Results 91 to 100 of about 1,743,362 (341)
COSMIC-RAYS AND GAMMA RAY BURSTS
EAS Publications Series, 2013 Cosmic-rays are subatomic particles of energies ranging between a few eV to hundreds of TeV. These particles register a power-law spectrum, and it seems that most of them originate from astrophysical galactic and extragalactic sources. The shock acceleration in superalfvenic astrophysical plasmas, is believed to be the main mechanism responsible for ...
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The Astrophysical JournalStudying the afterglow of gamma-ray bursts (GRBs) is essential for refining theoretical models, uncovering their underlying physical processes, and exploring potential new physics. Multiwavelength investigations have emerged as a fundamental approach for
Heng-Jiao Liu +20 more
doaj +1 more source
Looking Back: Unneeded X-rays [PDF]
, 2000 From the discovery of x-rays in 1896 to the present, Dr.
Mazur, Allan
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Croatian Journal of Fisheries, 2018 The taxonomic research of eight populations of Sabanejewia balcanica from the water catchment area of the river Sava included the analysis of the meristic characteristics and pigmentation of their bodies.
Bajrić Alen +4 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Limnological ReviewAmazonian fishes, as an adaptive form to the annual flood cycle, develop physiological strategies to adjust to variations in their habitats. The results of this study help to understand how freshwater stingrays adapt to changes in river levels and allow ...
Adriano Teixeira de Oliveira +9 more
doaj +1 more source
Spectrum of the Isotropic Diffuse Gamma-Ray Emission Derived from First-Year Fermi Large Area Telescope Data [PDF]
, 2010 A. A. Abdo +99 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source