Results 1 to 10 of about 1,697,740 (179)

Development of an Immunochromatography Assay to Detect Marburg Virus and Ravn Virus [PDF]

Viruses, 2023
The recent outbreaks of Marburg virus disease (MVD) in Guinea, Ghana, Equatorial Guinea, and Tanzania, none of which had reported previous outbreaks, imply increasing risks of spillover of the causative viruses, Marburg virus (MARV) and Ravn virus (RAVV),
Katendi Changula, Masahiro Kajihara, Shino Muramatsu, Koji Hiraoka, Toru Yamaguchi, Yoko Yago, Daisuke Kato, Hiroko Miyamoto, Akina Mori-Kajihara, Asako Shigeno, Reiko Yoshida, Corey W. Henderson, Andrea Marzi, Ayato Takada   +13 more
doaj   +7 more sources

Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Rousettus aegypticus) [PDF]

Journal of Virology
Marburg virus (MARV) and Ravn virus (RAVV), the only two known members of the species Orthomarburgvirus marburgense (family Filoviridae), are causative agents of Marburg virus disease, a severe viral disease that typically emerges in sub-Saharan Africa ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +6 more sources

Genomic Evolution and Phylodynamics of the Species Orthomarburgvirus marburgense (Marburg and Ravn Viruses) to Understand Viral Adaptation and Marburg Virus Disease’s Transmission Dynamics [PDF]

Pathogens
In this review, we investigated the genetic diversity and evolutionary dynamics of the Orthomarburgvirus marburgense species that includes both Marburg virus (MARV) and Ravn virus (RAVV).
Claude Mambo Muvunyi, Nouh Saad Mohamed, Emmanuel Edwar Siddig, Ayman Ahmed   +3 more
doaj   +7 more sources

siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease. [PDF]

J Clin Invest, 2017
Ebolaviruses and marburgviruses belong to the family Filoviridae and cause high lethality in infected patients. There are currently no licensed filovirus vaccines or antiviral therapies. The development of broad-spectrum therapies against members of the Marburgvirus genus, including Marburg virus (MARV) and Ravn virus (RAVV), is difficult because of ...
Thi EP, Mire CE, Lee AC, Geisbert JB, Ursic-Bedoya R, Agans KN, Robbins M, Deer DJ, Cross RW, Kondratowicz AS, Fenton KA, MacLachlan I, Geisbert TW.   +12 more
europepmc   +6 more sources

Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody. [PDF]

Sci Transl Med, 2017
A single mAb is an effective therapy in nonhuman primates infected with Marburg or Ravn virus.
Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, Deer DJ, Steinkellner H, Bohorov O, Bohorova N, Goodman C, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Crowe JE, Zeitlin L, Geisbert TW.   +18 more
europepmc   +6 more sources

Marburg and Ravn Virus Infections Do Not Cause Observable Disease in Ferrets. [PDF]

J Infect Dis, 2018
Ferrets are used for studying infections with wild-type Ebola virus isolates. Here, we investigated whether these animals are also susceptible to wild-type isolates of Marburg virus (MARV). Ferrets were challenged intramuscularly or intranasally with MARV strain Angola and monitored for 3 weeks. Unexpectedly, the animals neither showed observable signs
Wong G, Zhang Z, He S, de La Vega MA, Tierney K, Soule G, Tran K, Fernando L, Qiu X.   +8 more
europepmc   +6 more sources

Distinct Biological Phenotypes of Marburg and Ravn Virus Infection in Macaques. [PDF]

J Infect Dis, 2018
Filoviruses are among the most pathogenic infectious agents known to human, with high destructive potential, as evidenced by the recent Ebola virus epidemic in West Africa. As members of the filovirus family, marburgviruses have caused similar devastating outbreaks, albeit with lower case numbers. In this study we compare the pathogenesis of Ravn virus
Nicholas VV, Rosenke R, Feldmann F, Long D, Thomas T, Scott DP, Feldmann H, Marzi A.   +7 more
europepmc   +6 more sources

Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses [PDF]

Nature Communications
The first-ever recent Marburg virus (MARV) outbreak in Tanzania and recent emergences in Rwanda, Ghana and Equatorial Guinea underscore the importance of therapeutic or vaccine development against the virus, for which none are approved.
Michelle Meyer, Bronwyn M. Gunn, Colette Pietzsch, Chandru Subramani, Kritika Kedarinath, Paula P. Villarreal, Matthew A. Hyde, Erica Ollmann Saphire, James E. Crowe, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +12 more
doaj   +8 more sources

Maternal Filovirus Infection and Death from Marburg and Ravn Viruses: Highly Lethal to Pregnant Women and Their Fetuses Similar to Ebola Virus [PDF]

Emerging Challenges in Filovirus Infections, 2020
Ebola virus and the marburgviruses are distinct filoviruses that share common clinical presentations and clinical management protocols. However, the marburgviruses are not as well known as is their close relative, Ebola virus, and are a much less ...
David A. Schwartz
core   +6 more sources

Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential [PDF]

npj Viruses
Marburg virus (MARV) and Ravn virus (RAVV) are highly pathogenic filoviruses that cause Marburg virus disease (MVD), for which no approved treatment currently exists.
Takeshi Saito, Hiroko Miyamoto, Manabu Igarashi, Asuka Nanbo, Risa Hayashi, Ruchi Paroha, Gavriella Siman-Tov, Kirsten Littlefield, Akina Mori-Kajihara, Christine Click, Wakako Furuyama, Slobodan Paessler, Junki Maruyama, Ayato Takada   +13 more
doaj   +5 more sources