Results 101 to 110 of about 68,662 (250)

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, EarlyView.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source

New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein

Disease Models & Mechanisms, 2016
The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome, respectively.
Ana Isabel Garcia Diaz, Ben Moyon, Philip M. Coan, Neza Alfazema, Lara Venda, Kevin Woollard, Tim Aitman   +6 more
doaj   +1 more source

Changes in renal WT-1 expression preceding hypertension development [PDF]

, 2016
Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica, Calvo, Juan Pablo, Casarotto, Mariana, Cuello Carrión, Fernando Darío, Ferder, León, Fornes, Miguel Walter, García, Isabel Mercedes, Manucha, Walter Ariel Fernando, Mazzei, Luciana Jorgelina   +8 more
core   +2 more sources

PanGraphRNA: An efficient and flexible bioinformatics platform for graph pangenome‐based RNA‐seq data analysis

Journal of Integrative Plant Biology, EarlyView.
PanGraphRNA is an easy‐to‐use platform that improves RNA‐seq analysis by using graph pangenomes instead of a single reference genome. It increases read alignment accuracy, detects important genes missed by traditional methods, and works across major crops, helping researchers obtain more reliable transcriptome results for diverse plant research and ...
Yifan Bu, Zhixu Qiu, Wen Sun, Yishui Han, Yifan Liu, Jing Yang, Minggui Song, Zenglin Li, Songyu Liu, Yuzhou Zhang, Chuang Ma   +10 more
wiley   +1 more source

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat.

PLoS ONE, 2019
Sex-based differences in susceptibility have been reported for a number of neovascular ocular diseases. We quantified corneal neovascularization, induced by superficial silver nitrate cautery, in male and female inbred albino Sprague-Dawley, inbred ...
Yazad D Irani, Emily Pulford, Lauren Mortimer, Swati Irani, Lisa Butler, Sonja Klebe, Keryn A Williams   +6 more
doaj   +1 more source

From QTL to candidate gene: a genetic approach to alcoholism research [PDF]

, 2009
A major focus of research in alcohol-related disorders is to identify the genes and pathways that modulate alcohol-seeking behavior. In light of this, animal models have been established to study various aspects of alcohol dependence.
Carr, Lucinda G., Foroud, Tatiana, Johnson, Philip L., Liang, Tiebing, Liu, Lixiang, Shekhar, Anantha, Spence, John P.   +6 more
core   +1 more source

Arabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia

New Phytologist, EarlyView.
Summary Acclimation enables plants to adjust to immediate environmental fluctuations and is therefore key to the resilience of plant disease resistance in a time of climate change. Here, we report on the acclimation of Arabidopsis thaliana quantitative immune responses against the fungal pathogen Sclerotinia sclerotiorum to daily environmental ...
Marie Didelon, Justine Sucher, Florent Delplace, Pedro Carvalho‐Silva, Matilda Zaffuto, Adelin Barbacci, Sylvain Raffaele   +6 more
wiley   +1 more source

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. [PDF]

, 2016
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Avetisyan, Rozeta, Gong, Ke Wei, Lusis, Aldons J, Rau, Christoph, Ren, Shuxun, Romay, Milagros C, Stolin, Gabriel, Wang, Jessica Jen-Chu, Wang, Yibin   +8 more
core   +3 more sources

AhBWR15, A Novel RLK Gene, Confers Resistance to Ralstonia solanacearum in Peanut

Plant Biotechnology Journal, EarlyView.
ABSTRACT Bacterial wilt (BW), a severe soil‐borne disease caused by Ralstonia solanacearum, significantly impedes global peanut production. Despite its impact, the mechanisms underlying BW resistance in peanut remain unclear. Herein, we selected the highly resistant variety Nongdahua108 (H108) and the susceptible variety Nongdahua107 (H107) to develop ...
Zenghui Cao, Kai Zhao, Hao Li, Xingli Ma, Di Cao, Yanzhe Li, Sasa Hu, Qian Ma, Yaoyao Li, Yi Fan, Mengtian Hou, Kunkun Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Rui Ren, Dongmei Yin   +16 more
wiley   +1 more source

BEHAVIOR OF RAT NEONATES WITH INHERITED STRESS-INDUCED ARTERIAL HYPERTENSION

Вавиловский журнал генетики и селекции, 2015
The present work concerns the development of locomotor activity, rates of weight gain, vibrissa growth, and time of eyelid opening in two inbred rate strains in the early development.
I. O. Meshkov, T. A. Alekhina, T. A. Moreva   +2 more
doaj