Results 41 to 50 of about 97,044 (222)

Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice

BMC Genetics, 2012
Background The genetic architecture of complex traits strongly influences the consequences of inherited mutations, genetic engineering, environmental and genetic perturbations, and natural and artificial selection.
Spiezio Sabrina H, Takada Toyoyuki, Shiroishi Toshihiko, Nadeau Joseph H   +3 more
doaj   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

A rat model of early stage osteonecrosis induced by glucocorticoids

Journal of Orthopaedic Surgery and Research, 2011
Background Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated.
Kerachian Mohammad, Harvey Edward J, Cournoyer Denis, Chow Terry Y, Nahal Ayoub, Séguin Chantal   +5 more
doaj   +1 more source

Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats

Particle and Fibre Toxicology, 2020
Background Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive.
Astrid Skovmand, Aaron Erdely, James M. Antonini, Timothy R. Nurkiewicz, Mohammad Shoeb, Tracy Eye, Vamsi Kodali, Katrin Loeschner, Janja Vidmar, Jørgen S. Agerholm, Sandra Goericke-Pesch, Ulla Vogel, Karin S. Hougaard   +12 more
doaj   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency.

PLoS Genetics, 2019
Recent evidence implicates mononuclear diploid cardiomyocytes as a proliferative and regenerative subpopulation of the postnatal heart. The number of these cardiomyocytes is a complex trait showing substantial natural variation among inbred mouse strains
Peiheng Gan, Michaela Patterson, Alexa Velasquez, Kristy Wang, Di Tian, Jolene J Windle, Ge Tao, Daniel P Judge, Takako Makita, Thomas J Park, Henry M Sucov   +10 more
doaj   +1 more source

Adapting Genotyping-by-Sequencing and Variant Calling for Heterogeneous Stock Rats

G3: Genes, Genomes, Genetics, 2020
The heterogeneous stock (HS) is an outbred rat population derived from eight inbred rat strains. HS rats are ideally suited for genome wide association studies; however, only a few genotyping microarrays have ever been designed for rats and none of them ...
Alexander F. Gileta, Jianjun Gao, Apurva S. Chitre, Hannah V. Bimschleger, Celine L. St. Pierre, Shyam Gopalakrishnan, Abraham A. Palmer   +6 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Shear Stress Is Differentially Regulated Among Inbred Rat Strains [PDF]

Circulation Research, 2003
An important compensatory response to atherosclerosis is vascular remodeling, with maintenance of vessel lumen diameter and shear stress. Both hemodynamic and environmental factors contribute to vascular remodeling and shear stress regulation, and the process is probably also influenced by genetic factors.
Jody K. Miyashiro, Bradford C. Berk, Jamila Ibrahim   +2 more
openaire   +3 more sources

Enhancing sudden unexpected death in epilepsy (SUDEP) research through development of common data elements

Epilepsia Open, EarlyView.
Abstract Objective Sudden Unexpected Death in Epilepsy (SUDEP) is a fatal complication for individuals living with epilepsy and is associated with significant personal and public burden. While certain neurotransmitters and neuronal pathways have been associated with SUDEP, the exact biological mechanisms are unknown.
Sloka S. Iyengar, Elaine K. O'Loughlin, Lauren Harte‐Hargrove, Mary Holmay, Laura S. Lubbers, CURE Epilepsy SUDEP Data Standardization Project Steering Committee, CURE Epilepsy SUDEP Data Standardization Project Working Group Members, Lisa M. Bateman, Edward Glasscock, Samden Lhatoo, Philippe Ryvlin, Kristina Simeone, Charles Akos Szabo, Melanie Whittamore‐Mantzios, David Auerbach, Gordon Buchanan, Jeffrey Buchhalter, Beate Diehl, Elizabeth Donner, Carl Faingold, Daniel Friedman, Christina Gross, Bin Gu, Franck Kalume, David Ryan King, Nuria Lecumberri, Susanne Mueller, William Nobis, Jeffrey Noebels, Terence O’Brien, Manoj Patel, George Richerson, Steven Schachter, Timothy Simeone, Ian Wenker   +34 more
wiley   +1 more source