Results 61 to 70 of about 50,502 (212)

Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution.

PLoS ONE, 2016
Over the past half century, thousands of quantitative trait loci (QTL) have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle ...
Lishi Wang, Yan Jiao, Yongjun Wang, Mengchen Zhang, Weikuan Gu   +4 more
doaj   +1 more source

Genetic Background Influences Acute Response to TBI in Kindling-Susceptible, Kindling-Resistant, and Outbred Rats

Frontiers in Neurology, 2020
We hypothesized that the acute response to traumatic brain injury (TBI) shares mechanisms with brain plasticity in the kindling model. Utilizing two unique, complementary strains of inbred rats, selected to be either susceptible or resistant to seizure ...
Robert J. Kotloski, Robert J. Kotloski, Paul A. Rutecki, Paul A. Rutecki, Thomas P. Sutula   +4 more
doaj   +1 more source

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.

PLoS ONE, 2009
The second to fourth digit ratio (2Dratio4D) is sexually differentiated in a variety of species, including humans, rats, birds, and lizards. In humans, this ratio tends to be lower in males than in females.
Reginia H Y Yan, Mark Bunning, Douglas Wahlsten, Peter L Hurd   +3 more
doaj   +1 more source

Using liquid chromatography mass spectrometry (LC-MS) to assess the effect of age, high-fat diet, and rat strain on the liver metabolome.

PLoS ONE, 2020
The goal of this study was to use liquid chromatography mass spectrometry to assess metabolic changes of two different diets in three distinct rat strains.
Greg Boyce, Mohammad Shoeb, Vamsi Kodali, Terence Meighan, Jenny R Roberts, Aaron Erdely, Michael Kashon, James M Antonini   +7 more
doaj   +1 more source

Do Habitat Restoration Efforts and the Associated Releases of Hatchery‐Reared Fish Affect the Genetic Diversity and Integrity of Native Brown Trout Populations?

Fisheries Management and Ecology, EarlyView.
ABSTRACT Habitat restoration may protect brown trout (Salmo trutta) populations from loss of genetic diversity by increasing environmental carrying capacity and, consequently, population size. However, the accompanying release of hatchery‐reared fish may threaten the genetic integrity of native populations through introgression.
Noor Alwash, Ari Huusko, Tuomas Leinonen, Teppo Vehanen, Aki Mäki‐Petäys, Giovanna Mottola, Anssi Vainikka   +6 more
wiley   +1 more source

The power of a stewardship mind: Reorienting organizations around the duty to care to better address grand challenges

International Journal of Management Reviews, EarlyView.
Abstract The present article presents an integrative review related to stewardship in all the business and management disciplines, from its initial development in 1980 to the present. Specifically, we applied a latent Dirichlet allocation‐based topic modelling analysis to almost 1200 articles, seeking to creatively synthesize the concept of stewardship
Debora Casoli, Marco Visentin, Annamaria Tuan, Giuseppe Cappiello   +3 more
wiley   +1 more source

Mitochondrial DNA phylogeography of the Norway rat.

PLoS ONE, 2014
Central Eastern Asia, foremost the area bordering northern China and Mongolia, has been thought to be the geographic region where Norway rats (Rattus norvegicus) have originated.
Ying Song, Zhenjiang Lan, Michael H Kohn
doaj   +1 more source

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, EarlyView.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source

ZmMS1 coordinates ROS homeostasis, lipid allocation, and male fertility for maize breeding applications

Journal of Integrative Plant Biology, EarlyView.
The redox‐sensitive transcriptional repressor ZmMS1 coordinates reactive oxygen species homeostasis and lipid allocation for pollen exine and anther cuticle formation. Loss or precocious expression of ZmMS1 causes male sterility. Constitutive overexpression induces dwarfism and semi‐sterility. These findings enable flexible maize male‐sterility systems
Quancan Hou, Xueli An, Zhenying Dong, Biao Ma, Suowei Wu, Ke Xie, Ziwen Li, Tingwei Yan, Yilin Jiang, Taotao Zhu, Bin Ma, Lina Zhao, Yan Long, Xiangyuan Wan   +13 more
wiley   +1 more source