Results 81 to 90 of about 1,786,922 (333)

Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD [PDF]

, 2016
Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently ...
Bardo, M. T., Dwoskin, L. P., Kantak, K. M., Somkuwar, S. S.   +3 more
core   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Evaluation of the cognitive, physiological, and biomarker effects of heavy metal exposure in Wistar rats [PDF]

Veterinary World
Background and Aim: Individuals exposed to heavy metals are known to experience physiological and biochemical changes, which raise questions regarding possible health effects.
Senna Mukhi, Poornima Ajay Manjrekar, Rukmini Mysore Srikantiah, Sindhu Harish, Himani Kotian, Y. Lakshmisha Rao, Anita Sherly   +6 more
doaj   +1 more source

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats

Frontiers in Molecular Neuroscience, 2016
Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino ...
C. Ari, Z. Kovács, G. Juhász, Cem Murdun, Craig R. Goldhagen, A. Koutnik, Angela Poff, S. Kesl, D. D'Agostino   +8 more
semanticscholar   +1 more source

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

Advanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang, Chenle Dong, Lefeng Su, Zhiqiang Liu, Lingyi Hu, Qishu Jin, Hao Chen, Chunlong Zhang, Yihao Wu, Jiang Chang, Zhaowenbin Zhang, Jiandong Yuan   +11 more
wiley   +1 more source

Subchronic Toxicity of Green Algae (Spyrogyra SP.) Ethanolic Extract on Hematologic Parameters [PDF]

, 2016
Green Algae, an organism with active substance such as phytomelatonin, has potential to be developed as Indonesian traditional medicine. As the long term addition of Green Algae ethanol extract (Ekstrak etanol ganggang hijau, EEGH) influences the ...
Devi, A. (Anggita), Putri, Z. A. (Zahra), Salamah, N. (Nina), Sejati, A. W. (Anita), Susanti, H. (Hari), Widyaningsih, W. (Wahyu)   +5 more
core  

Effect of an extract of Centella asiatica on the biodistribution of sodium pertechnetate (Na^99mTcO₄) and on the fixation of radioactivity on blood constituents [PDF]

, 2008
This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical Na99mTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract
Adenilson de Souza da Fonseca, Benarroz M. O., Bernardo-Filho M., Capriles P. V., Claudia Leite Diniz, Danielle Santos de Almeida, Fernanda Santos do Carmo, Fonseca A. S., Frydman J. N. G., Goel H. C., Inamdar P. K., Jayashree G., Mario Bernardo Filho, Moreno S.R., Owunwanne A., Padma P. R., Rebello B. M., Saha G. B., Sebastião David Santos-Filho, Sharma J., Shobi V., Simões C. M. O., Sotiris Missailidis   +22 more
core   +4 more sources

Fenugreek seed extract attenuates cisplatin‐induced testicular damage in Wistar rats

Andrologia, 2016
Cisplatin (CIS) provides oxidative stress and inflammations in testicular tissues. Fenugreek seed extract (FSE) is a widely used herbal medicine with potent antioxidant and anti‐inflammation properties.
A. Hamza, H. Elwy, A. M. Badawi
semanticscholar   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source