Results 21 to 30 of about 22,238 (163)

Slc:Wistar outbred rats show close genetic similarity with F344 inbred rats

Experimental animals, 2014
Although Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats.
S. Nakanishi, T. Serikawa, T. Kuramoto
semanticscholar   +1 more source

Salivary α-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2011
Background Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed.
Bertram Catharina, Hass Ralf, Fedrowitz Maren, Löscher Wolfgang   +3 more
doaj   +1 more source

Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]

, 2015
We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul, Baud, Amelie, Blázquez, Gloria, Cañete, Toni, Diez, Margarita, Díaz-Morán, Sira, Econs, Michael J., Fernández-Teruel, Alberto, Foroud, Tatiana, Johannesson, Martina, Koller, Daniel L., López-Aumatell, Regina, Martínez-Membrives, Esther, Mont-Cardona, Carme, Olsson, Tomas, Stridh, Pernilla, Tobeña, Adolf   +16 more
core   +1 more source

Inbred F344 rats as a biologic model of intra-abdominal sepsis

, 2002
Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1.
S. Damy, L. Ebisui, M. Spinelli, J. Osaka, E. Tolosa, S. C. B. C. Ortiz   +5 more
semanticscholar   +1 more source

Efficient gene targeting by homologous recombination in rat embryonic stem cells.

PLoS ONE, 2010
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination.
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon   +6 more
doaj   +1 more source

Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD [PDF]

, 2013
BACKGROUND: The Rat Genome Database (RGD) ( http://rgd.mcw.edu/) is the premier site for comprehensive data on the different strains of the laboratory rat (Rattus norvegicus).
Diane H Munzenmaier, Elizabeth A Worthey, Howard J Jacob, Mary Shimoyama, Melinda R Dwinell, Rajni Nigam   +5 more
core   +2 more sources

Genetic and cellular factors in the immune response. 3. The cellular response to poly(Glu52Lys33Tyr15) in the highly responding ACI and poorly responding F344 strains of inbred rats.

Journal of Immunology, 1971
The antibody response in the inbred rat is controlled by at least two autosomal genes; in addition, there is a sex influence which may include both additional genetic factors and environmental influences (1–3).
T. Gill, J. Enderlé, R. Germain, C. Ladoulis   +3 more
semanticscholar   +1 more source

Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon

BMC Gastroenterology, 2009
Background Blueberries may lower relative risk for cancers of the gastrointestinal tract. Previous work indicated an inhibitory effect of consumed blueberry (BB) on formation of aberrant crypt foci (ACF) in colons of male Fisher F344 rats (inbred strain).
Wu Xianli, Frank Julie A, Simmen Frank A, Xiao Rijin, Hennings Leah J, Prior Ronald L   +5 more
doaj   +1 more source

The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background [PDF]

, 2015
Chronic exposure to cocaine induces modifications to neurons in the brain regions involved in addiction. Hence, we evaluated cocaine-induced changes in the hippocampal CA1 field in Fischer 344 (F344) and Lewis (LEW) rats, 2 strains that have been widely ...
Ambrosio, Emilio, Ballesteros-Yañez, Inmaculada, Coria, Santiago M., Felipe Oroquieta, Javier de, Kastanauskaite, Asta, Miguens Vázquez, Miguel, Selvas, Abraham   +6 more
core   +2 more sources

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]

, 2014
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt, Galione, Antony, He, Hong, Hessner, Martin, Hoffmann, Raymond G., Holl, Katie, Jacob, Howard, Jia, Shuang, Kaldunski, Mary, Li, Shun-Hua, Meigs, James, Parrington, John, Ruas da Silva, Margarida, Simpson, Pippa, Solberg Woods, Leah C., Stoddard, Alex, Tsaih, Shirng-Wern, Tschannen, Michael, Wiederhold, Andrew   +18 more
core   +1 more source