Results 191 to 200 of about 427,760 (358)

Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Advanced Science, EarlyView.
A novel biodegradable wound dressing (E‐PCLs) based on polycaprolactone (PCL) and an enzyme complex (RHP‐BCL) is developed using a fiber microfluidic electrospinning technique. The dressing achieves complete degradation within 14 days, eliminates microplastic residues, and promotes scar‐free healing (99% in 21 days).
Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen   +7 more
wiley   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation

Advanced Science, EarlyView.
A hybrid nanogenerator (H‐NG) has been developed to be applied in epidural electrical stimulation (EES). Compared with a commercial stimulus generator (SG), the H‐NG can elicit hindlimb locomotion in rats with much lower electrical parameters and much smaller individual differences.
Cong Li, Yizhu Shan, Shihao Zheng, Puchuan Tan, Yuan Bai, Engui Wang, Lingling Xu, Ruizeng Luo, Shengyu Chao, Jing Huang, Pengyu Ren, Zhou Li, Hongqing Feng   +12 more
wiley   +1 more source

EFFECT OF SMOKING IN INTERLEKIN-6 IN SPRAGUE DAWLEY RATS

Pakistan Armed Forces Medical Journal, 2018
Objective: To investigate the effect of cigarette smoking on interleukin-6 in Sprague Dawley rats. Study Design: Randomized controlled study. Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan to Apr 2015 ...
Aneela Jamil, Amir Rashid, Abdul Khaliq Naveed   +2 more
doaj  

Naringenin attenuates highly active antiretroviral therapy‐induced sperm DNA fragmentations and testicular toxicity in Sprague‐Dawley rats

Andrology, 2018
M. Adana, M. Adana, E. N. Akang, E. N. Akang, Aniekan I. Peter, Aniekan I. Peter, A. I. Jegede, E. Naidu, C. Tiloke, Anil A. Chuturgoon, O. Azu   +10 more
semanticscholar   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

Advanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang, Leilei Yang, Jing jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li   +8 more
wiley   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang, Chang Shu, Chengwei Xu, Xingjie Zan, Shaoyin Wei, Chenglong Wang, Lianxin Li   +6 more
wiley   +1 more source

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

Advanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu   +3 more
wiley   +1 more source

RAT: Adversarial Attacks on Deep Reinforcement Agents for Targeted Behaviors [PDF]

arXiv
Evaluating deep reinforcement learning (DRL) agents against targeted behavior attacks is critical for assessing their robustness. These attacks aim to manipulate the victim into specific behaviors that align with the attacker's objectives, often bypassing traditional reward-based defenses.
arxiv  

ASSESSMENT OF SMOKE INDUCED GENOTOXICITY IN SPRAGUE DAWLEY RATS

Pakistan Armed Forces Medical Journal, 2019
Objective: To investigate the genotoxic effect of cigarette smoking in Sprague Dawley rats. Study Design: Randomized experimental study. Place and Duration of Study: Study was conducted at Army Medical College Rawalpindi, from Jan 2013 to Jul 2013.
Aneela Jamil, Amir Rashid, Abdul Khaliq Naveed   +2 more
doaj