Results 21 to 30 of about 23,411 (167)

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

A long non‐coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats

Genes, Brain and Behavior, Volume 20, Issue 2, February 2021., 2021
Lrap, a novel lncRNA, is a mediator of alcohol consumption and a modifier of brain RNA expression and splicing. Categories from GO and KEGG pathways that are enriched within the group of differentially expressed transcripts in brains of the Lrap +/+ versus Lrap −/− rats (A).
Laura M. Saba, Paula L. Hoffman, Gregg E. Homanics, Spencer Mahaffey, Swapna Vidhur Daulatabad, Sarath Chandra Janga, Boris Tabakoff   +6 more
wiley   +1 more source

Lifestyle‐Induced Redox‐Sensitive Alterations: Cross‐Talk among the RAAS, Antioxidant/Inflammatory Status, and Hypertension

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
The development and progression of hypertension are closely linked to an unhealthy lifestyle; however, its underlying mechanisms are not fully elucidated. Our aim was to assess the effects of diet and exercise on the elements of the renin–angiotensin–aldosterone system (RAAS), redox‐sensitive parameters, and the expression of the vascular tone ...
Renáta Szabó, Denise Börzsei, Alexandra Hoffmann, Zelma Nadin Lesi, Rudolf Gesztelyi, Béla Juhász, Gábor J. Szebeni, Jasmin Osman, Judith Sebestyén, Arnold Nagy, Sándor Szegedi, Csaba Varga, Anikó Pósa, Simon Lees   +13 more
wiley   +1 more source

Avoidance as expectancy in rats: Sex and strain differences in acquisition

Frontiers in Behavioral Neuroscience, 2014
Avoidance is a core feature of anxiety disorders and factors which increase avoidance expression or its resistance represent a source of vulnerability for anxiety disorders. Outbred female Sprague Dawley (SD) rats and inbred male and female Wistar-Kyoto (
Pelin eAvcu, Pelin eAvcu, Xilu eJiao, Xilu eJiao, Catherine E. Myers, Catherine E. Myers, Catherine E. Myers, Catherine E. Myers, Kevin D. Beck, Kevin D. Beck, Kevin D. Beck, Kevin D. Beck, Kevin C. H. Pang, Kevin C. H. Pang, Kevin C. H. Pang, Kevin C. H. Pang, Richard J. Servatius, Richard J. Servatius, Richard J. Servatius, Richard J. Servatius   +19 more
doaj   +1 more source

Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder

Frontiers in Integrative Neuroscience, 2018
Aside from its clinical symptoms of inattention, impulsivity and hyperactivity, patients with Attention/Deficit-Hyperactivity Disorder (ADHD) display reward and motivational impairments. These impairments may reflect a deficit in action control, that is,
Joman Y. Natsheh, Joman Y. Natsheh, Joman Y. Natsheh, Joman Y. Natsheh, Michael W. Shiflett   +4 more
doaj   +1 more source

Changes in renal WT-1 expression preceding hypertension development [PDF]

, 2016
Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica, Calvo, Juan Pablo, Casarotto, Mariana, Cuello Carrión, Fernando Darío, Ferder, León, Fornes, Miguel Walter, García, Isabel Mercedes, Manucha, Walter Ariel Fernando, Mazzei, Luciana Jorgelina   +8 more
core   +2 more sources

Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD [PDF]

, 2016
Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently ...
Bardo, M. T., Dwoskin, L. P., Kantak, K. M., Somkuwar, S. S.   +3 more
core   +1 more source

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Absence of warm-up during active avoidance learning in a rat model of anxiety vulnerability: Insights from computational modeling

Frontiers in Behavioral Neuroscience, 2014
Avoidance behaviors, in which a learned response causes omission of an upcoming punisher, are a core feature of many psychiatric disorders. While reinforcement learning (RL) models have been widely used to study the development of appetitive behaviors ...
Catherine E Myers, Catherine E Myers, Ian M. Smith, Richard J Servatius, Richard J Servatius, Kevin D. Beck, Kevin D. Beck   +6 more
doaj   +1 more source

Necessity for research directed at stimulant type and treatment-onset age to access the impact of medication on drug abuse vulnerability in teenagers with ADHD [PDF]

, 2016
Controversy continues regarding increased vulnerability for addiction to cocaine and other drugs of abuse in adulthood following the use of stimulant medications for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
Dwoskin, Linda P., Kantak, Kathleen M.
core   +1 more source