Results 131 to 140 of about 1,786,922 (333)

Gestational diabetes induces neuronal loss in dentate gyrus in rat offspring [PDF]

, 2014
Background: This study was conducted to determine the effect of gestational diabetes on neuronal density in the dentate gyrus (DG) subfields of hippocampus in rats offspring. Methods: On day 1 of gestation, 10 dams randomly allocated into two control and
Ghafari, S., Golalipour, M.J., Kafshgiri, S.K.   +2 more
core  

Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats [PDF]

, 2014
Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in ...
Ahima, ANDREIS, Arabi, Besedovsky, Blackwell, Bone, Bornstein, Carlson, Christopher D John, Clark, Connor, Costa, Csontos, Elenkov, Elmquist, GAILLARD, Heiman, Heuer, Hu, Huang, Jennifer A Parker, John, Julia C Buckingham, Kevin G Murphy, Kurt, Maffei, Mohn, Nishiyama, Ott, Pournajafi Nazarloo, Raber, Reyes, RIVIER, Rodr  guez-Wilhelmi, Saadia Basharat, Stephen R Bloom, Takao, Takemura, Vachharajani, Yousef, Zamorano   +40 more
core   +1 more source

Wistar rats: a forgotten model of age-related hearing loss

Frontiers in Aging Neuroscience, 2014
Age-related hearing loss (ARHL) is one of the most frequent sensory impairments in senescence and is a source of important socio-economic consequences.
J. Alvarado, V. Fuentes-Santamaría, M. C. Gabaldón-Ull, J. Blanco, J. Juiz   +4 more
semanticscholar   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

The effect of the Tribulus terrestris extract on spermatogenesis in the rat [PDF]

فصلنامه دانشگاه علوم پزشکی جهرم, 2012
According to our antecedents, in addition to other pharmacological properties, Tribulus terrestris increases sexual functioning and libido in men. Due to the fact that the benefits of herbal drugs should be approved clinically in the laboratory, the ...
Hojatolah Karimi Jashni, Samira Malekzadeh Shiravani, Farhang Hooshmand   +2 more
doaj  

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Avaliação da lesão isquêmica normotérmica do fígado: papel da oclusão do ducto biliar principal e da N-acetilcisteína

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Estudar o efeito da N-acetilcisteína (NAC) na isquemia hepática. MÉTODO: Trinta e oito ratos machos EPM-1 Wistar foram distribuídos em quatro grupos.
Susi Heliene Lauz Medeiros, Edna Frasson de Souza Montero, Lígia Ferreira Gomes, Murched Omar Taha, Virgínia Berlanga Campos Junqueira, Manuel de Jesus Simões   +5 more
doaj   +1 more source

NOP Receptor Agonist Ro 64-6198 Decreases Escalation of Cocaine Self-Administration in Rats Genetically Selected for Alcohol Preference

Frontiers in Psychiatry, 2019
Cocaine dependence is a psychiatric condition for which effective medications are still lacking. Published data indicate that an increase in nociceptin/orphanin FQ (N/OFQ) transmission by NOP receptor activation attenuates cocaine-induced place ...
Hongwu Li, Hongwu Li, Giulia Scuppa, Qianwei Shen, Alessio Masi, Cinzia Nasuti, Nazzareno Cannella, Roberto Ciccocioppo   +7 more
doaj   +1 more source