Results 41 to 50 of about 50,502 (212)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice

BMC Genetics, 2012
Background The genetic architecture of complex traits strongly influences the consequences of inherited mutations, genetic engineering, environmental and genetic perturbations, and natural and artificial selection.
Spiezio Sabrina H, Takada Toyoyuki, Shiroishi Toshihiko, Nadeau Joseph H   +3 more
doaj   +1 more source

Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats

Particle and Fibre Toxicology, 2020
Background Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive.
Astrid Skovmand, Aaron Erdely, James M. Antonini, Timothy R. Nurkiewicz, Mohammad Shoeb, Tracy Eye, Vamsi Kodali, Katrin Loeschner, Janja Vidmar, Jørgen S. Agerholm, Sandra Goericke-Pesch, Ulla Vogel, Karin S. Hougaard   +12 more
doaj   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Identification of the genetic background of laboratory rats through amplicon-based next-generation sequencing for single-nucleotide polymorphism genotyping

BMC Genomic Data
Background Laboratory rats, as model animals, have been extensively used in the fields of life science and medicine. It is crucial to routinely monitor the genetic background of laboratory rats. The conventional approach relies on gel electrophoresis and
Meng Lu, Kai Li, Yuxun Zhou, Junhua Xiao
doaj   +1 more source

Microbiome‐mediated plant‐soil feedbacks as a tool for resilient agriculture

iMetaOmics, EarlyView.
Translating plant‐soil feedbacks (PSFs) into reliable agricultural management requires shifting from input‐dependent practices toward endogenous, process‐driven crop resilience. To bridge this gap, we propose a predictive framework centered on three strategic interventions: engineering the crop holobiont, diversifying the soil habitat, and deploying ...
Muhammad Asif, Hazrat Bilal, Min Xiao, Lei Dong, Wen‐Jun Li   +4 more
wiley   +1 more source

Impairment of object recognition, object location and spatial working memory performance in inbred RHA vs. RLA rats

Frontiers in Behavioral Neuroscience
The inbred Roman rat strains, which have been selected and bred for their very high (RHA) or extremely poor (RLA) ability to acquire the two-way active avoidance task, constitute a bidirectional genetic model in which each strain differs from the other ...
Toni Cañete, Daniel Sampedro-Viana, Geison Souza Izídio, Berta Baró, Ignasi Oliveras, Cristóbal Río-Álamos, Margalida Coll-Andreu, Adolf Tobeña, Alberto Fernández-Teruel   +8 more
doaj   +1 more source

Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency.

PLoS Genetics, 2019
Recent evidence implicates mononuclear diploid cardiomyocytes as a proliferative and regenerative subpopulation of the postnatal heart. The number of these cardiomyocytes is a complex trait showing substantial natural variation among inbred mouse strains
Peiheng Gan, Michaela Patterson, Alexa Velasquez, Kristy Wang, Di Tian, Jolene J Windle, Ge Tao, Daniel P Judge, Takako Makita, Thomas J Park, Henry M Sucov   +10 more
doaj   +1 more source

A rat model of early stage osteonecrosis induced by glucocorticoids

Journal of Orthopaedic Surgery and Research, 2011
Background Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated.
Kerachian Mohammad, Harvey Edward J, Cournoyer Denis, Chow Terry Y, Nahal Ayoub, Séguin Chantal   +5 more
doaj   +1 more source

Adapting Genotyping-by-Sequencing and Variant Calling for Heterogeneous Stock Rats

G3: Genes, Genomes, Genetics, 2020
The heterogeneous stock (HS) is an outbred rat population derived from eight inbred rat strains. HS rats are ideally suited for genome wide association studies; however, only a few genotyping microarrays have ever been designed for rats and none of them ...
Alexander F. Gileta, Jianjun Gao, Apurva S. Chitre, Hannah V. Bimschleger, Celine L. St. Pierre, Shyam Gopalakrishnan, Abraham A. Palmer   +6 more
doaj   +1 more source