Results 181 to 190 of about 427,760 (358)

Tumor‐Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion

Advanced Science, EarlyView.
This study identifies Globo H ceramide (GHCer) as a novel immune checkpoint molecule that suppresses the activation of conventional T lymphocytes while promoting the differentiation and function of regulatory T cells. The immunosuppressive effects of GHCer are mediated through the activation of the A2AR/cAMP/PKA pathway, which involves its interactions
Jing‐Yan Cheng, Hsiu‐Hui Tsai, Jung‐Tung Hung, Tsai‐Hsien Hung, Chun‐Cheng Lin, Chien‐Wei Lee, Zi‐Chi Lo, Jing‐Rong Huang, Shih‐Pin Chiou, Yenlin Huang, Shih‐Hsiang Chen, Chun‐Nan Yeh, John Yu, Alice L. Yu   +13 more
wiley   +1 more source

Pharmacokinetic characteristics of Jinhong tablets in normal, chronic superficial gastritis and intestinal microbial disorder rats [PDF]

arXiv
Jinhong tablet (JHT), a traditional Chinese medicine made from four herbs, effectively treats chronic superficial gastritis (CSG) by soothing the liver, relieving depression, regulating qi, and promoting blood circulation. However, its pharmacokinetics are underexplored.
arxiv  

Microneedle Patch for In Situ Neutrophil Monitoring

Advanced Science, EarlyView.
An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu, Ruisi Cai, Tianao Xie, Sheng Zhao, Sarun Juengpanich, Win Topatana, Shijie Li, Jiasheng Cao, Jiahao Hu, Tianen Chen, Jiachen Chen, Jicheng Yu, Tao Sheng, Wentao Zhang, Hao Wang, Jiahuan You, Yukai Shan, Yuchao Sun, Ruijing Shen, Zhengjie Zhao, Kangfan Ji, Ziqi Gao, Xinmin Yu, Xiujun Cai, Zhen Gu, Yuqi Zhang, Mingyu Chen   +26 more
wiley   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats

Middle East Fertility Society Journal, 2018
Background: Several studies have demonstrated Cisplatin-induced toxicity on the ovary. However, there is a dearth of literature on the effect of Cisplatin on the non-gravid uterus.
Izuchukwu Azuka Okafor, Stella Chinwe Gbotolorun   +1 more
doaj  

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery

Advanced Science, EarlyView.
A high‐strength pH‐responsive hydrogel‐forming microneedle integrates gradient solvent replacement to enhance the mechanical properties of the acrylonitrile‐acrylic acid copolymer network, ensuring robust transdermal penetration and long‐term drug release.
Hui Li, Fengzhen Meng, Chengwei Hu, Zhiyun Wu, Liuzhi Hao, Caijun Sun, Lijing Fang, Fan Pan, Shaoquan Bian, Huipeng Li, Mingjun Li, Bo Liu, Xiaoli Zhao   +12 more
wiley   +1 more source

Catabolism of chylomicron triacylglycerol and cholesteryl ester in genetically obese rats

Journal of Lipid Research, 1977
The catabolism of chylomicrons was investigated in genetically obese rats and their nonobese littermates, and was compared with catabolism in older Sprague–Dawley rats with body weights similar to the obese rats and their younger controls.
T G Redgrave
doaj  

Black Cumin Seed Oil Antidiabetogenic by Increasing Pancreatic P53 Expression [PDF]

, 2018
Black cumin seed oil (BCSO) contains many thymoquinone and unsaturated fatty acids that act as antioxidants. Thymoquinone was thought to inhibit pancreatic damage and prevent hyperglycemia by involving p53. The study aimed to determine the BCSO effect on
Akrom, A. (Akrom), Darmawan, E. (Endang), Hidayati, T. (Titiek), Nurfadjrin, R. (Rizma)   +3 more
core   +1 more source