Results 101 to 110 of about 49,631 (197)

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, Volume 25, Issue 1, January 2026.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Pharmacotherapy Risks in Rare Genetic Diseases: Cross‐Referencing ACMG Secondary Findings v3.2 List With Clinical Databases

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Clinical genomics and pharmacogenomics have largely remained separate fields, though some genetic variants have overlapping disease risk and drug implications. However, the extent of this overlap is not well studied. To explore this gap, we cross‐referenced genes from the American College of Medical Genetics Secondary Findings v3.2 list with ...
Josiah D. Allen, Benjamin Q. Duong, Jordan Brady, Pamela Arn   +3 more
wiley   +1 more source

Density Dependence During Evolutionary Rescue Increases Extinction Risk but Does Not Prevent Adaptation

Ecology Letters, Volume 29, Issue 1, January 2026.
This study investigates how density dependence influences evolutionary rescue in populations facing environmental stress. We found that while density dependence increases extinction risk by limiting population growth, it does not prevent adaptation in surviving populations.
Laure Olazcuaga, Brett A. Melbourne, Scott W. Nordstrom, Ruth A. Hufbauer   +3 more
wiley   +1 more source

AIRE's Complex Role Beyond Promiscuous Gene Expression

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Central tolerance, established in the thymus, ensures T cells are nonreactive to self‐antigens while maintaining a functional immune repertoire. Medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) play a crucial role in this mechanism by orchestrating the selection and deletion of autoreactive thymocytes, a process ...
Pärt Peterson
wiley   +1 more source

OsSAE1 orchestrates the antagonistical regulation of gibberellin and abscisic acid signaling to control rice seed germination

Journal of Integrative Plant Biology, Volume 68, Issue 1, Page 203-219, January 2026.
The AP2 transcription factor SALT AND ABA RESPONSE ERF 1 (OsSAE1) acts as a key regulator in improving rice seed germination rate. OsSAE1 precisely controls the homeostasis of abscisic acid and gibberellin in seeds, and provides a target for breeding rice varieties that are suitable for direct seeding.
Dinglin Xiao, Yuxiang Li, Bingkun Ge, Zihan Zhao, Zhiheng Suo, Juan Wang, Chunxia Yan, Zhi Qi, Rongfeng Huang, Ruidang Quan, Hua Qin   +10 more
wiley   +1 more source

Global Warming Affects the Pathogenesis of Important Fish Diseases in European Aquaculture

Reviews in Aquaculture, Volume 18, Issue 1, January 2026.
The effect of global warming on pathogens and their fish hosts that could exacerbate the negative outcomes for aquaculture. Changes in farming practices and the development of innovative mitigation tools may prove essential to cope with the effects and impacts of rising water temperatures on fish diseases in Europe.
George Rigos, Francesc Padrós, Maria Constenla, Ana Jerončić, Dimitra Kogiannou, Sofia Consuegra, Mikolaj Adamek, Ivona Mladineo   +7 more
wiley   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

The Journal of Physiology, Volume 604, Issue 1, Page 297-316, 1 January 2026.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht, Benjamin E. Loflin, Adam R. Carter, Roufael Hanna, Simran Shergill, Edward M. Wojtys   +5 more
wiley   +1 more source

Shortcoming of the Mouse Model of Postoperative Ileus: Small Intestinal Lengths Have Similar Variations in In- and Outbred Mice and Cannot Be Predicted by Allometric Parameters. [PDF]

Biomedicines
von Stumberg M, Akinci E, Ertim B, Oetzmann von Sochaczewski C.   +3 more
europepmc   +1 more source

Regional differences in the distribution of melanocyte-containing hair bulbs in the skin of male albino rats. [PDF]

PLoS One
Numata N, Ozawa A, Sakaue M.
europepmc   +1 more source

Hi-C sequencing data from frontal cortex of laboratory rats. [PDF]

Sci Data
Kim P, Ward RR, Sharp BM, Williams RW, Chen H.   +4 more
europepmc   +1 more source