Results 191 to 200 of about 1,560,354 (293)

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

Journal of Periodontal Research, EarlyView.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang, Kai‐Fang Hu, Meng‐Xuan Lin, Ching‐Jiunn Tseng, Bin‐Nan Wu, Zen‐Kong Dai, Jong‐Hau Hsu, Jwu‐Lai Yeh   +7 more
wiley   +1 more source

Experimental Models of Type 2 Diabetes Mellitus Induced by Combining Hyperlipidemic Diet (HFD) and Streptozotocin Administration in Rats: An Integrative Review. [PDF]

Biomedicines
Brito AKDS, Mendes AVDS, Timah Acha B, Santos Oliveira ASDS, Lopes Macedo J, Suzuki Cruzio A, Prianti MDG, Abreu RR, Lucarini M, Durazzo A, do Carmo de Carvalho E Martins M, Arcanjo DDR.   +11 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

The Impact of Vatinoxan on the Concentrations of Medetomidine, Midazolam, and Fentanyl in Central Nervous System After Subcutaneous Co‐Administration in Rats

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Our aim was to investigate whether vatinoxan, a peripherally acting alpha2‐adrenoceptor antagonist, would affect the concentrations of medetomidine, midazolam, and fentanyl in the central nervous system after subcutaneous co‐administration. Twelve healthy male Wistar rats, aged between 13 and 15 weeks, were used in this study.
Juhana Honkavaara, Emily Lindh, Anna Meller, Karoliina Alm, Marja R. Raekallio, Pernilla Syrjä   +5 more
wiley   +1 more source

Persistent Renal Oxidative Stress Despite Mannitol Nephroprotection: The Impact of Social-Single Prolonged Stress in Male and Female Rats Exposed to Cisplatin. [PDF]

Cell Biochem Funct
Jung JTK, Klann IP, Fulco BCW, Zborowski VA, Zeni G, Nogueira CW.   +5 more
europepmc   +1 more source

Electroanalysis and electrophysiological recording of bio‐doped conducting polymer‐modified neural electrodes

Annals of the New York Academy of Sciences, EarlyView.
Neural electrodes were modified with poly(3,4‐ethylenedioxythiophene) (PEDOT) doped with chondroitin sulfate or dextran sulfate. Electrochemical and acute electrophysiological recordings were undertaken. The effective electrode area had the strongest correlation with electrophysiological response.
Alexander R. Harris, Ben J. Allitt, Antonio G. Paolini   +2 more
wiley   +1 more source

Reproductive and developmental safety assessment of Ashwagandha (<i>Withania somnifera</i>) root extract in Wistar rats. [PDF]

Front Pharmacol
Kalaiselvan K, Sweatha V, Gayathri V, Kalaivani P, Siva R, Tamrakar S.   +5 more
europepmc   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source