Results 21 to 30 of about 1,697,740 (179)

Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification [PDF]

Nature Communications
Filoviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Yi-Zong Lee, Yi-Nan Zhang, Maddy L. Newby, Garrett Ward, Keegan Braz Gomes, Sarah Auclair, Connor DesRoberts, Joel D. Allen, Andrew B. Ward, Robyn L. Stanfield, Linling He, Max Crispin, Ian A. Wilson, Jiang Zhu   +13 more
doaj   +2 more sources

Non-Ebola Filoviruses: Potential Threats to Global Health Security [PDF]

Viruses
Filoviruses are negative-sense single-stranded RNA viruses often associated with severe and highly lethal hemorrhagic fever in humans and nonhuman primates, with case fatality rates as high as 90%.
Yannick Munyeku-Bazitama, Francois Edidi-Atani, Ayato Takada   +2 more
doaj   +2 more sources

Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice

Journal of Infectious Diseases
Marburgviruses cause severe hemorrhagic disease in humans, yet characterization of rodent models for pathogenesis and medical countermeasure development remains limited.
Katherine A Davies, Stephen R. Welch, JoAnn D Coleman-McCray, Teresa E. Sorvillo, Virginia Aida-Ficken, Shilpi Jain, César G. Albariño, Biao He, Christina F Spiropoulou, Jessica R. Spengler   +9 more
openalex   +2 more sources

Serological Detection of Ebola Virus Exposures in Native Non-human Primates of Southern Nigeria

Journal of Epidemiology and Global Health, 2018
Ebola viruses (family: Filoviridae) are the cause of Ebola virus disease (EVD), a highly fatal illness characterised by haemorrhagic fever syndrome in both humans and non-human primates (NHPs).
B.N. Ogunro, B.O. Olugasa, E.J. Verschoor, A.O. Olarinmoye, I. Theyse, H. Niphuis   +5 more
doaj   +2 more sources

Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles.

PLoS ONE, 2015
Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates.
Kelly L Warfield, John M Dye, Jay B Wells, Robert C Unfer, Frederick W Holtsberg, Sergey Shulenin, Hong Vu, Dana L Swenson, Sina Bavari, M Javad Aman   +9 more
doaj   +2 more sources

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health. [PDF]

Microb Biotechnol
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Brüssow H.
europepmc   +2 more sources

The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya [PDF]

, 2009
Background Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between ...
Charles Sande, D. James Nokes, Graham F. Medley, Gregory Fegan, Lisa F. P. Ng, Patricia A. Cane, Paul D. Scott, Rachel Ochola   +7 more
core   +10 more sources

Marburg virus disease Mayhem: A new threat emerges in Rwanda [PDF]

New Microbes and New Infections
Pawan Kumar, Jezina Jayan, Ashok Kumar Balaraman, Sakshi Pandey, Manvinder Brar, Rachana Mehta, Sanjit Sah   +6 more
doaj   +2 more sources

Histopathologic and Immunohistochemical Evaluation of Induced Lesions, Tissue Tropism and Host Responses following Experimental Infection of Egyptian Rousette Bats (Rousettus aegyptiacus) with the Zoonotic Paramyxovirus, Sosuga Virus

Viruses, 2022
Ecological and experimental infection studies have identified Egyptian rousette bats (ERBs; Rousettus aegyptiacus: family Pteropodidae) as a reservoir host for the zoonotic rubula-like paramyxovirus Sosuga virus (SOSV). A serial sacrifice study of colony-
Shannon G. M. Kirejczyk, Brian R. Amman, Amy J. Schuh, Tara K. Sealy, César G. Albariño, Jian Zhang, Corrie C. Brown, Jonathan S. Towner   +7 more
doaj   +1 more source

Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study

Viruses, 2021
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi, Takatsugu Hirokawa, Yoshihiro Takadate, Ayato Takada   +3 more
doaj   +1 more source