Predicting the Carcinogenicity of Chemicals in Humans from Rodent Bioassay Data [PDF]
, 2010 Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to know a chemical's carcinogenic potency (with confidence
Goodman, Gay, Wilson, Richard
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Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis [PDF]
, 2018 Previous studies have suggested that macrophages may contribute to acute Leptospira dissemination, as well as having a major role in kidney fibrosis. Our aim was to characterize the role of macrophages and galectin 3 (Gal-3) on the survival, clinical ...
Carrera Silva, Eugenio Antonio +10 more
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Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]
, 2015 Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
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Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
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A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. [PDF]
, 2019 Alzheimer's disease (AD) and mixed dementia (MxD) comprise the majority of dementia cases in the growing global aging population. MxD describes the coexistence of AD pathology with vascular pathology, including cerebral small vessel disease (SVD ...
Ahmadian +160 more
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The amphetamine sensitization model of schizophrenia: relevance beyond psychotic symptoms? [PDF]
, 2018 Rationale: A sensitized dopamine system may be linked to the genesis of psychotic symptoms in schizophrenia. Following withdrawal from amphetamine exposures, psychotic-like traits have been robustly demonstrated, but the presence of cognitive/mnemonic ...
Feldon, Joram +3 more
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Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats
Functional & Integrative Genomics, 2010 Imranul Alam +7 more
semanticscholar +1 more source
Trichloroethylene-induced formic aciduria: effect of dose, sex and strain of rat. [PDF]
The industrial solvent trichloroethylene (TCE) has been reported to increase the excretion of formic acid in the urine of male Fischer 344 (F-344) rats following large oral doses.
Evans, AR, Lock, EA, Yaqoob, N
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Drinking pattern matters: effects on maternal care and offspring vulnerability to alcohol in rats [PDF]
, 2015 Alcohol drinking during pregnancy and post-partum period is a major concern because of the persistent neurobehavioral deficits in the offspring, which include increased vulnerability to substance abuse (1). The intermittent pattern of alcohol consumption
BRANCATO, Anna +4 more
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