Results 21 to 30 of about 7,025 (110)

Mitochondrial‐Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC‐HETB/W Rat

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Multi‐omics profiling uncovers the effect of sex and mitochondrial‐haplotype on molecular fingerprints of aging in plasma. ABSTRACT The effect of mitochondrial‐haplotype (mt‐haplotype) on aging was studied using a unique rat model (OKC‐HETB/W), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B‐haplotype)
Hoang Van M. Nguyen, Finterly Hu, Evaniya Shakya, Chloe Fender, Kenneth Lee, Jason Schindler, Manuel Garcia‐Jaramillo, Nagib Ahsan, Janet C. Siebert, Sarah J. Borengasser, Norman G. Hord, Michael B. Stout, Steven Austad, Arlan Richardson   +13 more
wiley   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source

Updated Neuronal Numbers of the Rat Hippocampal Formation: Redesigning the Hippocampal Model

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT The hippocampal formation is a functional entity that includes the hippocampus, subicular complex, and the entorhinal cortex, and has an essential role in learning and memory, emotional processing, and spatial coding. The well‐defined structure of hippocampal fields and the segregation of the connections have made this structure a favorite ...
Jon I. Arellano, Pasko Rakic
wiley   +1 more source

Studies on transplantability of four strains of osteosarcoma in inbred F344 rats and successiveness of their bone-forming character.

Japanese Journal of Oral & Maxillofacial Surgery, 1991
A number of transplantable animal models of osteosarcoma have been developed so far, but the available strains of the rat that keep their bone-forming ability through many serial transplantations are limited both in the number of strains and their applicability.
openaire   +2 more sources

Cutaneous photosensitivity of phototheranostic porphyrin–lipid nanoparticles

Photochemistry and Photobiology, Volume 101, Issue 6, Page 1541-1558, November/December 2025.
Porphyrin‐lipid nanoparticles (PORPHYSOMES) exhibit significantly less severe and shorter‐lasting skin photosensitivity to sunlight compared to a therapeutically equivalent dose of porfimer sodium (PHOTOFRIN) in a rat skin model. The difference was due to altered intradermal distribution and faster clearance of PORPHYSOMES from skin after intravenous ...
Michael S. Valic, Mark Zheng, Theo Husby, Keegan Guidolin, Axel Sahovaler, Sharon Tzelnick, Wenlei Jiang, Michael Halim, Pamela Schimmer, Abdullah El‐Sayes, Chris J. Zhang, Tina Ye, Ivan Kosik, Jason L. Townson, Kenneth K. Ng, Lili Ding, Juan Chen, Jonathan C. Irish, Robert Weersink, Brian C. Wilson, Gang Zheng   +20 more
wiley   +1 more source

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, Volume 24, Issue 8, August 2025.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aim Antiretroviral therapy (ART) has reduced human immunodeficiency virus (HIV)/AIDS to a manageable chronic condition even though no cure exists. Despite ART control, latent HIV infection results in failed memory CD4 T‐cell responses, immune overactivation, inflammation, oxidative stress, genomic instability, deoxyribonucleic ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +5 more
wiley   +1 more source

Gene-dosage- and sex-dependent differences in the prodromal-Like phase of the F344tgHD rat model for Huntington disease

Frontiers in Neuroscience
In Huntington disease (HD) the prodromal phase has been increasingly investigated and is currently in focus for early interventional treatments. Also, the influence of sex on disease progression and severity in patients is under discussion, as a sex ...
Veronika Ratz-Wirsching, Veronika Ratz-Wirsching, Johanna Habermeyer, Johanna Habermeyer, Sandra Moceri, Julia Harrer, Christoph Schmitz, Stephan von Hörsten, Stephan von Hörsten   +8 more
doaj   +1 more source

Photoperiod influences visceral adiposity and the adipose molecular clock independent of temperature in wild‐derived Peromyscus leucopus

FASEB BioAdvances, Volume 7, Issue 5, May 2025.
Physiology is closely synchronized to daily and seasonal light/dark cycles. Wild‐derived white‐footed mice were housed in long‐day (LD – 16L:8D) or short‐day (SD – 8L:16D) photoperiods at thermoneutrality (27°C). LD selectively increased visceral WAT mass and decreased Adrβ3 and Ucp1 expression while inducing misalignment of clock genes compared to SD.
Margaret E. Newport, Paul Wilson, Shanna Lowes, Marthe Behrends, Alexis Coons, Jeff Bowman, Holly E. Bates   +6 more
wiley   +1 more source

Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats

Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.
A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King, Apurva S. Chitre, Joel D. Leal‐Gutiérrez, Jordan A. Tripi, Alesa H. Netzley, Aidan P. Horvath, Alexander C. Lamparelli, Anthony George, Connor Martin, Celine L. St. Pierre, Thiago Missfeldt Sanches, Hannah V. Bimschleger, Jianjun Gao, Riyan Cheng, Khai‐Minh Nguyen, Katie L. Holl, Oksana Polesskaya, Keita Ishiwari, Hao Chen, Terry E. Robinson, Shelly B. Flagel, Leah C. Solberg Woods, Abraham A. Palmer, Paul J. Meyer   +23 more
wiley   +1 more source