Results 31 to 40 of about 448,712 (333)
Mathematical methods and models for radiation carcinogenesis studies [PDF]
, 1986 Research on radiation carcinogenesis requires a twofold approach. Studies of primary molecular lesions and subsequent cytogenetic changes are essential, but they cannot at present provide numerical estimates of the risk of small doses of ionizing ...
A.M. Kellerer +25 more
core +1 more source
Hematoxicity of amodiaquine in sprague-dawley rats
Toxicology International, 2012 The use of amodiaquine (AQ) and its associated toxic effect has been a major public health concern since cases of life-threatening agranulocytosis and hepatic toxicity were reported during its prophylactic use. The objective of this study was to evaluate the hematological safety profile of AQ therapy.Sprague-Dawley rats were randomly distributed into ...
Saka, W. A. +3 more
openaire +3 more sources
Improved timed-mating, non-invasive method using fewer unproven female rats with pregnancy validation via early body mass increases [PDF]
, 2018 For studies requiring accurate conception-timing, reliable, efficient methods of detecting oestrus reduce time and costs, whilst improving welfare. Standard methods use vaginal cytology to stage cycle, and breeders are paired–up using approximately five ...
Agata K Stramek +18 more
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Spontaneous Ocular Abnormalities in Sprague–Dawley Rats
Comparative Medicine, 2020 We collected historical control data derived from pretreatment ophthalmologic examinations of young (4 to 7 wk of age) Sprague–Dawley (Crl:CD[SD]) male, (2033, 42 lots) and female (1322, 32 lots) rats used in toxicity studies at our facility from 2004 through 2015.
Junya, Morita +4 more
openaire +3 more sources
bioRxiv, 2018 Sprague Dawley (SD) rats are among the most widely used outbred laboratory rat populations. Despite this, the genetic characteristics of SD rats have not been clearly described, and SD rats are rarely used for experiments aimed at exploring genotype ...
A. Gileta +12 more
semanticscholar +1 more source
Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats [PDF]
, 2018 Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus.
Cacao, Eliedonna +2 more
core +3 more sources
Journal of Veterinary Research, 2018 Introduction The study was designed to investigate the effects of repeated lipopolysaccharide (LPS) treatment on growth performance, lymphoid organ indexes, and blood cells in Sprague-Dawley rats.
Youbao Zhong +3 more
semanticscholar +1 more source
Strain specific effects of low level lead exposure on associative learning and memory in rats. [PDF]
, 2017 Exposure to lead (Pb) remains a significant public health concern. Lead exposure in early life impairs the normal development of numerous cognitive and neurobehavioral processes.
Schneider, J. S., Verma, Megha
core +2 more sources
Spontaneous Nephroblastoma in 3 Sprague-Dawley Rats
The Japanese Journal of Veterinary Science, 1982 SD系ラット3例に自然発生した腎臓腫瘍の病理組織学的検索を行った. 腫瘍は管を形成する一層の上皮性細胞と, その周囲に塊状に増殖する未分化な芽種性細胞から成り, 主に膠原線維から成る間質で分画されていた. この組織構築から腫瘍は腎芽腫と判断された. また, これらの上皮性細胞と芽種性細胞には電顕的に本質的な差を認めず, 組織構築が後腎胚種質に類似することと合わせ, 本腫瘍は腎実質上皮性の腫瘍であると考えられた.
T, Inui +4 more
openaire +3 more sources
Effect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats
JBRA Assisted Reproduction, 2017 Objective This study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats. Method A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (AD). Group
Benedict A. Falana +4 more
semanticscholar +1 more source