Results 101 to 110 of about 852,599 (306)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. [PDF]

Neuroprotection
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Manavi MA, Salehi M, Mohammad Jafari R, Goudarzi R, Khosravi S, Dehpour AR.   +5 more
europepmc   +2 more sources

Virgin coconut oil reverses atrazine and diabetes-induced lipid profile derangements in male Wistar rats [PDF]

Aims: We assessed the ameliorative effect of virgin coconut oil (VCO) following atrazine (ATZ) and diabetes-induced lipid profile derangements in rats. Methods: Male Wistar rats (n=35) in the test group were divided into five groups (n=7): Groups 1, 2 ...
Stephanie Abiola Tijani, Daniel Ejike Eze, Jessica Utibe David, Helen Peter Udo, Asuquo Etim Asuquo, Jereton Ihoeghian Osaretin, Titilope Helen Olatunbosun, Ezekiel Etim Ben, Idorenyin Udo Umoren, Elemi John Ani   +9 more
core   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

The effect of the Tribulus terrestris extract on spermatogenesis in the rat [PDF]

فصلنامه دانشگاه علوم پزشکی جهرم, 2012
According to our antecedents, in addition to other pharmacological properties, Tribulus terrestris increases sexual functioning and libido in men. Due to the fact that the benefits of herbal drugs should be approved clinically in the laboratory, the ...
Hojatolah Karimi Jashni, Samira Malekzadeh Shiravani, Farhang Hooshmand   +2 more
doaj  

NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference

Frontiers in Psychiatry, 2019
Cocaine dependence is a psychiatric condition for which effective medications are still lacking. Published data indicate that an increase in nociceptin/orphanin FQ (N/OFQ) transmission by NOP receptor activation attenuates cocaine-induced place ...
Hongwu Li, Hongwu Li, Giulia Scuppa, Qianwei Shen, Alessio Masi, Cinzia Nasuti, Nazzareno Cannella, Roberto Ciccocioppo   +7 more
doaj   +1 more source

Corneal Mineralization in Wistar Hannover Rats

Journal of Toxicologic Pathology, 2013
We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ...
HASHIMOTO, Satomi, DOI, Takuya, WAKO, Yumi, SATO, Junko, WADA, Sou, TSUCHITANI, Minoru   +5 more
openaire   +3 more sources

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

An algorithm for seizure detection in rodents

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy animal research often relies on long‐term intracranial electroencephalographic (iEEG) recordings. Here, we describe an artificial neural network (ANN) algorithm for automatic detection of seizures. Methods The algorithm was trained on iEEG recordings of three mouse models of chronic epilepsy: (1) the pilocarpine model of ...
Lyna Kamintsky, Gerben van Hameren, Itai Weissberg, Pooyan Moradi, Ofer Prager, Alaa Abu Ahmad, Lior Schori, Albert Becker, Yaniv Zigel, Alon Friedman   +9 more
wiley   +1 more source

Effect of Wheat/Cassava Composite Bread on Liver Architecture of Wistar Rat

Journal of Pure and Applied Microbiology, 2018
This study reports the effect of different levels of wheat/cassava composite flour on liver architecture of wistar rat. The cassava variety- TMS 98/419 and Twenty (20) male wistar rats were used for the study.
M.O. Odo, P.A. Okorie, F. Azi , V.N. Nwobasi   +3 more
doaj   +1 more source