Results 11 to 20 of about 3,076 (133)

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet [PDF]

Disease Models & Mechanisms, 2016
Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are ...
Neus Martínez-Micaelo, Noemi González-Abuín, Ximena Terra, Ana Ardévol, Montserrat Pinent, Enrico Petretto, Jacques Behmoaras, Mayte Blay   +7 more
doaj   +2 more sources

Nociception and conditioned fear in rats: strains matter.

PLoS ONE, 2013
When using rats in pain research, strain-related differences in outcomes of tests for pain and nociception are acknowledged. However, very little is known about the specific characteristics of these strain differences. In this study four phylogenetically
Manon W H Schaap, Hugo van Oostrom, Arie Doornenbal, José van 't Klooster, Annemarie M Baars, Saskia S Arndt, Ludo J Hellebrekers   +6 more
doaj   +2 more sources

New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein [PDF]

Disease Models & Mechanisms, 2016
The Wistar Kyoto (WKY) rat and the spontaneously hypertensive (SHR) rat inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome, respectively.
Ana Isabel Garcia Diaz, Ben Moyon, Philip M. Coan, Neza Alfazema, Lara Venda, Kevin Woollard, Tim Aitman   +6 more
doaj   +2 more sources

Effects of early life trauma are dependent on genetic predisposition: a rat study

Behavioral and Brain Functions, 2011
Background Trauma experienced early in life increases the risk of developing a number of psychological and/or behavioural disorders. It is unclear, however, how genetic predisposition to a behavioural disorder, such as attention-deficit/hyperactivity ...
Russell Vivienne A, Howells Fleur M, Sterley Toni-Lee   +2 more
doaj   +2 more sources

Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains [PDF]

, 2009
Background Cognitive function might be affected by the subjects' emotional reactivity. We assessed whether behavior in different tests of emotional reactivity is correlated with performance in aversively motivated learning tasks, using four strains of ...
Korte S Mechiel, Schuurman Teun, Korte, S.M., Sub BasicPharmacology&Psychopharmacology, Staay, F.J., van der, van Reenen, C.G., van der Staay F Josef, van der Staay, F.J., Cornelis G van Reenen, Schuurman, T., Reenen, C.G., van, Dep Gezondheidszorg Landbouwhuisdieren, F Josef van der Staay, van Reenen Cornelis G, Emotion and Cognition, S Mechiel Korte, Dierexperimenteel, Teun Schuurman   +17 more
core   +1 more source

Absence of warm-up during active avoidance learning in a rat model of anxiety vulnerability: Insights from computational modeling

Frontiers in Behavioral Neuroscience, 2014
Avoidance behaviors, in which a learned response causes omission of an upcoming punisher, are a core feature of many psychiatric disorders. While reinforcement learning (RL) models have been widely used to study the development of appetitive behaviors ...
Catherine E Myers, Catherine E Myers, Ian M. Smith, Richard J Servatius, Richard J Servatius, Kevin D. Beck, Kevin D. Beck   +6 more
doaj   +1 more source

Can Wistar rats be used as the normotensive controls for nerve morphometry investigations in spontaneously hypertensive rats (SHR)? Ratos Wistar podem ser utilizados como os controles normotensos dos ratos espontaneamente hipertensos (SHR) em investigações morfométricas de nervos periféricos?

Acta Cirúrgica Brasileira, 2011
PURPOSE: We compared the sural nerve morphology among Wistar (WR), Wistar-Kyoto (WKY) and Spontaneously hypertensive (SHR) rats, including the nerve fascicles and myelinated fibers morphometry.
Luciana Sayuri Sanada, Marcelo Rodrigo Tavares, Milena Cardoso Maia Neubern, Helio Cesar Salgado, Valéria Paula Sassoli Fazan   +4 more
doaj   +1 more source

Strain differences in baroceptor reflex in adult Wistar Kyoto rats

Clinics, 2010
OBJECTIVES: A subset of normotensive Sprague-Dawley rats show lower baroreflex sensitivity; however, no previous study investigated whether there are differences in baroreflex sensitivity within this subset.
Vitor E. Valenti, Luiz Carlos de Abreu, Caio Imaizumi, Márcio Petenusso, Celso Ferreira   +4 more
doaj   +1 more source

Influence of arterial hypertension on colonic healing in rats Influência da hipertensão arterial na cicatrização colônica em ratos

Acta Cirúrgica Brasileira, 2012
PURPOSE: Evaluation of colonic healing in spontaneously hypertensive rats. METHODS: Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group.
Gilberto Luiz Ortolan, Maria de Lourdes Pessole Biondo-Simões, Giovani Marino Fávero, Daniel Fernandes, Mário Rodrigues Montemór Netto, Luiz Renato Olchanheski Jr   +5 more
doaj   +1 more source

Genetic Model to Study the Co-Morbid Phenotypes of Increased Alcohol Intake and Prior Stress-Induced Enhanced Fear Memory

Frontiers in Genetics, 2018
Posttraumatic Stress Disorder (PTSD) is a complex illness, frequently co-morbid with depression, caused by both genetics, and the environment. Alcohol Use Disorder (AUD), which also co-occurs with depression, is often co-morbid with PTSD.
Patrick Henry Lim, Guang Shi, Tengfei Wang, Sophia T. Jenz, Megan K. Mulligan, Eva E. Redei, Hao Chen   +6 more
doaj   +1 more source