Results 91 to 100 of about 130,261 (276)

Genetic Background Influences Acute Response to TBI in Kindling-Susceptible, Kindling-Resistant, and Outbred Rats

Frontiers in Neurology, 2020
We hypothesized that the acute response to traumatic brain injury (TBI) shares mechanisms with brain plasticity in the kindling model. Utilizing two unique, complementary strains of inbred rats, selected to be either susceptible or resistant to seizure ...
Robert J. Kotloski, Robert J. Kotloski, Paul A. Rutecki, Paul A. Rutecki, Thomas P. Sutula   +4 more
doaj   +1 more source

Placentophagia in Nonpregnant Nulliparous Mice: A Genetic Investigation [PDF]

, 1975
The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALB/cBy and C57BL/6By), their F1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the
Eleftheriou, Basil E., Kristal, Dr. Mark B.   +1 more
core   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.

PLoS ONE, 2009
The second to fourth digit ratio (2Dratio4D) is sexually differentiated in a variety of species, including humans, rats, birds, and lizards. In humans, this ratio tends to be lower in males than in females.
Reginia H Y Yan, Mark Bunning, Douglas Wahlsten, Peter L Hurd   +3 more
doaj   +1 more source

Using liquid chromatography mass spectrometry (LC-MS) to assess the effect of age, high-fat diet, and rat strain on the liver metabolome.

PLoS ONE, 2020
The goal of this study was to use liquid chromatography mass spectrometry to assess metabolic changes of two different diets in three distinct rat strains.
Greg Boyce, Mohammad Shoeb, Vamsi Kodali, Terence Meighan, Jenny R Roberts, Aaron Erdely, Michael Kashon, James M Antonini   +7 more
doaj   +1 more source

Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. [PDF]

, 2013
It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are due to both genetic and environmental factors. Animal studies provide important translational models for elucidating specific genetic or environmental factors ...
Ashwood, P, Berman, RF, Careaga, M, Onore, CE, Rushakoff, JA, Schwartzer, JJ   +5 more
core   +2 more sources

Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats

Epilepsia, EarlyView.
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley   +1 more source

Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD [PDF]

, 2016
Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently ...
Bardo, M. T., Dwoskin, L. P., Kantak, K. M., Somkuwar, S. S.   +3 more
core   +1 more source

The power of a stewardship mind: Reorienting organizations around the duty to care to better address grand challenges

International Journal of Management Reviews, EarlyView.
Abstract The present article presents an integrative review related to stewardship in all the business and management disciplines, from its initial development in 1980 to the present. Specifically, we applied a latent Dirichlet allocation‐based topic modelling analysis to almost 1200 articles, seeking to creatively synthesize the concept of stewardship
Debora Casoli, Marco Visentin, Annamaria Tuan, Giuseppe Cappiello   +3 more
wiley   +1 more source

Mitochondrial DNA phylogeography of the Norway rat.

PLoS ONE, 2014
Central Eastern Asia, foremost the area bordering northern China and Mongolia, has been thought to be the geographic region where Norway rats (Rattus norvegicus) have originated.
Ying Song, Zhenjiang Lan, Michael H Kohn
doaj   +1 more source