Results 31 to 40 of about 68,662 (250)

1st INCF Workshop on Genetic Animal Models for Brain Diseases [PDF]

, 2011
The INCF Secretariat organized a workshop to focus on the “role of neuroinformatics in the processes of building, evaluating, and using genetic animal models for brain diseases” in Stockholm, December 13–14, 2009.
Holm Graessner, Olaf Riess
core   +2 more sources

Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations. [PDF]

PLoS ONE, 2012
Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes.
Eneda Pjetri, Ria de Haas, Simone de Jong, Cigdem Gelegen, Hugo Oppelaar, Linda A W Verhagen, Marinus J C Eijkemans, Roger A Adan, Berend Olivier, Martien J Kas   +9 more
doaj   +1 more source

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse [PDF]

, 2004
Fragile X Syndrome is the most common form of\ud inherited mental retardation. It is also known for having\ud a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always\ud caused by inactivation of the
Bauchwitz, Dr. Robert P.
core   +1 more source

Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor

Behavioral and Brain Functions, 2007
Rodents are known to display fear-related responses when exposed to the odor of natural predators, such as cats, even when they are totally naïve to these stimuli.
Ramos André, Vendruscolo Leandro F, Brüske Gustavo R   +2 more
doaj   +1 more source

Dysfunctional play and dopamine physiology in the Fischer 344 rat

, 2011
Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain.
Akopian, Akopian, Akopian, Alcaro, Alessandri, Almeida, Baldwin, Bamford, Basar, Beatty, Beatty, Bell, Berridge, Breier, Broderick, Burgdorf, Burgdorf, Burghardt, Burghardt, Burghardt, Cadoni, Cadoni, Calabresi, Chambers, Cheng, Cordier, Crawford, Crawley, Cynthia A. Crawford, Davis, Depoortere, Fagen, Feifel, Field, Fleckenstein, Gainetdinov, Garnik Akopian, Garris, Geyer, Glowa, Gomez-Serrano, Gonon, Gordon, Guitart, Gulley, Guo, Gurden, Hariri, Harris, Helmeste, Huang, Huang, Hubbard, Humphries, Ikemoto, John P. Walsh, Kerr, Knutson, Kolomiets, Kosten, Leblois, Leipold, McGraw La, Meaney, Miles, Niesink, Panksepp, Panksepp, Panksepp, Panksepp, Panksepp, Patel, Patel, Pellegrini, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Pellis, Petzinger, Pliszka, Reif, Robinson, Romeo, Sagvolden, Schulte, Sills, Siviy, Siviy, Siviy, Siviy, Siviy, Siviy, Skuse, Smith, Smith, Spear, Spinka, Stamford, Stephen M. Siviy, Stohr, Sulzer, Surmeier, Swerdlow, Swerdlow, Swerdlow, Tang, Terranova, Trezza, Trezza, Trezza, Trezza, Tripp, Van den Berg, Vanderschuren, Vanderschuren, Vanderschuren, Varty, Villar, Volkow, Voorn, Walker, Young   +126 more
core   +1 more source

Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels following Exposure to Proton Radiation Are Related to Basal Dopaminergic Function.

PLoS ONE, 2015
The current report assessed the effects of low-level proton irradiation in inbred adult male Fischer 344 and Lewis rats performing an analog of the human Psychomotor Vigilance Test (PVT), commonly utilized as an object risk assessment tool to quantify ...
Catherine M Davis, Kathleen L DeCicco-Skinner, Robert D Hienz   +2 more
doaj   +1 more source

Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]

, 2017
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC, Bina Joe, Biron P, Biron P, Bright R, Cook HW, Dublin LI, Dublin LI, Dupont J, Esunge PM, Felts JH, Garrod AE, Garrod AE, Garrod AE, Hamilton M, Hamilton M, Hamilton M, Joe B, Koffler M, Korner PI, Kuijpers MH, Lee YH, Lewis O, Markel’ AL, Matsukawa N, Mo R, Ohno Y, Pickering GW, Pravenec M, Sandosh Padmanabhan, Schlager G, Shear CL, Shiozawa M, Smolarek I, Zhang Y   +34 more
core   +1 more source

Strain specific effects of low level lead exposure on associative learning and memory in rats. [PDF]

, 2017
Exposure to lead (Pb) remains a significant public health concern. Lead exposure in early life impairs the normal development of numerous cognitive and neurobehavioral processes.
Schneider, J. S., Verma, Megha
core   +2 more sources

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source