Results 51 to 60 of about 207,124 (265)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Atrioventricular Valvular Angiectasis in Sprague-Dawley Rats [PDF]

Veterinary Pathology, 2007
Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and in human fetuses and newborns. We observed a high incidence (62 in 208 animals examined) of spontaneous angiectasis on the atrioventricular (AV) valves in 10– to 40–week-old Sprague-Dawley rats. The angiectasis was observed predominately on the septal cusp of
H, Fang, P C, Howroyd, A M, Fletcher, R W, Diters, J, Woicke, V G, Sasseville, C L, Bregman, W J, Freebern, S K, Durham, M G, Mense   +9 more
openaire   +2 more sources

Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer

Acta Veterinaria, 2014
The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats.
Emília Hijová, Viktoria Szabadosova, Jana Štofilová, Rastislav Salaj, Alojz Bomba   +4 more
doaj   +1 more source

STUDY OF TOXICITY OF SAKHABACTISUBTIL IN RATS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2017
Aim. Determine safety and potential toxic effects of Sakhabactisubtil during its multifold intra-gastric administration to CD rats. Materials and methods.
M. P. Neustroev, A. N. Murashev, D. A. Bondarenko, A. M. Stepanova, N. P. Tarabukina   +4 more
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Polyorchidism in a young Sprague-Dawley rat

Journal of Toxicologic Pathology
Duplicate testes lined in series were observed in the right scrotum of a 6-week-old Sprague-Dawley rat in a single-dose toxicity study. Of the two right testicles, one was spherical and less than half the size of a normal testis. The other was oval-shaped, slightly smaller than a normal testis, and possessed clear, tortuous blood vessels similar to ...
Obara, Ryo D., Kato, Yuki, Asaoka, Yoshiji, Fujisawa, Kae, Kashiwagi, Emi, Koyama, Kenji, Mukai, Miho, Tajiri, Minako, Torii, Mikinori   +8 more
openaire   +2 more sources

Cutaneous Hybrid Cyst in a Sprague-Dawley Rat

Journal of Toxicologic Pathology, 2012
This report describes a spontaneous hybrid cyst in a Sprague-Dawley (SD) rat. A 52-week-old, male SD rat had a cutaneous cyst on the left mystacial pad. Histologically, the cyst wall showed infundibular differentiation with keratohyalin granules in the granular layer and matrical differentiation comprising basaloid epithelial cells with trichohyalin ...
Yasuno, Kyohei, Sakashita, Haruka, Araki, Saori, Kobayashi, Ryosuke, Sakurada, Yosuke, Shirota, Mariko, Kamiie, Junichi, Shirota, Kinji   +7 more
openaire   +3 more sources

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis

Acta Veterinaria, 2016
The effect of the probiotic strain Lactobacillus plantarum LS/07 on intestinal bacterial enzyme activities – β-glucuronidase (β-GLUCUR), β-galactosidase (β-GAL), and β-glucosidase (β-GLU) in the prevention of cancer, atherosclerosis and dysbiosis was ...
Hijová Emília, Kuzma Jozef, Strojný Ladislav, Bomba Alojz, Bertková Izabela, Chmelárová Anna, Hertelyová Zdena, Kuliková Lucia, Štofilová Jana, Ambro Ľuboš   +9 more
doaj   +1 more source

Resveratrol prevents cisplatin-induced lipid peroxidation in the non-gravid uterus of Sprague-Dawley rats

Middle East Fertility Society Journal, 2018
Background: Several studies have demonstrated Cisplatin-induced toxicity on the ovary. However, there is a dearth of literature on the effect of Cisplatin on the non-gravid uterus.
Izuchukwu Azuka Okafor, Stella Chinwe Gbotolorun   +1 more
doaj   +1 more source