Results 71 to 80 of about 50,671 (216)

New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein

Disease Models & Mechanisms, 2016
The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome, respectively.
Ana Isabel Garcia Diaz, Ben Moyon, Philip M. Coan, Neza Alfazema, Lara Venda, Kevin Woollard, Tim Aitman   +6 more
doaj   +1 more source

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, EarlyView.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source

ZmMS1 coordinates ROS homeostasis, lipid allocation, and male fertility for maize breeding applications

Journal of Integrative Plant Biology, EarlyView.
The redox‐sensitive transcriptional repressor ZmMS1 coordinates reactive oxygen species homeostasis and lipid allocation for pollen exine and anther cuticle formation. Loss or precocious expression of ZmMS1 causes male sterility. Constitutive overexpression induces dwarfism and semi‐sterility. These findings enable flexible maize male‐sterility systems
Quancan Hou, Xueli An, Zhenying Dong, Biao Ma, Suowei Wu, Ke Xie, Ziwen Li, Tingwei Yan, Yilin Jiang, Taotao Zhu, Bin Ma, Lina Zhao, Yan Long, Xiangyuan Wan   +13 more
wiley   +1 more source

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat.

PLoS ONE, 2019
Sex-based differences in susceptibility have been reported for a number of neovascular ocular diseases. We quantified corneal neovascularization, induced by superficial silver nitrate cautery, in male and female inbred albino Sprague-Dawley, inbred ...
Yazad D Irani, Emily Pulford, Lauren Mortimer, Swati Irani, Lisa Butler, Sonja Klebe, Keryn A Williams   +6 more
doaj   +1 more source

Phenotypic plasticity is broadly adaptive across an elevation gradient in the Cutleaf Monkeyflower

New Phytologist, EarlyView.
Leaf shape plasticity expression is variable in Mimulus laciniatus. Summary Phenotypic plasticity is a key mechanism by which organisms cope with environmental heterogeneity, but its evolutionary consequences depend on how plastic responses align with the broader adaptive landscape.
Jill M. Love, Kathleen G. Ferris
wiley   +1 more source

BEHAVIOR OF RAT NEONATES WITH INHERITED STRESS-INDUCED ARTERIAL HYPERTENSION

Вавиловский журнал генетики и селекции, 2015
The present work concerns the development of locomotor activity, rates of weight gain, vibrissa growth, and time of eyelid opening in two inbred rate strains in the early development.
I. O. Meshkov, T. A. Alekhina, T. A. Moreva   +2 more
doaj  

Chemically Induced Oncogenesis in the Peripheral Nervous System Is Suppressed in Congenic BDIX.BDIV-Mss1 and -Mss7 Rats

G3: Genes, Genomes, Genetics, 2016
Human malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas with a poor prognosis that arise either in the context of neurofibromatosis 1 or sporadically.
Bernd Koelsch, Linda van den Berg, Christine Fischer, Bettina Winzen-Reichert, Andrea Kutritz, Andrea Kindler-Röhrborn   +5 more
doaj   +1 more source

Strain-Dependent Differences in Oxygen-Induced Retinopathy in the Inbred Rat

Investigative Opthalmology & Visual Science, 2005
To examine the susceptibilities of different rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity.Litters of newborn rats of five inbred strains (Fischer 344 [F344], Dark Agouti [DA], Sprague-Dawley [SD], Wistar-Furth [WF], Lewis [LEW]) and one outbred strain (Hooded Wistar [HW]) were maintained in room air or were ...
van Wijngaarden, Peter, Coster, Douglas John, Brereton, Helen Mary, Gibbins, Ian Lewis, Williams, Keryn Anne   +4 more
openaire   +3 more sources

The combination of morphogenic regulators BABY BOOM and GRF‐GIF improves maize transformation efficiency and promotes leaf regeneration

New Phytologist, EarlyView.
Maize regeneration via somatic embryogenesis by ectopic expression of morphogenic factors TaGRF4‐TaGIF1 and ZmBBM. Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic ...
Zongliang Chen, Jiaqi Zhou, Mary Galli, Sessen Daniel Iohannes, Theresa Clark, Juan M. Debernardi, Jorge Dubcovsky, David Jackson, Andrea Gallavotti   +8 more
wiley   +1 more source

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

G3: Genes, Genomes, Genetics, 2016
To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (
Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier   +12 more
doaj   +1 more source