Results 11 to 20 of about 717,881 (139)

Characterization of myocardium, isolated cardiomyocytes, and blood pressure in WKHA and WKY rats

, 2002
We previously reported that the left ventricular (LV) mass of Wistar-Kyoto (WKY)-derived hyperactive (WKHA) rats was higher than that of WKY rats in the absence of a difference in systolic blood pressure.
Touyz, R.M., Rouleau, J., Thibault, G., Deschepper, C.F., Picard, S.   +4 more
core   +8 more sources

Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life. [PDF]

Neuropsychopharmacol Rep
Expression of the VIP/PACAP receptor gene, Vipr2, was selectively upregulated in the nucleus accumbens of spontaneous hypertensive rats (SHRs), an animal model of ADHD, with no changes observed in DNA methylation levels at the CpG islands of the gene. This region‐specific overexpression may contribute to ADHD‐related behaviors in SHRs.
Araki R, Kita A, Ago Y, Yabe T.
europepmc   +2 more sources

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats. [PDF]

Aging Cell
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Biswas S, Nguyen HVM, Converse A, Matsuzaki S, Kinter MT, Humphries KM, Freeman WM, Ocañas SR, Richardson A, Duncan FE, Lewis TL, Stout MB.   +11 more
europepmc   +2 more sources

Chronic mild stress induces sustained-activation of p38 MAPK signaling in the female WKY rats with endogenous depression [PDF]

, 2023
Stress is a major precipitant of depression, the hippocampus (HPC) and prefrontal cortex (PFC) is the main structures affected by depressive disorders. Women are twice more likely to experience depression than men.
Dronjak, Slađana, Janković, Milica, Virijević, Kristina, Spasojević, Nataša, Stefanović, Bojana, Ferizović, Harisa   +5 more
core   +6 more sources

Shaping the development of complex social behavior

Annals of the New York Academy of Sciences, Volume 1530, Issue 1, Page 46-63, December 2023., 2023
Abstract Early life experiences can have an enduring impact on the brain and behavior, with implications for stress reactivity, cognition, and social behavior. In particular, the neural systems that contribute to the expression of social behavior are altered by early life social environments.
James P. Curley, Frances A. Champagne
wiley   +1 more source

Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats [PDF]

, 2009
<p><b>Background and Purpose:</b> Stroke-prone spontaneously hypertensive rats (SHRSP) are a highly pertinent stroke model with increased sensitivity to focal ischemia compared with the normotensive reference strain (Wistar-Kyoto rats ...
Dominiczak, Anna F., Graham, Delyth, Macrae, I. Mhairi, Gallagher, Lindsay, Gsell, Willy, McCabe, Christopher   +5 more
core   +1 more source

Animal models for anti‐neutrophil cytoplasmic antibody‐associated vasculitis: Are current models good enough?

Animal Models and Experimental Medicine, Volume 6, Issue 5, Page 452-463, October 2023., 2023
The construction of the most representative AAV animal models that are used as powerful tools for investigating disease pathogenesis and testing pre‐clinical therapeutics. (A) The representative active MPO‐AAV model, Enhanced EAV rat model by NTS trigger. (B) The representative passive MPO‐AAV model, Anti MPO ANCA transfer model. (C) The representative
Fei Huang, Yongman Lv, Siyang Liu, Hao Wu, Qingquan Liu   +4 more
wiley   +1 more source

Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways

The Journal of Pathology, Volume 257, Issue 3, Page 300-313, July 2022., 2022
Abstract P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)‐1β ...
Maria Prendecki, Stephen P McAdoo, Tabitha Turner‐Stokes, Ana Garcia‐Diaz, Isabel Orriss, Kevin J Woollard, Jacques Behmoaras, H Terence Cook, Robert Unwin, Charles D Pusey, Timothy J Aitman, Frederick WK Tam   +11 more
wiley   +1 more source

Innate lymphoid cell characterization in the rat and their correlation to gut commensal microbes

European Journal of Immunology, Volume 52, Issue 5, Page 717-729, May 2022., 2022
Rat ILCs are here defined and characterized across multiple tissues, and we have defined the borders between rat NK cells and ILC1s via scRNA‐Seq. Variations of intestinal ILC frequencies in individual rats were mapped against composition of the commensal microbiota. Abstract Innate lymphoid cells (ILCs) are important for tissue immune homeostasis, and
Amanda Sudworth, Filip M. Segers, Bahtiyar Yilmaz, Naomi C. Guslund, Andrew J. Macpherson, Erik Dissen, Shuo‐Wang Qiao, Marit Inngjerdingen   +7 more
wiley   +1 more source

Impact of the Aversive Effects of Drugs on Their Use and Abuse

Behavioural Neurology, Volume 2022, Issue 1, 2022., 2022
Drug use and abuse are complex issues in that the basis of each may involve different determinants and consequences, and the transition from one to the other may be equally multifaceted. A recent model of the addiction cycle (as proposed by Koob and his colleagues) illustrates how drug‐taking patterns transition from impulsive (acute use) to compulsive
Anthony L. Riley, Hayley N. Manke, Shihui Huang, Andrew Huang   +3 more
wiley   +1 more source