Results 81 to 90 of about 271,565 (266)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Drivers of Mesozoic Neoselachian Success and Resilience

Biology
The modern diversity of sharks, skates, and rays (Neoselachii) is the result of various diversification and extinction events during the Mesozoic (252–66 Ma).
Manuel Andreas Staggl, Carlos De Gracia, Faviel A. López-Romero, Sebastian Stumpf, Eduardo Villalobos-Segura, Michael J. Benton, Jürgen Kriwet   +6 more
doaj   +1 more source

Glenohumeral Passive Range of Motion and the Correlation to Shoulder Injuries in Professional Baseball Pitchers

Orthopaedic Journal of Sports Medicine, 2013
Objectives: Glenohumeral internal rotation deficit (GIRD) indicates a 20 degree or greater loss of IR on the throwing shoulder compared to the non-throwing shoulder.
Kevin E. Wilk PT, DPT, Leonard Macrina, Glenn S. Fleisig PhD, Kyle Aune MPH, Ron Porterfield, Paul Harker, James R. Andrews MD   +6 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Glenohumeral Passive Range Of Motion And The Correlation To Elbow Injuries In Professional Baseball Pitchers

Orthopaedic Journal of Sports Medicine, 2013
Objectives: The purpose of this study was to determine whether GIRD and/or bilateral difference in total rotational motion (TRM) of the glenohumeral joint (external rotation + internal rotation) correlated with elbow injuries in professional baseball ...
Kevin E. Wilk PT, DPT, Leonard Macrina, Glenn S. Fleisig PhD, Kyle Aune MPH, Ron Porterfield, Paul Harker, James R. Andrews MD   +6 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Formação de professores: uma alternativa de dinâmica curricular

Educação (Santa Maria. Online), 2011
No texto relata-se, em forma de síntese, uma alternativa de dinâmica curricular em andamento, elaborada entre os anos de 1999 e 2002, para a formação de professores.
Oswaldo Alonso Rays
doaj  

Experimental investigation of RC beams strengthened with externally bonded BFRP composites

Open Engineering
The goal of this article is to examine the behavior of reinforced concrete (RC) rays that strengthen superficially the basalt fiber-reinforced polymer (BFRP) fabrics.
Al-Asadi Ali K., Alrebeh Salih K., Hadi Waleed Kh.   +2 more
doaj   +1 more source