K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine [PDF]
, 2017 Pulmonary carcinomas induced by N-nitrosobis(2-oxopropyl) amine (BOP) in WBN/Kob rats were screened for point mutations in the K-ras protooncogene. Exons 1 and 2 were polymerase chain reaction amplified from paraffin-embedded sections, followed by direct
Furukawa, Fumio +3 more
core
Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection [PDF]
, 2014 We previously found that estrogen exerts a novel protective effect on mitochondria in brain vasculature. Here we demonstrate in rat cerebral blood vessels that 17beta-estradiol (estrogen), both in vivo and ex vivo, affects key transcriptional ...
C. Stirone +4 more
core +3 more sources
Predicting the Carcinogenicity of Chemicals in Humans from Rodent Bioassay Data [PDF]
, 2010 Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to know a chemical's carcinogenic potency (with confidence
Goodman, Gay, Wilson, Richard
core +1 more source
Stability of small non-coding RNA reference gene expression in the rat retina during exposure to cyclic hyperoxia [PDF]
, 2013 Purpose: Oxygen-induced retinopathy (OIR) is a robust animal model of human retinopathy of prematurity that readily allows changes in retinal gene and microRNA (miRNA) expression in response to fluctuations in oxygen levels to be studied.
Brereton, Helen Mary +3 more
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Impact of aging on the auditory system and related cognitive functions: A narrative review [PDF]
, 2018 Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world’s population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on ...
Friedland, Peter L +3 more
core +3 more sources
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
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The amphetamine sensitization model of schizophrenia: relevance beyond psychotic symptoms? [PDF]
, 2018 Rationale: A sensitized dopamine system may be linked to the genesis of psychotic symptoms in schizophrenia. Following withdrawal from amphetamine exposures, psychotic-like traits have been robustly demonstrated, but the presence of cognitive/mnemonic ...
Feldon, Joram +3 more
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Trichloroethylene-induced formic aciduria: effect of dose, sex and strain of rat. [PDF]
The industrial solvent trichloroethylene (TCE) has been reported to increase the excretion of formic acid in the urine of male Fischer 344 (F-344) rats following large oral doses.
Evans, AR, Lock, EA, Yaqoob, N
core
Slc:Wistar outbred rats show close genetic similarity with F344 inbred rats
Slc:Wistar outbred rats show close genetic similarity with F344 inbred ratsAlthough Slc:Wistar rats are used widely in biomedical research as outbred rats, close similarities in growth curves, survival rates, and immunological and biochemical phenotypes have been reported between Slc:Wistar and F344 inbred rats. We reported previously that nine genetic variations that were fixed in Slc:Wistar rats had identical genotypes in ...
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