Results 1 to 10 of about 23,392 (148)

Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence of salt-loading [PDF]

Nutrition & Metabolism, 2010
Background There are safety concerns regarding widespread consumption of phytosterol and phytostanol supplemented food products. The aim of this study was to determine, in the absence of excess dietary salt, the individual effects of excess accumulation ...
Ratnayake Walisundera MN, Pakenham Catherine, Coville Kara, Swist Eleonora, Gruber Heidi, Chen Qixuan, Scoggan Kylie A   +6 more
doaj   +4 more sources

Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity

Scientific Reports, 2021
The WMI and WLI inbred rats were generated from the stress-prone, and not yet fully inbred, Wistar Kyoto (WKY) strain. These were selected using bi-directional selection for immobility in the forced swim test and were then sib-mated for over 38 ...
Tristan V. de Jong, Panjun Kim, Victor Guryev, Megan K. Mulligan, Robert W. Williams, Eva E. Redei, Hao Chen   +6 more
doaj   +2 more sources

Influence of dietary phytosterols and phytostanols on diastolic blood pressure and the expression of blood pressure regulatory genes in SHRSP and WKY inbred rats [PDF]

British Journal of Nutrition, 2008
The aim of the present study was to determine the impact of increased consumption of phytosterols or phytostanols on blood pressure and renal blood pressure regulatory gene expression in stroke-prone spontaneously hypertensive (SHRSP) and normotensive Wistar–Kyoto (WKY) inbred rats. SHRSP and WKY inbred rats (10/group) were fed a control diet or a diet
Qixuan, Chen, Heidi, Gruber, Eleonora, Swist, Catherine, Pakenham, Walisundera M N, Ratnayake, Kylie A, Scoggan   +5 more
openaire   +3 more sources

A missense mutation in the Abcg5 gene causes phytosterolemia in SHR, stroke-prone SHR, and WKY rats Published, JLR Papers in Press, March 1, 2003. DOI 10.1194/jlr.M200438-JLR200

Journal of Lipid Research, 2003
Sitosterolemia is an autosomal recessive disorder caused by mutations in the ABCG5 or ABCG8 half-transporter genes. These mutations disrupt the mechanism that distinguishes between absorbed sterols and is most prominently characterized by hyperabsorption
Kylie A. Scoggan, Heidi Gruber, Katherine Larivière   +2 more
doaj   +2 more sources

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet

Disease Models & Mechanisms, 2016
Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are ...
Neus Martínez-Micaelo, Noemi González-Abuín, Ximena Terra, Ana Ardévol, Montserrat Pinent, Enrico Petretto, Jacques Behmoaras, Mayte Blay   +7 more
doaj   +2 more sources

Graft arteriosclerosis develops spontaneously after heart transplant in “inbred” wistar-kyoto (WKY) and spontaneously hypertensive (SHR) rats

Journal of the American College of Cardiology, 1990
Smith, Vivienne-E., Qian, Shiguang, Cramer, Donald V.   +2 more
openaire   +2 more sources

WKY/Ztm-ter: a new rat inbred strain on the WKY/Ztm genetic background with congenital teratomas [PDF]

Laboratory Animals, 2004
We describe a new rat model for teratomas (WKY/Ztm- ter) which arose through a spontaneous mutation in the inbred WKY/Ztm rat strain. When the tumours of the gonads became clinically apparent, affected males were 14 to 224 days of age, whereas the females only developed tumours between days 21 and 63. Tumour incidence is not gender-dependent. However,
B, Länger, M, Dorsch, K, Gärtner, D, Wedekind, K, Kamino, H J, Hedrich   +5 more
openaire   +2 more sources

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2010
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Somkuwar, Sucharita S., Kantak, Kathleen M., Dwoskin, Linda P.   +2 more
core   +4 more sources

Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]

, 2017
Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy, Dashti, Mohammed, Dominiczak, Anna F., Graham, Delyth, Koh-Tan, H.H. Caline, McBride, Martin W., Mcclure, John, Wang, Ting, Young, Barbara   +8 more
core   +7 more sources

Whole genome sequencing of nearly isogeneic WMI and WLI inbred rats identifies genes potentially involved in depression

bioRxiv, 2020
Background The WMI and WLI inbred rat substrains were generated from the stress-prone, and not yet fully inbred, Wistar Kyoto (WKY) strain using bi-directional selection for immobility in the forced swim test followed by over 38 generations of inbreeding.
Tristan de Jong, Panjun Kim, V. Guryev, Megan K. Mulligan, Robert W. Williams, E. Redei, Hao Chen   +6 more
semanticscholar   +1 more source