Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review. [PDF]
Alcohol Clin Exp Res (Hoboken)In this narrative review, we identify barriers to the translation of preclinical comorbidity models of alcohol use disorder and depressive disorders, including temporal and pharmacological discrepancies. In humans, depression is high during and immediately after the cessation of drinking and usually remits subsequently, while in animals it seems to ...
Winkler GA, Grahame NJ.
europepmc +2 more sources
Epilepsia Open, EarlyView., 2022 Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza +7 more
wiley +1 more source
Candidate Anxiety-Related Genes in the Hippocampus of Hatano Male Rats: Anxiolytic Action of Neuromedin U in the Hippocampus. [PDF]
Neuropsychopharmacol RepWe screened for gene candidates in the hippocampus related to anxiety using Hatano high avoidance animals (HAA) and low avoidance animals (LAA), inbred rat strains that exhibit high and low levels of anxiety‐like behavior. The microarray analysis revealed differences in 498 gene expressions between HAA and LAA, of which nine genes conducted RT‐qPCR ...
Sato K +11 more
europepmc +2 more sources
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Lifespan modulation in mice and the confounding effects of genetic background [PDF]
, 2014 We are currently in the midst of a revolution in ageing research, with several dietary, genetic and pharmacological interventions now known to modulate ageing in model organisms.
Mulvey, Lorna +2 more
core +1 more source
Strain-dependent variations in stress coping behavior are mediated by a 5-HT/GABA interaction within the prefrontal corticolimbic system [PDF]
, 2015 Background: Serotonin and γ- Aminobutyric acid (GABA) transmission is crucial in coping strategies. Methods: Here, using mice from 2 inbred strains widely exploited in behavioral neurochemistry, we investigated whether serotonin transmission in medial ...
ANDOLINA, DIEGO +3 more
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Behavioral Profiles of Genetically Selected Aggressive and Nonaggressive Male Wild House Mice in Two Anxiety Tests [PDF]
, 2000 Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light–dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for ...
Hof, Maleen, +6 more
core +6 more sources
QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains [PDF]
, 2009 Peer reviewedPublisher ...
Blizard, David A +6 more
core +3 more sources
Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]
, 2015 Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M. +5 more
core +1 more source