Results 41 to 50 of about 53,463 (191)

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Strain restricted typing sera for the use in the genetic monitoring of inbred strains of mice and rats from two danish SPF breeders [PDF]

, 1992
Strain restricted typing sera (SRTS) were produced for some of the most used inbred mouse and rat strains in Denmark by injecting lymphocytes pooled from several different strains intraperitoneally into the recipients.
Dagnaes-Hansen, Frederik, Hansen, Axel Kornerup, Jensen, Lene   +2 more
core   +3 more sources

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

The Genetic Component of the Forced Diving Bradycardia Response in Mammals [PDF]

, 2011
We contrasted the forced diving bradycardia between two genetically similar (inbred) rat strains (Fischer and Buffalo), compared to that of outbred rats (Wistar). The animals were habituated to forced diving for 4 weeks.
Bostrom, Brian L., Dillon, Kiran H., Fahlman, Andreas, Jones, David R.   +3 more
core   +3 more sources

The Impact of Brain‐Derived Neurotrophic Factor rs6265 (Val66Met) Polymorphism on Therapeutic Electrical Stimulation for Peripheral Nerve Regeneration: A Preclinical Study of Therapy–Genotype Interactions

Muscle &Nerve, EarlyView.
The rs6265 (Val66Met) BDNF SNP determines responsiveness to a clinically relevant therapeutic electrical stimulation (TES) protocol following peripheral nerve injury. This study examined gene–treatment interactions using a rat model of sciatic nerve injury and human iPSC‐derived motor neurons to assess how the common rs6265 BDNF polymorphism influences
Jordan B. Walters, Maria J. Quezada, Suning He, Ciara S. Haynes, Kathy Steece‐Collier, Timothy J. Collier, Caryl E. Sortwell, Colin K. Franz   +7 more
wiley   +1 more source

Successful islet allotransplantation in diabetic rats immunosuppressed with FK506: A functional and immunological study [PDF]

, 1994
The effect of a novel immunosuppressive agent, FK506, on fresh islet allografts was evaluated in diabetic rats across major histocompatibility complex (MHC) barriers with respect to the transplantation (TR) site, islet source, treatment regimen, and ...
Cheung, SSC, Murase, N, Starzl, TE, Tai, J, Tze, WJ   +4 more
core   +1 more source

Muffled olfactory and sensory cues from the reproductive stage soybean selectively reduce oviposition of a major polyphagous herbivore, fall armyworm (Spodoptera frugiperda)

Pest Management Science, EarlyView.
Fall armyworm (FAW) preferred ovipositing on vegetative‐stage soybeans. While ‘mother knows best’ may not apply in soybean‐FAW system, muffled cues in the reproductive stage could positively influence host success. Abstract BACKGROUND While the mother knows best/preference performance hypothesis has been well tested in natural ecosystems, how these ...
Krishnarao Gandham, Manish Gautam, Justin George, Gadi V.P. Reddy, Rupesh Kariyat   +4 more
wiley   +1 more source

Effects of Aging on Glucose and Lipid Metabolism in Mice

Aging Cell, Volume 24, Issue 4, April 2025.
Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit evidence of upregulated fatty acid and sphingolipid metabolism reactions that regenerate NAD+ from NADH.
Evan C. Lien, Ngoc Vu, Anna M. Westermark, Laura V. Danai, Allison N. Lau, Yetiş Gültekin, Matthew A. Kukurugya, Bryson D. Bennett, Matthew G. Vander Heiden   +8 more
wiley   +1 more source

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

Aging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud   +9 more
wiley   +1 more source