Results 41 to 50 of about 16,180 (167)
Japanese Journal of Pharmacology, 1987 Fischer 344 (F344), Lewis (LEW), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were chronically fed food containing pentobarbital on an escalating drug dosage schedule over a period of 47 days.
T. Suzuki +4 more
semanticscholar +1 more source
Journal of Separation Science, Volume 47, Issue 22, November 2024.ABSTRACT Deficiency of cofactors for various enzymes can lead to inborn errors of metabolism. These conditions frequently occur as seizures, which lead to permanent brain damage. Newborn screening for biomarkers associated with these disorders can help in early detection and treatment.
Arya Raveendran +4 more
wiley +1 more source
Fine mapping of bone structure and strength QTLs in heterogeneous stock rat [PDF]
, 2015 We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for
Alam, Imranul +16 more
core +1 more source
Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives
EFSA Journal, Volume 22, Issue 11, November 2024.Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF) +42 more
wiley +1 more source
FASEB BioAdvances, Volume 6, Issue 9, Page 327-336, September 2024.In humans, paragangliomas (PGLs) form in certain neuroendocrine cells that have lost succinate dehydrogenase, an enzyme of the tricarboxylic acid cycle. Conditional SDH deficiency has not yet been shown to drive PGL formation in mice, limiting available research tools. Here, prenatal SDH knockout in small numbers of SOX10+ precursors of adrenal medulla
Elizabeth P. Lewis +7 more
wiley +1 more source
Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts. [PDF]
, 1996 Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were ...
Azuma, H. +5 more
core +1 more source
Aging Cell, Volume 23, Issue 9, September 2024.We tested if the effects of metformin were context specific in skeletal muscle using a rat model (high‐capacity and low‐capacity runners: HCRs/LCRs) with a divide in intrinsic aerobic capacity. Metformin lowered mitochondrial respiration, but a washout of metformin resulted in a doubling of respiratory capacity in HCRs, with no effect in LCRs.
Matthew P. Bubak +14 more
wiley +1 more source
Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10 [PDF]
, 2007 The presence of blood pressure (BP) quantitative trait loci (QTL) on rat chromosome 10 has been clearly demonstrated by linkage analysis and substitution mapping.
Farms, Phyllis +6 more
core +1 more source
Experimental animals, 1999 Inbreeding for many generations under optimal environmental conditions may have favoured the survival of alleles for blood pressure increase in phenotypically normotensive rat strains.
J. van den Brandt +2 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, Volume 7, Issue 3, Page 297-309, June 2024.Abstract Diabetes mellitus is one of the world's most prevalent and complex metabolic disorders, and it is a rapidly growing global public health issue. It is characterized by hyperglycemia, a condition involving a high blood glucose level brought on by deficiencies in insulin secretion, decreased activity of insulin, or both.
Yasodha Krishna Janapati, Sunil Junapudi
wiley +1 more source