Results 161 to 170 of about 1,560,354 (293)

Pharmacokinetics and pharmacodynamics of intranasal insulin in a rat brain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Understanding of the insulin‐mediated effects on signalling and metabolism is important not only for fundamental knowledge of insulin's action in the brain but also for elucidating the mechanism of therapeutic potential in neurodegenerative disorders with underlying brain metabolic dysfunction.
Jelena Osmanovic Barilar, Leonarda Vlahov, Ana Babic Perhoc, Jan Homolak, Davor Virag, Eugenio Barone, Melita Salkovic‐Petrisic, Ana Knezović   +7 more
wiley   +1 more source

Ultrasound Communications Reveal Social Aversion in Rats With Contact Motivation Deficits but not Anhedonia. [PDF]

Alpha Psychiatry
Rebik AA, Broshevitskaya ND, Riga VD, Aleksandrov PL, Zaichenko MI, Midzyanovskaya IS.   +5 more
europepmc   +1 more source

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats. [PDF]

Sci Rep
Raghunath I, Koland M, Saoji SD, Bukke SPN, Deshpande NS, Augustin V, Rarokar N, Thalluri C.   +7 more
europepmc   +1 more source

Dopamine D3 receptor blockade accelerates the extinction of opioid withdrawal‐induced drug‐seeking behaviours and alters microglia in dopaminoceptive nuclei

British Journal of Pharmacology, EarlyView.
Background and Purpose Among all drugs of abuse, opioids cause most of the deaths and treatment seeking. Despite abundant research in multifaceted therapeutic strategies, a high rate of relapse still characterises this condition. Dopamine D3 receptor antagonists combined with cue‐exposure therapies have been proposed to ameliorate the abused drugs ...
Aurelio Franco‐García, Victoria Gómez‐Murcia, M. Victoria Milanés, Cristina Núñez   +3 more
wiley   +1 more source

<i>Etlingera Elatior</i> Inflorescence Extract Mitigates Acute Gastric Ulcers by Suppressing the Expression of Inducible Nitric Oxide Synthase in Ethanol-Induced Wistar Rats. [PDF]

J Exp Pharmacol
Prayoga DK, Aulifa DL, Budiman A, Levita J, Jiranusornkul S.   +4 more
europepmc   +1 more source

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira, José Eduardo da Silva‐Santos   +1 more
wiley   +1 more source

Sleep phenotyping in a rat model of susceptibility to substance use disorders. [PDF]

PLoS One
Ficiarà E, Faniyan OO, Simayi R, Del Gallo F, Roberto M, Ciccocioppo R, Bellesi M, de Vivo L.   +7 more
europepmc   +1 more source

Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib

British Journal of Pharmacology, EarlyView.
Background and Purpose Hidden cardiotoxicity is defined as drug‐induced cardiotoxicity that becomes obvious only in the presence of comorbidities. However, the molecular mechanisms of hidden cardiotoxicity are not always known. Therefore, unbiased multi‐omics approaches could assist in revealing regulatory pathways.
Bennet Y. Weber, Gábor B. Brenner, Barnabás Váradi, Bence Ágg, Csenger Kovácsházi, Olivér M. Balogh, Donagh Egan, Kieran Wynne, David Matallanas, Rainer Schulz, Péter Ferdinandy, Zoltán Giricz, Anikó Görbe   +12 more
wiley   +1 more source

REPRODUCTIVE PERFORMANCE OF WISTAR RATS

Archives of Veterinary Science, 2001
P. R. Dalsenter, M. Ohi
openaire   +2 more sources