Identification of the genetic background of laboratory rats through amplicon-based next-generation sequencing for single-nucleotide polymorphism genotyping [PDF]
BMC Genomic DataBackground Laboratory rats, as model animals, have been extensively used in the fields of life science and medicine. It is crucial to routinely monitor the genetic background of laboratory rats. The conventional approach relies on gel electrophoresis and
Meng Lu, Kai Li, Yuxun Zhou, Junhua Xiao
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Superovulation with an anti-inhibin monoclonal antibody improves the reproductive performance of rat strains by increasing the pregnancy rate and the litter size [PDF]
Scientific ReportsRats are multiparous rodents that have been used extensively in research; however, the low reproductive performance of some rat strains hampers the broader use of rats as a biomedical model.
Keiji Mochida +7 more
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Shiyan dongwu yu bijiao yixue, 2023 Objective To establish a set of single nucleotide polymorphisms (SNP) detection protocol for inbred rats based on multiplex PCR-ligase detection reaction (LDR).Methods A total of 40 rats SNP sites were selected on chromosomes 1-20 and X of rats among 5 ...
ZHAO Liya +7 more
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A low coefficient of variation in hepatic triglyceride concentration in an inbred rat strain
Lipids in Health and Disease, 2020 Background Inbred strains are characterized by less genetic variation, which suggests usefulness of inbred strains for evaluations of various parameters.
Tomoko Shimoda +8 more
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Simulated childbirth injuries in an inbred rat strain [PDF]
Neurourology and Urodynamics, 2008 AbstractAimsVaginal distension (VD) in outbred rats has been shown to decrease urethral resistance, as well as increase the expression of the stem cell‐homing chemokine, monocyte chemotactic factor 3 (MCP‐3), but not stromal derived factor 1 (SDF‐1). The aim of this study was to determine if similar responses are induced by VD in an inbred rat strain ...
Hui Q. Pan +5 more
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Strain differences in delay discounting using inbred rats [PDF]
Genes, Brain and Behavior, 2009 A heightened aversion to delayed rewards is associated with substance abuse and numerous other neuropsychiatric disorders. Many of these disorders are heritable, raising the possibility that delay aversion may also have a significant genetic or heritable component.
Clare J. Wilhelm, Suzanne H. Mitchell
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Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
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Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat. [PDF]
PLoS ONE, 2014 The plasma profile of major lipoprotein classes and its subdivision into particular fractions plays a crucial role in the pathogenesis of atherosclerosis and is a major predictor of coronary artery disease. Our aim was to identify genomic determinants of
Miloslava Hodúlová +9 more
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Traffic Noise Exposure Increases Gastric Acid Secretion in Rat [PDF]
Acta Medica Iranica, 2010 Noise is considered as one of the most severe sources of environmental and work place constraints. Noise effects on immune function, hormonal levels, cardiovascular and respiratory systems are well known.
Azam Moslehi +5 more
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The genetic component of the forced diving bradycardia response in mammals
Frontiers in Physiology, 2011 We contrasted the forced diving bradycardia between two genetically similar (inbred) rat strains (Fischer and Buffalo), compared to that of outbred rats (Wistar). The animals were habituated to forced diving for 4 weeks.
Andreas eFahlman +3 more
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