Results 221 to 230 of about 154,604 (268)

Acetaminophen nephrotoxicity in male Wistar rats

Archives of Toxicology, 1992
Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
L, Trumper, G, Girardi, M M, Elías
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Induced palatal candidosis in the Wistar rat

Archives of Oral Biology, 1981
Palatal candidosis was induced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. After 1 week, the palatal epithelium showed acute inflammatory cell infiltration and surface colonization by blastospores. Two weeks after inoculation, the inflammation had increased, micro-abscesses were observed and fungal hyphae penetrated ...
B S, Shakir, M V, Martin, C J, Smith
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Polymorphism in Diazepam Metabolism in Wistar Rats

Journal of Pharmaceutical Sciences, 2004
We observed variations in the metabolism of diazepam in Wistar rats. We studied these variations carefully, and found that the variations are dimorphic and about 17% of male rats of Wistar strain we examined showed two times higher diazepam metabolic activities in their liver microsomes than the rest of animals at the substrate concentrations less than
Konomu, Saito, Hyung-Sub, Kim, Noriaki, Sakai, Mayumi, Ishizuka, Akio, Kazusaka, Shoichi, Fujita   +5 more
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Developmental Toxicity of Homobrassinolide in Wistar Rats

International Journal of Toxicology, 2010
Brassinosteroids (BRs) are close analogues of animal cholesterol. Brassinosteroids have shown their great value as yield promoters of a variety of plants. In view of its steroidal moiety and recent use in agriculture in many countries, the teratogenic potential of homobrassinolide (HBR) was evaluated in Wistar rats. Homobrassinolide was administered by
Yogeshkumar V, Murkunde, P Balakrishna, Murthy   +1 more
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Hematological Characteristics of the BB Wistar Rat

Veterinary Clinical Pathology, 1983
SummaryComplete blood counts, differential white blood cell and platelet counts were performed on male and female BB Wistar diabetic rats (BBWd), their nondiabetic siblings (BBWnd) and outbred Wistar rats of the line from which the BB Wistar rats were derived.
J R, Wright, A J, Yates, N T, Shah, J C, Neff, D W, Covey, P, Thibert   +5 more
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Subchronic Toxicity of Pentostatin in Wistar Rats

Toxicologic Pathology, 1994
Pentostatin, an adenosine deaminase inhibitor, has been approved for the treatment of refractory hairy cell leukemia. In a preclinical toxicity study, Wistar rats were administered 0, 1, 10. 25, and 50 mg/kg (0, 6, 60, 150, and 300 mg/m 2 , respectively) pentostatin intravenously once a week ...
C L, Courtney, K L, Hawkins, C E, Rothwell   +2 more
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A revaluation of the haemoglobin electrophoretogram of the wistar rat

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1971
Abstract 1. 1. Haemoglobins of Wistar rats have been examined by starch and polyacrylamide gel electrophoresis 2. 2. Two haemoglobins are produced during yolk sac erythropoiesis, and two additional haemoglobins appear during liver erythropoiesis. 3. 3. All four haemoglobins persist in the adult. 4. 4.
A R, Shaw, N, Maclean
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Resistance to mineralocorticoids in Wistar-Furth rats

American Journal of Physiology-Heart and Circulatory Physiology, 1997
Wistar-Furth rats (WF) do not develop hypertension when treated with salt and mineralocorticoids and therefore may be useful for investigating the mechanisms of mineralocorticoid action and hypertension. In the present studies, we determined vascular and renal responses of WF to mineralocorticoids. Control Wistar rats (W) developed deoxycorticosterone
M E, Ullian, M M, Islam, C J, Robinson, W R, Fitzgibbon, E T, Tobin, R V, Paul   +5 more
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Anticholinesterasic Activity of Endosulfan in Wistar Rats

Bulletin of Environmental Contamination and Toxicology, 2011
The in vivo and in vitro effects of the pesticide endosulfan on the cholinesterase (ChE) activity were investigated in rats. ChE activity decreased in dams and in male pups within 65 days corresponding to 35% and 32% of inhibition respectively in the higher endosulfan dose (1.5 mg/kg).
Helena Cristina, Silva de Assis, Lilian, Nicaretta, Maria Consuelo Andrade, Marques, Sandra, Crestani, Kelly Cristina, Soares, Delia, Olmedo, Paulo Roberto, Dalsenter   +6 more
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Toxicology Reference Data for the Wistar Rat

1982
Sixty-six observations on Wistar rats, including body and organ weights, biochemistry, hematology, and urinalysis have been compiled over a period of 16 years. A statistical analysis of these observations involved 3,400 Wistar rats that served as controls in toxicity studies.
P J, Lewi, R P, Marsboom
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