Results 81 to 90 of about 411,008 (315)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Regulating the Vascular Cambium: Do Not Forget the Vascular Ray Initials and Their Derivatives
PlantsThe secondary lateral meristem—the vascular cambium (hereafter cambium)—is the largest meristem of the plant kingdom. It is almost always composed of two types of stem cells: (1) the axial (fusiform) initials, the most common and better known and studied,
Simcha Lev-Yadun
doaj +1 more source
Journal of Forest Science, 2008 The aim of this study was to compare the structure of beech juvenile and mature wood in relation to wood density. The comparative analysis between juvenile and mature wood examined the diameter of vessels, the width and height of pith rays, and the ...
V. Gryc +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
X-Ray Flashes and X-Ray Rich Gamma Ray Bursts
, 2006 6 pages, 3 figures (2 in color), to appear in the proceedings of the October 2000 Rome Workshop on ``Gamma-Ray Bursts in the Afterglow Era''
Heise, John +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Comparing and evaluating the efficacy of the TOR18FG Leeds test X-ray phantom for T-rays [PDF]
, 2013 The commercially available X-ray fluoroscopy quality assurance phantom, the Leeds test object TOR18FG, was found to be suitable to assess T-ray image quality in the range (0.1-0.4) THz at a depth of 0.5 cm.
Roger Lewis (19588450) +3 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source