Results 131 to 140 of about 147,805 (240)

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Fructose consumption and metabolic hypertension in rats: a systematic review and meta-analysis. [PDF]

PeerJ
Vs A, Subramanian A, Rajendran K, Thamaraikani T, Kumarasamy V, Lian MS, Nordin RB, Sekar M, Subramaniyan V, Karnam M, Sackiriyas S, Wong LS.   +11 more
europepmc   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Sub-acute toxicity profiles of Rhoicissus tridentata as used in the traditional prostate cancer managment in the Elgon in Wistar albino rats. [PDF]

Sci Rep
Bbosa GS, Muwonge H, Lugaajju A, Wabinga H, Niyonzima N, Damani AM, Kafeero HM, Ssenku JE, Alemu SO, Lubowa M, Walusansa A, Sampath S, Kudamba A.   +12 more
europepmc   +1 more source

Injectable Biomimetic Composite Hydrogel Scaffold With Tissue‐Engineered Cartilage Matrix for Articular Cartilage Regeneration

Rare Metals, EarlyView.
ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu, Jun‐Jie Jiang, Hang Yao, Xian‐Feng Shang, Ming‐Di Zheng, Xu Hu, Shuo Xu, Jun‐Li Shi, Yan Han, Chi‐Run Wang, Qi Tao, Huai‐Guo Xue, Dong‐An Wang, Yu‐Chi Zhao   +13 more
wiley   +1 more source

Chronobiological analysis of sex differences in electrocardiographic parameters in spontaneously breathing Wistar rats under tiletamine-zolazepam anaesthesia. [PDF]

PLoS One
Novotná V, Grešová S, Švorc P.
europepmc   +1 more source

Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles

Small Methods, EarlyView.
Design of an injectable porous hydrogel modulating macrophages and their secreted EVs for joint defect repair in the pathology of rheumatoid arthritis. a) The solution containing HA and CS‐MOS, upon mixing with a crosslinker solution, undergoes porous hydrogel formation with the escape of generated CO₂ gas.
Anan Zhang, Yifan Ma, Yutong Liu, Shiyan Dong, Michelle Najarro Torres, Betty Y.S. Kim, Changsheng Liu, Lili Sun, Yuan Yuan, Wen Jiang   +9 more
wiley   +1 more source

Ecotoxicological Evaluation of the Antimicrobial Butylparaben in Edaphic Organisms Using Multiple Biomarkers

Environmental Toxicology, EarlyView.
ABSTRACT Butylparaben (BuP) recurrently contaminates soils worldwide, mainly by incorporating sewage sludge into cultivated areas, using wastewater in irrigation, and leaching contaminated soils. However, there are few studies on the ecotoxicological effects of this paraben on edaphic organisms.
Lorena Maihury Santos Tsubouchi, Edson Araújo de Almeida, Diane Scapin, Anna Karolina Gomes Oliveira, Cassiano Aparecido de Souza, Diego Espirito Santo, Carmem Lúcia Henrich, Ana Elisa Maehashi, Gideã Taques Tractz, Craig Allan Downs, Osvaldo Valarini Junior, Regiane da Silva Gonzalez, Elisângela Düsman, Ana Paula Peron   +13 more
wiley   +1 more source