Results 161 to 170 of about 905,086 (195)

Prostate cancer in a Sprague‐Dawley rat

The Prostate, 1985
AbstractAn adenocarcinoma of the prostate gland developed in one rat of the Lobund Sprague‐Dawley (S‐D) strain, following treatments with testosterone propionate in silastic membranes. The transplanted cells (PA‐SD1) developed local tumors, metastasized through lymphatic channels to the lungs, and induced osteolytic lesions when deposited adjacent to ...
M, Pollard, P H, Luckert
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Leiomyoma of the iris in a Sprague-Dawley rat

Journal of Comparative Pathology, 1987
A leiomyoma of the iris was composed of bundles of spindle-shaped cells with abundant myoglial fibres and represents the first observation of this rare tumour in a rat.
R A, Owen, P, Duprat
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Postirradiation Sarcomas in Sprague-Dawley Rats

Radiation Research, 1998
A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co gamma rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in
P T, Tinkey, T M, Lembo, G R, Evans, J H, Cundiff, K N, Gray, R E, Price   +5 more
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Spontaneous Hibernomas in Sprague-Dawley Rats

Toxicologic Pathology, 2009
Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals. Background incidence values for these tumors in all common strains of laboratory rats are generally accepted as being <0.1%.
Richard H, Bruner, Meliton N, Novilla, Catherine A, Picut, Jeannie B, Kirkpatrick, Thomas P, O'Neill, Kathryn L, Scully, Wade B, Lawrence, Dawn G, Goodman, Brett H, Saladino, David G, Peters, George A, Parker   +10 more
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Behavioral heterogeneity in Sprague-Dawley rats

Physiology & Behavior, 1992
Because of consistent individual differences in animal behavior, it is often difficult to interpret experimental data. We therefore attempted to rank Sprague Dawley rats by a hierarchical ascendant clustering technique using data from avoidance conditioning and open-field testing (scores of exploratory activity before, during, and after an ...
M, Curé, J P, Rolinat
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Intrauterine Expression of Prothrombin in the Sprague-Dawley Rat

Journal of the Society for Gynecologic Investigation, 2002
Thrombin appears to underlie myometrial contractions in response to intrauterine bleeding. In a similar fashion, thrombin generated within the uterus in the absence of active bleeding could also produce contractions. These studies sought to determine whether functionally active prothrombin is expressed in the pregnant and nonpregnant rat uterus.
Mark, Phillippe, David, Wolff, Trevania, Saunders, Leandra, Thomas, Jeffrey, Chapa   +4 more
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Spontaneous leukaemia in a sprague-dawley rat

Experientia, 1962
Description d'un cas de chloroleucemie myeloide chez un rat de souche Sprague-Dawley, presentant quelques modifications peu communes des tubes renaux.
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Disposition of butadiene epoxides in Sprague-Dawley rats

Chemico-Biological Interactions, 1997
1,2-Epoxybutene (BMO) and diepoxybutane (BDE) are metabolic products of 1,3-butadiene in rodents. Both BMO and BDE are suspect in the development of tumors in rats and mice. To understand the distribution and elimination of these compounds in the absence of the rate-limiting production from butadiene, the pharmacokinetics of BMO and BDE in blood were ...
J L, Valentine, P J, Boogaard, L M, Sweeney, M J, Turner, J A, Bond, M A, Medinsky   +5 more
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Spontaneous endocrine tumors in Sprague-Dawley rats

Journal of Cancer Research and Clinical Oncology, 1979
Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas ...
H, Suzuki, U, Mohr, G, Kimmerle
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Toxicity Studies of Epichlorohydrin in Sprague-Dawley Rats

Drug and Chemical Toxicology, 1996
Adult male and female Sprague-Dawley rats received epichlorohydrin via gavage in distilled water for 10 consecutive days at dose levels of 3, 7, 19, and 46 mg/kg-day, and for 90 days at dose levels of 1, 5, and 25 mg/kg-day. Epichlorohydrin did not adversely effect mortality, but toxicity, at the higher doses, was evident by: 1) losses in body weight ...
F B, Daniel, M, Robinson, G R, Olson, N P, Page   +3 more
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