Inhalation of 1-bromopropane alters hippocampal expression of pathways related to immune system/inflammation and insulin signaling in experimental rats [PDF]
Scientific Reports1-Bromopropane, an alternative to ozone-depleting solvents, exhibits neurotoxicity in humans and rats. The aim of the present study was to identify the genes or signaling pathways involved in the neurotoxicity and hepatotoxicity of 1-bomopropane in two ...
Fen Huang +12 more
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Identification of the genetic background of laboratory rats through amplicon-based next-generation sequencing for single-nucleotide polymorphism genotyping [PDF]
BMC Genomic DataBackground Laboratory rats, as model animals, have been extensively used in the fields of life science and medicine. It is crucial to routinely monitor the genetic background of laboratory rats. The conventional approach relies on gel electrophoresis and
Meng Lu, Kai Li, Yuxun Zhou, Junhua Xiao
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Shiyan dongwu yu bijiao yixue, 2023 Objective To establish a set of single nucleotide polymorphisms (SNP) detection protocol for inbred rats based on multiplex PCR-ligase detection reaction (LDR).Methods A total of 40 rats SNP sites were selected on chromosomes 1-20 and X of rats among 5 ...
ZHAO Liya +7 more
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A low coefficient of variation in hepatic triglyceride concentration in an inbred rat strain
Lipids in Health and Disease, 2020 Background Inbred strains are characterized by less genetic variation, which suggests usefulness of inbred strains for evaluations of various parameters.
Tomoko Shimoda +8 more
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Strain differences in delay discounting using inbred rats [PDF]
Genes, Brain and Behavior, 2009 A heightened aversion to delayed rewards is associated with substance abuse and numerous other neuropsychiatric disorders. Many of these disorders are heritable, raising the possibility that delay aversion may also have a significant genetic or heritable component.
C J, Wilhelm, S H, Mitchell
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Simulated childbirth injuries in an inbred rat strain [PDF]
Neurourology and Urodynamics, 2008 AbstractAimsVaginal distension (VD) in outbred rats has been shown to decrease urethral resistance, as well as increase the expression of the stem cell‐homing chemokine, monocyte chemotactic factor 3 (MCP‐3), but not stromal derived factor 1 (SDF‐1). The aim of this study was to determine if similar responses are induced by VD in an inbred rat strain ...
Lynn L, Woo +5 more
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Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
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Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]
, 2002 Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R. +4 more
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Shear Stress Is Differentially Regulated Among Inbred Rat Strains [PDF]
Circulation Research, 2003 An important compensatory response to atherosclerosis is vascular remodeling, with maintenance of vessel lumen diameter and shear stress. Both hemodynamic and environmental factors contribute to vascular remodeling and shear stress regulation, and the process is probably also influenced by genetic factors.
Jamila, Ibrahim +2 more
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Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat. [PDF]
PLoS ONE, 2014 The plasma profile of major lipoprotein classes and its subdivision into particular fractions plays a crucial role in the pathogenesis of atherosclerosis and is a major predictor of coronary artery disease. Our aim was to identify genomic determinants of
Miloslava Hodúlová +9 more
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