inhibition in inbred F344 and Lewis rat strains

The FASEB Journal, 2012
Genetic background has a major influence on the severity of renovascular disease. Previously we showed that Lewis rats with inducible hypertension caused by transgenic renin expression have lower blood pressure, higher renal plasma flow (RPF) and glomerular filtration rate (GFR) and are relatively protected from hypertensive renal microvascular injury ...
Robert Ian Menzies, Christopher J Kenyon, John J Mullins, Matthew A Bailey   +3 more
openaire   +1 more source

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Effect of photoperiodicity in the pregnancy rate of isogenic rats (F344) [PDF]

, 2011
O uso de animais isogênicos apresenta grandes vantagens experimentais, como uniformidade fenotípica e genotípica (reduzindo o número de animais em experimentos) e histocompatibilidade, permitindo, assim, o acúmulo de informações e a repetibilidade dos ...
Alves, Alexandre José, Alves, Flávio Ribeiro, Baptista, Alexandre Bastos, Ferreira, Amanda Olivotti, Guerra, Ricardo Romão, Miglino, Maria Angélica, Morita, Erika Lissa, Passos, Cristiane Carlin   +7 more
core   +2 more sources

Effect of chronic alcohol ingestion on the progression of periodontitis induced in Fisher-344 rats [PDF]

RGO: Revista Gaúcha de Odontologia, 2009
Objective: Understand the effect of chronic alcohol on the progression of periodontitis induced in Fischer-344 rats.Methods: For the study, 22 Fischer-344 rats, two months old were used, divided into groups: alcohol (n=8), ligature (n=7) and control (n=7)
Éder Ricardo Biasoli, Tereza Aparecida Delle Vedove Semenoff, Alex Semenoff Segundo   +2 more
doaj  

Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon

BMC Gastroenterology, 2009
Background Blueberries may lower relative risk for cancers of the gastrointestinal tract. Previous work indicated an inhibitory effect of consumed blueberry (BB) on formation of aberrant crypt foci (ACF) in colons of male Fisher F344 rats (inbred strain).
Wu Xianli, Frank Julie A, Simmen Frank A, Xiao Rijin, Hennings Leah J, Prior Ronald L   +5 more
doaj   +1 more source

Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]

, 2015
We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Diez, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Mont-Cardona, Carme, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +16 more
core   +1 more source

Strain specific effects of low level lead exposure on associative learning and memory in rats. [PDF]

, 2017
Exposure to lead (Pb) remains a significant public health concern. Lead exposure in early life impairs the normal development of numerous cognitive and neurobehavioral processes.
Schneider, J. S., Verma, Megha
core   +2 more sources

Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD [PDF]

, 2013
BACKGROUND: The Rat Genome Database (RGD) ( http://rgd.mcw.edu/) is the premier site for comprehensive data on the different strains of the laboratory rat (Rattus norvegicus).
Diane H Munzenmaier, Elizabeth A Worthey, Howard J Jacob, Mary Shimoyama, Melinda R Dwinell, Rajni Nigam   +5 more
core   +2 more sources