Using the Hybrid Rat Diversity Panel, we demonstrated that sex and genetic background confer differences in mechanical sensitivity, thermal sensitivity, and oxycodone‐induced analgesia. Created with BioRender.com. Abstract Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how ...
Eamonn P. Duffy+7 more
wiley +1 more source
Cerebellar output controls generalized spike-and-wave discharge occurence [PDF]
© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0)
Alva, Parimala+15 more
core +4 more sources
Long term methionine restriction: Influence on gut microbiome and metabolic characteristics
A long‐term Methionine restriction diet in mice had less impact on the gut microbiome compared to short‐term feeding, with aging showing more significant effects on bacterial taxa. Specific dietary changes in bacterial taxa occurred at 1 or 18‐week intervals, while consistent age‐related changes were noted in certain taxa across both diet groups ...
Akash Nagarajan+3 more
wiley +1 more source
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure. [PDF]
Aging is associated with profound changes in the structure and function of the heart. A fundamental understanding of these processes, using relevant animal models, is required for effective prevention and treatment of cardiovascular disease in the ...
Evgenov, O.V.+7 more
core +2 more sources
Aim: This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)? Material and Methods: The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY).
Gabriela Ezequiel Oliveira+9 more
wiley +1 more source
Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats [PDF]
Processed meat intake is associated with increased risk of colorectal cancer. This association may be explained by the endogenous formation of N-nitroso compounds (NOC).
Corpet, Denis E.+4 more
core +1 more source
Positional identification and functional analysis of genes regulating autoimmune arthritis [PDF]
The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA).
Yau, Anthony Chun Yeung
core +1 more source
Positional identification of variants of Adamts16 linked to inherited hypertension [PDF]
A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two genes, LOC306664 and LOC306665.
Achinike, Ovokeraye H.+25 more
core
A Brain Motivated to Play: Insights into the Neurobiology of Playfulness
Play is an important part of normal childhood development and is seen in varied forms among many mammals. While not indispensable to normal development, playful social experiences as juveniles may provide an opportunity to develop flexible behavioural ...
Siviy, Stephen M.
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Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells [PDF]
Germline competent embryonic stem (ES) cells can serve as a tool to create genetically engineered rat strains used to elucidate gene function or provide disease models.
Anagha S. Bock+2 more
core +1 more source